The effect of spatial position of calorie information on choice, consumption and attention. ESRI WP615, February 2019

We report a “lab-in-the-field” experiment designed to test the impact of posting calories on menus. The study adds substantially to previous work by testing different spatial arrangements of price and calorie information. Choices were real, not hypothetical, and participants were unaware that their lunch choice was part of a study, even though their eye-movements were being tracked. Participants exposed to calorie information ordered 93 fewer calories (11%) relative to a control group. The impact was strongest when calorie information was presented on menus just to the right of the price, in an equivalent font. The difference in number of calories consumed was greater still. These effects were mediated by knowledge of the amount of calories in the meal, implying that calorie posting led to more informed decision making. There was no impact on enjoyment of the meal. Eye-tracking data suggested that this arrangement altered the decision process such that greater decision weight was given to calorie content

Underestimation of money growth and pensions: Experimental investigations. ESRI WP611, February 2019

People underestimate long-term growth in savings because they linearise exponential growth – a phenomenon known as exponential growth bias (EGB). This bias has implications for multiple financial decisions, particularly those relating to pensions. We hypothesised that underestimation might be even more severe for regular savings relative to lump sums, because savers need also to estimate accumulation. The additional cognitive load could strengthen EGB, or individuals might underestimate accumulation in addition to EGB. Four experiments investigated: (1) whether underestimation of money growth is greater for long streams of regular savings than for lump sums; (2) whether underestimation occurs when questions are framed intuitively as the cost of delaying starting a pension; and (3) whether practice with a calculator designed to illustrate the cost of delay attenuates underestimation. Individuals were more likely to underestimate money growth from regular savings than from lump sums, because they failed to accumulate contributions in addition to displaying EGB. Underestimation was substantial and persistent. Practice with a calculator partially attenuated underestimation, primarily among individuals with higher educational attainment and without a pension. Overall, these findings imply that across multiple judgements, decisions and frames, individuals substantially underestimate money growth, reducing the attractiveness of saving

The framing of options for retirement: Experimental tests for policy. ESRI WP604, December 2018

We hypothesise and confirm a substantial framing effect in relation to whether people opt for an annuity on retirement. Two laboratory experiments were conducted in collaboration with a national pensions regulator. Individuals demanded a higher annuity rate when pensions were initially conceived of as an accumulated lump sum – a “nest egg” or “pension pot” – than when they were initially conceived of as retirement income. The effect was recorded using both a matching and a choice procedure. Effect sizes implied more than a doubling of demand for annuities at market rates. While mindful of the need for caution in generalising from hypothetical laboratory studies, the findings have potentially strong policy implications. The framing of pension products in marketing materials and disclosures may have substantial effects on financial risks borne in later life

Interventions to increase physical activity in disadvantaged communities: A review of behavioural mechanisms. ESRI Working Paper No. 646 December 2019

Physical inactivity is now a significant driver of health and social inequalities among socioeconomically disadvantaged communities and poses a major challenge to policymakers, worldwide. Although a vast amount of research has focused on designing and evaluating interventions to increase physical activity, there remains little consensus on which interventions are likely to work. In this narrative review, we build on previous reviews by not only examining what interventions tend to work but by trying to understand why certain interventions tend to work, while others do not, through the lens of behavioural science. We present a behavioural framework through which the existing body of physical activity research could be viewed, in order to identify potentially effective mechanisms that would be likely to work in their intended domain. Our analysis finds that while there is evidence that the physical and educational environment matter for increasing levels of physical activity, interventions are more likely to be successful where they involve a social component. We conclude that a behaviourally informed physical activity intervention would thus employ a set of focused educational and socially-mediated behavioural mechanisms, within an appropriate physical environment

Development of a Hydrogeological Model of the Borrowdale Volcanics at Sellafield

International audienceThis work has arisen out of recent developments within the radioactive waste research programme managed by Her Majesty's Inspectorate of Pollution, UK (HMIP)*, to develop an integrated flow and transport model for the potential deep radioactive waste repository at Sellafield. One of the largest sources of uncertainty in model predictions, is the characterisation of the hydrogeological properties of the underlying strata, in particular, of the Borrowdale Volcanic Group (BVG) within which the repository is to be located. Analysis of the available borehole data (that released by the proponent company, Nirex, by December 1995) for the BVG formation has indicated a dual regime consisting of flow within faults and flow within the matrix (or an equivalent porous medium containing micro-fractures). Significant relationships between permeability, depth and the presence and orientation of faults have been identified; they account for a variation of up to 6 orders of magnitude in mean permeability measurements. This can be explained in part by the effect of the orientation of the current maximum principal stress directions within the BVG: however, it is likely that permeability is also dependent on the existence of fracture families, which cannot be effectively identified from the data currently available. These analyses have enabled considerable insight to be gained into the dominant features of flow within the BVG. The conceptual hydrogeological model derived here will have a significant effect on the outcome and reliability of future radionuclide transport predictions in the Sellafield area

Alien Registration- Lunn, Howard A. (Mars Hill, Aroostook County)

https://digitalmaine.com/alien_docs/33981/thumbnail.jp

Motivating social distancing during the Covid-19 pandemic: An online experiment. ESRI Working Paper No. 658 April 2020

Social distancing during the COVID-19 pandemic will save lives. We tested communication strategies to promote social distancing via an online experiment (N = 500) commissioned by Ireland’s Department of Health. A control group saw a current informational poster. Two treatment groups saw similar posters with messages that highlighted: (i) the risk of transmission to identifiable persons vulnerable to COVID-19; (ii) the exponential nature of transmission. We then measured judgements of behaviours previously identified by focus groups as “marginal” (meaning that people were not sure whether they were advisable, such meeting others outdoors, or visiting parents). We recorded intention to undertake behaviours and stated acceptability of behaviours. Our hypotheses, that both treatments would increase participants’ caution about marginal behaviours, were preregistered (i.e. lodged with an international organisation for open science before data collection). Results confirmed the hypotheses. The findings suggest that the thought of infecting vulnerable people or large numbers of people can motivate social distancing. This has implications for communications strategies. The stud

Neuropsychiatric systemic lupus erythematosus: a diagnostic challenge

A 58-year-old woman presented to neuropsychiatric services with increased frequency of confusional episodes and intermittent psychotic symptoms. She had a 19-year history of atypical epileptic seizures and cognitive decline. Detailed review of history and clinical investigations revealed that she had accumulated sufficient features to meet diagnostic criteria for systemic lupus erythematosus (SLE). She had previously had lymphopenia and a malar rash; she had positive antinuclear, anti-Ro (anti-Sjögren's-syndrome-related antigen A) and anti-SM (anti-Smith Antibody) antibodies, and elevated erythrocyte sedimentation rate. The seizures, cognitive impairment and psychosis were attributable to neuropsychiatric SLE. Treatment with immune-modulating therapy, cyclophosphamide, resulted in significant improvement in subjective and objective clinical presentation. Neuropsychiatric SLE should be considered a potential differential diagnosis for patients presenting with seizures, psychotic symptoms or cognitive decline. A detailed clinical evaluation with review of the medical history and appropriate laboratory analyses allows this diagnosis to be made, and appropriate treatment to be initiated

Concise Review: Stem Cell Therapies for Amyotrophic Lateral Sclerosis: Recent Advances and Prospects for the Future

Amyotrophic lateral sclerosis (ALS) is a lethal disease involving the loss of motor neurons. Although the mechanisms responsible for motor neuron degeneration in ALS remain elusive, the development of stem cell‐based therapies for the treatment of ALS has gained widespread support. Here, we review the types of stem cells being considered for therapeutic applications in ALS, and emphasize recent preclinical advances that provide supportive rationale for clinical translation. We also discuss early trials from around the world translating cellular therapies to ALS patients, and offer important considerations for future clinical trial design. Although clinical translation is still in its infancy, and additional insight into the mechanisms underlying therapeutic efficacy and the establishment of long‐term safety are required, these studies represent an important first step toward the development of effective cellular therapies for the treatment of ALS. S tem C ells 2014;32:1099–1109Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106861/1/stem1628.pd

Impact of altered cell wall composition on saccharification efficiency in stem tissue of Arabidopsis RABA GTPase-deficient knockout mutants

Use of biomass for second-generation biofuel production is severely hindered by the inherent recalcitrance of the plant cell wall to digestion. Trafficking is crucial for compartmentalisation within the cell. This process is partly regulated by small Rab GTPase proteins. In particular, control of trafficking to the cell wall is regulated through the RABA clade. Manipulation of this regulatory system offers tantalising opportunities for manipulation of cell wall composition and hence recalcitrance. Trafficking-defective rabA mutants have already been shown to impact cell wall composition. To study the impacts of these mutants on cell wall digestion, we developed a saccharification process for Arabidopsis based on the hot water method. We then showed that following pre-treatment, stems from the T-DNA knockouts of the three RABA4 genes expressed in Arabidopsis stem show an increased sugar release on saccharification. These rabA4 mutants have been shown to impact the “hemicellulose-rich” fraction during cell wall fractionation. Furthermore, we go on to show that these mutant lines also show increased sugar release when subjected to saccharification without pre-treatment. Finally, we used X-ray diffraction to show that rabA4 mutants had no impact on cellulose crystallinity, thus supporting the hypothesis that the increases in saccharification were not due to alterations of the cellulose microfibrils but were a direct effect of reduced hemicellulose levels. We also present data to show that the growth characteristics of these plants were unaffected. The data obtained from these lines are most easily explained by the reported alteration in hemicellulose increasing pre-treatment efficiency