123 research outputs found

    Endothelin-Dependent Vasoconstriction in Human Uterine Artery: Application to Preeclampsia

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    BACKGROUND: Reduced uteroplacental perfusion, the initiating event in preeclampsia, is associated with enhanced endothelin-1 (ET-1) production which feeds the vasoconstriction of uterine artery. Whether the treatments of preeclampsia were effective on ET-1 induced contraction and could reverse placental ischemia is the question addressed in this study. We investigated the effect of antihypertensive drugs used in preeclampsia and of ET receptor antagonists on the contractile response to ET-1 on human uterine arteries. METHODOLOGY/PRINCIPAL FINDINGS: Experiments were performed, ex vivo, on human uterine artery samples obtained after hysterectomy. We studied variations in isometric tension of arterial rings in response to the vasoconstrictor ET-1 and evaluated the effects of various vasodilators and ET-receptor antagonists on this response. Among antihypertensive drugs, only dihydropyridines were effective in blocking and reversing the ET-1 contractile response. Their efficiency, independent of the concentration of ET-1, was only partial. Hydralazine, alpha-methyldopa and labetalol had no effect on ET-1 induced contraction which is mediated by both ET(A) and ET(B) receptors in uterine artery. ET receptors antagonists, BQ-123 and BQ-788, slightly reduced the amplitude of the response to ET-1. Combination of both antagonists was more efficient, but it was not possible to reverse the maximal ET-1-induced contraction with antagonists used alone or in combination. CONCLUSION: Pharmacological drugs currently used in the context of preeclampsia, do not reverse ET-1 induced contraction. Only dihydropyridines, which partially relax uterine artery previously contracted with ET-1, might offer interesting perspectives to improve placental perfusion

    Влияние фосфатных связующих на физико-механические свойства периклазохромитовых огнеупоров

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    У данній статті наведено та порівняно фізико-механічні властивості периклазо-хромітових матеріалів в залежності від різних типів фосфатних зв’язуючих та введення різних домішок. Визначено, що найбільш раціональним є введення триполіфосфату натрію.In given clause are resulted and the physycal-mechanical properties periclase-cgromite of materials are compared depending on different of types phosphate binding and introduction of the various additives. Is determined, that most rational is the introduction treepolyphosphate sodume

    Stability of Halogen-Terminated Diamond (111) Surfaces

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    Quantum Chemical Study of Photoinjection Processes in Dye-Sensitized TiO 2

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    Relativistic calculation of 2p53s, 3p and 3d energy levels and transition wavelengths in Ti XIII, Fe XVII and some other neon-like ions

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    Average energies for the configurations 2p5 3s, 3p and 3d in a number of neon-like ions from Al IV to Xe XLV have been calculated by means of the MCDF computer code of Grant et al. The results have been compared with observations and previous non-relativistic calculations. Fine- structure levels and 3s-3p and ip-3d transition wavelengths have also been calculated with the MCDF code for Ti XIII and Fe XVII, both in the single-configuration approximation and in a multiconfiguration treatment including 2s 2p6 nl. The configuration interaction was found to affect 2p5 3p3S1 most seriously. A separate optimization for the 3p1S0 state was needed, due to the particular radial dependence of this state. The calculated wavelengths show excellent agreement with the observations, and the MCDF calculations are well suited for wavelength predictions in neon-like n = 3 system
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