La médiation internationale de la théorie à la pratique: la crise ivoirienne de 2002 à 2005

ope

Lightweight rotor design by optimal spar cap offset

Bend-twist coupling behavior is induced in a blade by displacing the suction side spar cap towards the leading edge, and the pressure side one in the opposite direction. Additional couplings are introduced by rotating the spar cap fibers. The structural configuration of the blade is optimized using an automated design environment. The resulting blade shows significant benefits in terms of mass and loads when compared to the baseline uncoupled one. Finally, the lightweight design concept is used to increase the rotor size, resulting in a larger energy yield for the same hub loads

Disinfection of swimming pools with chlorine and derivatives: formation of organochlorinated and organobrominated compounds and exposure of pool personnel and swimmers

n/

Addressing docking pose selection with structure-based deep learning: Recent advances, challenges and opportunities

Molecular docking is a widely used technique in drug discovery to predict the binding mode of a given ligand to its target. However, the identification of the near-native binding pose in docking experiments still represents a challenging task as the scoring functions currently employed by docking programs are parametrized to predict the binding affinity, and, therefore, they often fail to correctly identify the ligand native binding conformation. Selecting the correct binding mode is crucial to obtaining meaningful results and to conveniently optimizing new hit compounds. Deep learning (DL) algorithms have been an area of a growing interest in this sense for their capability to extract the relevant information directly from the protein-ligand structure. Our review aims to present the recent advances regarding the development of DL-based pose selection approaches, discussing limitations and possible future directions. Moreover, a comparison between the performances of some classical scoring functions and DL-based methods concerning their ability to select the correct binding mode is reported. In this regard, two novel DL-based pose selectors developed by us are presented

L'economia politica e l'evoluzione del capitalismo negli ultimi quarant'anni

Convegno in onore di Giorgio Lunghin

L'economia politica e l'evoluzione del capitalismo negli ultimi quarant'anni

Convegno in onore di Giorgio Lunghini