Analisis Metode Kepemimpinan dan Motivasi Kerja terhadap Peningkatan Produktivitas Kerja Pegawai di Kantor Balai Pelatihan Kesehatan Provinsi Sulawesi Utara

Kepemimpinan seorang pemimpin dalam suatu organisasi sangat penting, karena pemimpin memiliki peranan yang strategis dalam mencapai tujuan organisasi yang tertuang dalam visi dan misi organisasi. Kepemimpinan ialah kemampuan dan keterampilan seseorang atau individu yang menduduki jabatan sebagai pimpinan satuan kerja, untuk mempengaruhi perilaku orang lain terutama bawahannya, untuk berfikir dan bertindak sedemikian rupa, sehingga melalui perilaku yang positif tersebut dapat memberikan sumbangsih nyata dalam pencapaian tujuan organisasi. Penelitian ini bertujuan untuk mengetahui pengaruh metode kepemimpinan dan motivasi kerja terhadap peningkatan produktivitas kerja pegawai di kantor BAPELKES provinsi Sulawesi Utara. Metode Analisis menggunakan regresi berganda dengan uji hipotesis serta uji asumsi klasik. Hasil analisis menunjukan secara simultan atau parsial, metode kepemimpinan dan motivasi kerja berpengaruh signifikan terhadap produktivitas kerja karyawan. Pimpinan BAPELKES perlu meningkatkan atau memperhatikan metode kepemimpinan yang diterapkan, dan mengevaluasi kembali Kepemimpinan serta metode yang diterapkan agar dapat menciptakan suasana yang nyaman pada karyawan dalam bekerja. Kata kunci: metode kepemimpinan, motivasi, produktivitas kerj

\u3ci\u3eEl Milagro\u3c/i\u3e: The Miracle of Service Learning on the Border

In 2000, DoZa Ana Branch Community College (DABCC) received a grant from the American Association of Community Colleges Broadening Horizons through Service Learning program to develop service learning in southern New Mexico. Poised on the United States- Mexico border, DABCC serves a population that includes 40% colonia residents. Colonias are communities within 150 miles of the border that lack basic infrastructure such as paved roads, water and sewage treatment facilities, and adequate housing. DABCC has developed community partnerships with colonia residents and with agencies that provide services within the colonias. In their presentation, a DABCC team will describe service learning projects in technical, vocational, and developmental courses that place students at the core of learning and service in their own community. They will provide a list of courses that have a service learning component, a brochure describing El Milagro Service Learning Initiative, photos from service learning activities, and a brief video of colonia life

Ectopia Cordis in a 35 Day Old Human Embryo

One of the major, though fortunately rare, abnormalities of human intrauterine development is a condition known as ectopia cordis. It was first described by the Swiss poet, physician and naturalist Haller in 1706. Arey (1954) briefly characterizes ectopia cordis as an abnormality in which the heart protrudes from the anterior body wall between the widely separated halves of the sternum, and comes to lie exposed on the surface of the chest. Others (cf. De Abbot) have described ectopia cordis as an abnormality in which the heart is malpositioned, high up in the chest, protruding out from the body in the pectoral area, or even displaced into the abdominal cavity

Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy

Clinical translation of polymer‐based nanocarriers for systemic delivery of RNA has been limited due to poor colloidal stability in the blood stream and intracellular delivery of the RNA to the cytosol. To address these limitations, this study reports a new strategy incorporating photocrosslinking of bioreducible nanoparticles for improved stability extracellularly and rapid release of RNA intracellularly. In this design, the polymeric nanocarriers contain ester bonds for hydrolytic degradation and disulfide bonds for environmentally triggered small interfering RNA (siRNA) release in the cytosol. These photocrosslinked bioreducible nanoparticles (XbNPs) have a shielded surface charge, reduced adsorption of serum proteins, and enable superior siRNA‐mediated knockdown in both glioma and melanoma cells in high‐serum conditions compared to non‐crosslinked formulations. Mechanistically, XbNPs promote cellular uptake and the presence of secondary and tertiary amines enables efficient endosomal escape. Following systemic administration, XbNPs facilitate targeting of cancer cells and tissue‐mediated siRNA delivery beyond the liver, unlike conventional nanoparticle‐based delivery. These attributes of XbNPs facilitate robust siRNA‐mediated knockdown in vivo in melanoma tumors colonized in the lungs following systemic administration. Thus, biodegradable polymeric nanoparticles, via photocrosslinking, demonstrate extended colloidal stability and efficient delivery of RNA therapeutics under physiological conditions, and thereby potentially advance systemic delivery technologies for nucleic acid‐based therapeutics

Thyroid hormone inhibition in L6 myoblasts of IGF-I-mediated glucose uptake and proliferation: New roles for integrin αvβ3

Thyroid hormones L-thyroxine (T4) and 3,3′,5-triiodo-L-thyronine (Se

Patterns in blood pressure medication use in US incident dialysis patients over the first 6 months.

BACKGROUND: Several observational studies have evaluated the effect of a single exposure window with blood pressure (BP) medications on outcomes in incident dialysis patients, but whether BP medication prescription patterns remain stable or a single exposure window design is adequate to evaluate effect on outcomes is unclear. METHODS: We described patterns of BP medication prescription over 6 months after dialysis initiation in hemodialysis and peritoneal dialysis patients, stratified by cardiovascular comorbidity, diabetes, and other patient characteristics. The cohort included 13,072 adult patients (12,159 hemodialysis, 913 peritoneal dialysis) who initiated dialysis in Dialysis Clinic, Inc., facilities January 1, 2003-June 30, 2008, and remained on the original modality for at least 6 months. We evaluated monthly patterns in BP medication prescription over 6 months and at 12 and 24 months after initiation. RESULTS: Prescription patterns varied by dialysis modality over the first 6 months; substantial proportions of patients with prescriptions for beta-blockers, renin angiotensin system agents, and dihydropyridine calcium channel blockers in month 6 no longer had prescriptions for these medications by month 24. Prescription of specific medication classes varied by comorbidity, race/ethnicity, and age, but little by sex. The mean number of medications was 2.5 at month 6 in hemodialysis and peritoneal dialysis cohorts. CONCLUSIONS: This study evaluates BP medication patterns in both hemodialysis and peritoneal dialysis patients over the first 6 months of dialysis. Our findings highlight the challenges of assessing comparative effectiveness of a single BP medication class in dialysis patients. Longitudinal designs should be used to account for changes in BP medication management over time, and designs that incorporate common combinations should be considered

Inland spring mounds

[Extract] The Great Artesian Basin is the world's largest artesian basin, with inflow mainly at its eastern Queensland margin, and outflows along its southern and western margins at mound springs formed by the build-up of precipitatesand aeolian sediments (Boyd 1990a).The water flowing from these point sources of permanent fresh water in a largely waterless environment generally evaporates or soaks into the soil within tens or hundreds of metres. Occasionally, there is sufficient water to form permanent swamps, some with growing peat

Inland spring mounds

[Extract] The Great Artesian Basin is the world's largest artesian basin, with inflow mainly at its eastern Queensland margin, and outflows along its southern and western margins at mound springs formed by the build-up of precipitatesand aeolian sediments (Boyd 1990a).The water flowing from these point sources of permanent fresh water in a largely waterless environment generally evaporates or soaks into the soil within tens or hundreds of metres. Occasionally, there is sufficient water to form permanent swamps, some with growing peat

The Beating heart : environmental history of Australia's deserts

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