Optimering av bärlina i bärande lättregelväggar av trä.

Examensarbetet innehåller en studie av bärande träregelväggar. Bärförmågan har optimerats för en given belastning. Väggen belastas med vertikala punktlaster, från takstolarna, i sin överkant

Gas spectroscopy and optical path-length assessment in scattering media using a frequency-modulated continuous-wave diode laser

Simultaneous assessment of the spectroscopic absorption signal of gas enclosed in a scattering medium and the corresponding optical path length of the probing light is demonstrated using a single setup. Sensitive gas absorption measurements are performed by a tunable diode laser using wavelength-modulation spectroscopy, while the path length is evaluated by the frequency-modulated cw technique commonly used in the field of telecommunication. Proof-of-principle measurements are demonstrated with water vapor as the absorbing gas and using polystyrene foam as an inhomogeneously scattering medium. The combination of these techniques opens up new possibilities for straightforward evaluation of gas presence and exchange in scattering media. (C) 2011 Optical Society of Americ

Remote nocturnal bird classification by spectroscopy in extended wavelength ranges

We present optical methods at a wide range of wavelengths for remote classification of birds. The proposed methods include eye-safe fluorescence and depolarization lidar techniques, passive scattering spectroscopy, and infrared (IR) spectroscopy. In this paper we refine our previously presented method of remotely classifying birds with the help of laser-induced beta-keratin fluorescence. Phenomena of excitation quenching are studied in the laboratory and are theoretically discussed in detail. It is shown how the ordered microstructures in bird feathers induce structural "colors" in the IR region with wavelengths of around 3-6 mu m. We show that transmittance in this region depends on the angle of incidence of the transmitted light in a species-specific way and that the transmittance exhibits a close correlation to the spatial periodicity in the arrangement of the feather barbules. We present a method by which the microstructure of feathers can be monitored in a remote fashion by utilization of thermal radiation and the wing beating of the bird. (C) 2011 Optical Society of Americ

TIM23-mediated insertion of transmembrane α-helices into the mitochondrial inner membrane

This comprehensive analysis of the sequence determinants for TIM23-mediated insertion of mitochondrial inner membrane proteins reveals strikingly different requirements for protein insertion into the mitochondrial inner membrane and the endoplasmic reticulum

Translational Database Selection and Multiplexed Sequence Capture for Up Front Filtering of Reliable Breast Cancer Biomarker Candidates

Biomarker identification is of utmost importance for the development of novel diagnostics and therapeutics. Here we make use of a translational database selection strategy, utilizing data from the Human Protein Atlas (HPA) on differentially expressed protein patterns in healthy and breast cancer tissues as a means to filter out potential biomarkers for underlying genetic causatives of the disease. DNA was isolated from ten breast cancer biopsies, and the protein coding and flanking non-coding genomic regions corresponding to the selected proteins were extracted in a multiplexed format from the samples using a single DNA sequence capture array. Deep sequencing revealed an even enrichment of the multiplexed samples and a great variation of genetic alterations in the tumors of the sampled individuals. Benefiting from the upstream filtering method, the final set of biomarker candidates could be completely verified through bidirectional Sanger sequencing, revealing a 40 percent false positive rate despite high read coverage. Of the variants encountered in translated regions, nine novel non-synonymous variations were identified and verified, two of which were present in more than one of the ten tumor samples

A picture of medically assisted reproduction activities during the COVID-19 pandemic in Europe

STUDY QUESTION: How did coronavirus disease 2019 (COVID-19) impact on medically assisted reproduction (MAR) services in Europe during the COVID-19 pandemic (March to May 2020)? SUMMARY ANSWER: MAR services, and hence treatments for infertile couples, were stopped in most European countries for a mean of 7 weeks. WHAT IS KNOWN ALREADY: With the outbreak of COVID-19 in Europe, non-urgent medical care was reduced by local authorities to preserve health resources and maintain social distancing. Furthermore, ESHRE and other societies recommended to postpone ART pregnancies as of 14 March 2020. STUDY DESIGN, SIZE, DURATION: A structured questionnaire was distributed in April among the ESHRE Committee of National Representatives, followed by further information collection through email. PARTICIPANTS/MATERIALS, SETTING, METHODS: The information was collected through the questionnaire and afterwards summarised and aligned with data from the European Centre for Disease Control on the number of COVID-19 cases per country. MAIN RESULTS AND THE ROLE OF CHANCE: By aligning the data for each country with respective epidemiological data, we show a large variation in the time and the phase in the epidemic in the curve when MAR/ART treatments were suspended and restarted. Similarly, the duration of interruption varied. Fertility preservation treatments and patient supportive care for patients remained available during the pandemic. LARGE SCALE DATA: N/A. LIMITATIONS, REASONS FOR CAUTION: Data collection was prone to misinterpretation of the questions and replies, and required further follow-up to check the accuracy. Some representatives reported that they, themselves, were not always aware of the situation throughout the country or reported difficulties with providing single generalised replies, for instance when there were regional differences within their country. WIDER IMPLICATIONS OF THE FINDINGS: The current article provides a basis for further research of the different strategies developed in response to the COVID-19 crisis. Such conclusions will be invaluable for health authorities and healthcare professionals with respect to future similar situations.peer-reviewe