Traduire Claude Simon en danois : Le Jardin des Plantes et Le Tramway

En 1963 paraît la traduction en danois de La Route des Flandres (Vejen i Flandern). Celle de L’Herbe (Græs, 1961) l’avait précédée. Puis suivent Histoire (Historie, 1969), La Bataille de Pharsale (Slaget ved Farsalos, 1971), Triptyque (Triptykon, 1974), Les Géorgiques (Georgica, 1983), L’Acacia (Akacietræet, 1989), et, traduits par nous-même, Le Jardin des Plantes (Jardin des Plantes, 2000) et Le Tramway (Sporvognen, 2006). Nous discuterons ici, après une présentation succincte de quelques id..

Interpreting Sentinel-1 SAR Backscatter Signals of Snowpack Surface Melt/Freeze, Warming, and Ripening, Through Field Measurements and Physically-Based SnowModel

The transition of a cold winter snowpack to one that is ripe and contributing to runoff is crucial to gauge for water resource management, but is highly variable in space and time. Snow surface melt/freeze cycles, associated with diurnal fluctuations in radiative inputs, are hallmarks of this transition. C-band synthetic aperture radar (SAR) reliably detects meltwater in the snowpack. Sentinel-1 (S1) C-band SAR offers consistent acquisition patterns that allow for diurnal investigations of melting snow. We used over 50 snow pit observations from 2020 in Grand Mesa, Colorado, USA, to track temperature and wetness in the snowpack as a function of depth and time during snowpack phases of warming, ripening, and runoff. We also ran the physically-based SnowModel, which provided a spatially and temporally continuous independent indication of snowpack conditions. Snowpack phases were identified and corroborated by comparing field measurements with SnowModel outputs. Knowledge of snowpack warming, ripening, and runoff phases was used to interpret diurnal changes in S1 backscatter values. Both field measurements and SnowModel simulations suggested that S1 SAR was not sensitive to the initial snowpack warming phase on Grand Mesa. In the ripening and runoff phases, the diurnal cycle in S1 SAR co-polarized backscatter was affected by both surface melt/freeze as well as the conditions of the snowpack underneath (ripening or ripe). The ripening phase was associated with significant increases in morning backscatter values, likely due to volume scattering from surface melt/freeze crusts, as well as significant decreases in evening backscatter values associated with snowmelt. During the runoff phase, both morning and evening backscatter decreased compared to reference values. These unique S1 diurnal signatures, and their interpretations using field measurements and SnowModel outputs, highlight the capacities and limitations of S1 SAR to understand snow surface states and bulk phases, which may offer runoff forecasting or energy balance model validation or parameterization, especially useful in remote or sparsely-gauged alpine basins

Low Immunization Rate in Kidney Transplant Recipients Also After Dose 2 of the BNT162b2 Vaccine: Continue to Keep Your Guard up!

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Effect of Adjunct Metformin Treatment in Patients with Type-1 Diabetes and Persistent Inadequate Glycaemic Control. A Randomized Study

Despite intensive insulin treatment, many patients with type-1 diabetes (T1DM) have longstanding inadequate glycaemic control. Metformin is an oral hypoglycaemic agent that improves insulin action in patients with type-2 diabetes. We investigated the effect of a one-year treatment with metformin versus placebo in patients with T1DM and persistent poor glycaemic control.One hundred patients with T1DM, preserved hypoglycaemic awareness and HaemoglobinA(1c) (HbA(1c)) > or = 8.5% during the year before enrolment entered a one-month run-in on placebo treatment. Thereafter, patients were randomized (baseline) to treatment with either metformin (1 g twice daily) or placebo for 12 months (double-masked). Patients continued ongoing insulin therapy and their usual outpatient clinical care. The primary outcome measure was change in HbA(1c) after one year of treatment. At enrolment, mean (standard deviation) HbA(1c) was 9.48% (0.99) for the metformin group (n = 49) and 9.60% (0.86) for the placebo group (n = 51). Mean (95% confidence interval) baseline-adjusted differences after 12 months with metformin (n = 48) versus placebo (n = 50) were: HbA(1c), 0.13% (-0.19; 0.44), p = 0.422; Total daily insulin dose, -5.7 U/day (-8.6; -2.9), p<0.001; body weight, -1.74 kg (-3.32; -0.17), p = 0.030. Minor and overall major hypoglycaemia was not significantly different between treatments. Treatments were well tolerated.In patients with poorly controlled T1DM, adjunct metformin therapy did not provide any improvement of glycaemic control after one year. Nevertheless, adjunct metformin treatment was associated with sustained reductions of insulin dose and body weight. Further investigations into the potential cardiovascular-protective effects of metformin therapy in patients with T1DM are warranted.ClinicalTrials.gov NCT00118937

Analysis of the real EADGENE data set: Comparison of methods and guidelines for data normalisation and selection of differentially expressed genes (Open Access publication)

A large variety of methods has been proposed in the literature for microarray data analysis. The aim of this paper was to present techniques used by the EADGENE (European Animal Disease Genomics Network of Excellence) WP1.4 participants for data quality control, normalisation and statistical methods for the detection of differentially expressed genes in order to provide some more general data analysis guidelines. All the workshop participants were given a real data set obtained in an EADGENE funded microarray study looking at the gene expression changes following artificial infection with two different mastitis causing bacteria: Escherichia coli and Staphylococcus aureus. It was reassuring to see that most of the teams found the same main biological results. In fact, most of the differentially expressed genes were found for infection by E. coli between uninfected and 24 h challenged udder quarters. Very little transcriptional variation was observed for the bacteria S. aureus. Lists of differentially expressed genes found by the different research teams were, however, quite dependent on the method used, especially concerning the data quality control step. These analyses also emphasised a biological problem of cross-talk between infected and uninfected quarters which will have to be dealt with for further microarray studies