The Parent-Adolescent Relationship and Risk-Taking Behaviors Among Chinese Adolescents: The Moderating Role of Self-Control

The present study primarily aimed to examine whether self-control serves as a moderator in the associations between parent-adolescent relationships, including parental support and parent-adolescent conflict, and risk-taking behaviors among adolescents. The 917 Chinese adolescents whose mean age was 14.38 years (SD = 1.69) completed questionnaires effectively. The results indicated that the relationships between either parental support or parent-adolescent conflict and adolescent risk-taking behavior were moderated by self-control. Among those adolescents with lower levels of self-control, both higher levels of parent-adolescent conflict and lower levels of perceived parental support predicted more risk-taking behaviors, but their predicting roles got weakened with the increase of the level of self-control. Accordingly, good parent-adolescent relationship, particularly less parent-adolescent conflict, is critical for decreasing adolescent risk-taking. Otherwise, improving self-control is particularly helpful to those adolescents having more conflict with their parents or less parental support to decrease their risk-taking

Yi-Zhi-Fang-Dai Formula Protects against A β

Yi-Zhi-Fang-Dai formula (YZFDF) is an experiential prescription used to cure dementia cases like Alzheimer’s disease (AD). In this study, the main effective compounds of YZFDF have been identified from this formula, and the neuroprotective effect against Aβ1–42 oligomer of YZFDF has been tested in SH-SY5Y cells. Our results showed that YZFDF could increase cell viability and could attenuate endothelial reticula- (ER-) mediated apoptosis. Evidence indicated that protein folding and endothelial reticula stress (ERS) played an important role in the AD pathological mechanism. We further explored the expression of Hsp70, an important molecular chaperon facilitating the folding of other proteins, and Grp78, the marker protein of ERS in SH-SY5Y cells. Data told us that YZFDF pretreatment could influence the mRNA and protein expression of these two proteins. At last, we also found that YZFDF pretreatment could activate Akt in SH-SY5Y cells. All these above indicate that YZFDF could be a potent therapeutic candidate for AD treatment

Modulation of Synthetic Tracheal Grafts with Extracellular Matrix Coatings

Synthetic scaffolds for the repair of long-segment tracheal defects are hindered by insufficient biocompatibility and poor graft epithelialization. In this study, we determined if extracellular matrix (ECM) coatings improved the biocompatibility and epithelialization of synthetic tracheal grafts (syn-TG). Porcine and human ECM substrates (pECM and hECM) were created through the decellularization and lyophilization of lung tissue. Four concentrations of pECM and hECM coatings on syn-TG were characterized for their effects on scaffold morphologies and on in vitro cell viability and growth. Uncoated and ECM-coated syn-TG were subsequently evaluated in vivo through the orthotopic implantation of segmental grafts or patches. These studies demonstrated that ECM coatings were not cytotoxic and, enhanced the in vitro cell viability and growth on syn-TG in a dose-dependent manner. Mass spectrometry demonstrated that fibrillin, collagen, laminin, and nephronectin were the predominant ECM components transferred onto scaffolds. The in vivo results exhibited similar robust epithelialization of uncoated and coated syn-TG patches; however, the epithelialization remained poor with either uncoated or coated scaffolds in the segmental replacement models. Overall, these findings demonstrated that ECM coatings improve the seeded cell biocompatibility of synthetic scaffolds in vitro; however, they do not improve graft epithelialization in vivo

Parent–Child Relationships and Resilience Among Chinese Adolescents: The Mediating Role of Self-Esteem

The present study primarily aimed to examine whether self-esteem serves as a mediator in the associations between parent–child relationships, including parental support and parent–child conflict, and resilience among adolescents. Three hundred and four Chinese adolescents were surveyed with questionnaires and structural equation modeling was adopted to test the mediational hypothesis. The results indicated that the associations between parent–child relationships and adolescent resilience were primarily mediated by self-esteem and that parental support was more robustly linked with adolescent resilience than parent–adolescent conflict. The current study also tested a competitive mediational model in which resilience was the mediator and self-esteem was the outcome variable, and observed that this model was also well-established but inferior to the hypothesized mediational model. These findings extend our insight into the mechanisms underlying the associations among parent–child relationships, self-esteem, and resilience among adolescents and suggest that adolescent resilience promotion programs should focus on improving parental support in a family context and developing individual self-esteem

How do autistic severity and family functioning influence parental stress in caregivers of children with autism spectrum disorder in China? The important role of parental self-efficacy

IntroductionParental stress among primary caregivers of children with autism spectrum disorder (ASD) is a significant concern. While previous research indicates that both family and child factors substantially influence parental stress, a few studies have comprehensively examined these factors from family, parent, and child perspectives. Moreover, the psychological mechanisms underlying parental stress remain underexplored. MethodThis study obtained a valid sample of 478 primary caregivers of children diagnosed with ASD in China and employed mediation and moderated mediation analyses to investigate the relationships between family adaptability and cohesion (FAC), ASD severity, parental self-efficacy, and parental stress. ResultResults revealed that higher FAC was linked to reduced parental stress through increased parental self-efficacy. The indirect effect of parental self-efficacy was more substantial for caregivers of children with severe symptoms than those with mild symptoms. DiscussionThese findings offer insights into how FAC influences parental stress and underscore the importance of parental self-efficacy as a coping resource for mitigating parental stress. This study provides valuable theoretical and practical implications for understanding and addressing parental stress, particularly in families raising children with ASD

Visible and near-infrared photo-detector combining Polysilicon TFT and PbS quantum dots Semiconductor Technology for Ultra Large Scale Integrated Circuits and Thin Film Transistors VI

International audienc

The Biological Responses to Magnesium-Based Biodegradable Medical Devices

The biocompatibility of Magnesium-based materials (MBMs) is critical to the safety of biodegradable medical devices. As a promising metallic biomaterial for medical devices, the issue of greatest concern is devices’ safety as degrading products are possibly interacting with local tissue during complete degradation. The aim of this review is to summarize the biological responses to MBMs at the cellular/molecular level, including cell adhesion, transportation signaling, immune response, and tissue growth during the complex degradation process. We review the influence of MBMs on gene/protein biosynthesis and expression at the site of implantation, as well as throughout the body. This paper provides a systematic review of the cellular/molecular behavior of local tissue on the response to Mg degradation, which may facilitate a better prediction of long-term degradation and the safe use of magnesium-based implants through metal innovation

Role of Collagen in Airway Mechanics

Collagen is the most abundant airway extracellular matrix component and is the primary determinant of mechanical airway properties. Abnormal airway collagen deposition is associated with the pathogenesis and progression of airway disease. Thus, understanding how collagen affects healthy airway tissue mechanics is essential. The impact of abnormal collagen deposition and tissue stiffness has been an area of interest in pulmonary diseases such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease. In this review, we discuss (1) the role of collagen in airway mechanics, (2) macro- and micro-scale approaches to quantify airway mechanics, and (3) pathologic changes associated with collagen deposition in airway diseases. These studies provide important insights into the role of collagen in airway mechanics. We summarize their achievements and seek to provide biomechanical clues for targeted therapies and regenerative medicine to treat airway pathology and address airway defects

Role of Collagen in Airway Mechanics

Collagen is the most abundant airway extracellular matrix component and is the primary determinant of mechanical airway properties. Abnormal airway collagen deposition is associated with the pathogenesis and progression of airway disease. Thus, understanding how collagen affects healthy airway tissue mechanics is essential. The impact of abnormal collagen deposition and tissue stiffness has been an area of interest in pulmonary diseases such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease. In this review, we discuss (1) the role of collagen in airway mechanics, (2) macro- and micro-scale approaches to quantify airway mechanics, and (3) pathologic changes associated with collagen deposition in airway diseases. These studies provide important insights into the role of collagen in airway mechanics. We summarize their achievements and seek to provide biomechanical clues for targeted therapies and regenerative medicine to treat airway pathology and address airway defects