Men, masculinity and male gender role socialisation : implications for men's mental health and psychological help seeking behaviour

The work comprises of three sections, Section A: Literature review This section reviews men's underutilisation of professional health care services and brings together the extant literature on men's help seeking for psychological difficulties. This is discussed specifically in relation to theories of male gender role socialisation and male development. Section B: Empirical Paper. Introduction: Men’s reluctance to access health care services has been under researched even though it has been identified as a potentially important predictor of poorer health outcomes among men. Male gender role socialisation and male development may be important in accounting for men’s underutilisation of mental health service in the UK. Method: A cross-sectional online survey was used to administer standardised self-report measures that were subject to regression analysis. Five hundred and eighty-one men from the UK general population completed the survey and 434 participants formed the final regression model sample. Results: Men who score higher on measures of traditional masculine ideology, normative alexithymia and fear of intimacy reported more negative attitudes towards seeking professional psychological help. Normative alexithymia accounted for the variance in help seeking previously observed by fear of intimacy during regression modelling. Sexuality and ethnicity also significantly accounted for a proportion of unique variance in men’s help seeking attitudes. People who had received previous support from a mental health professional showed more positive attitudes towards seeking psychological help. Conclusions: Men’s attitudes towards seeking psychological help were closely related to traditional masculine ideology and normative alexithymia. A degree of content or construct overlap may exist between normative alexithymia and fear of intimacy in men. Limitations of this study and implications for future research are discussed. Section C: Critical Review. This section provides critical appraisal and reflection on the study and research process. Personal learning is discussed alongside clinical implications and ideas for further research.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Elementary simulation of tethered Brownian motion

We describe a simple numerical simulation, suitable for an undergraduate project (or graduate problem set), of the Brownian motion of a particle in a Hooke-law potential well. Understanding this physical situation is a practical necessity in many experimental contexts, for instance in single molecule biophysics; and its simulation helps the student to appreciate the dynamical character of thermal equilibrium. We show that the simulation succeeds in capturing behavior seen in experimental data on tethered particle motion.Comment: Submitted to American Journal of Physic

Pigmented villous nodular synovitis mimicking metastatic melanoma on PET-CT

AbstractINTRODUCTIONPositron Emission Tomography – Computed Tomography (PET-CT) is routinely utilized in the management of melanoma, either as a part of staging workup or during surveillance. Since melanomas have a high metastatic potential, any FDG avid lesion is considered suspicious for recurrence. We report a case of a FDG avid lesion, diagnosed during melanoma surveillance, its management and review of literature.PRESENTATION OF CASEA 58 year-old-male underwent wide local excision for melanoma of the left cheek, and one year post-operatively a PET-CT that revealed a hypermetabolic focus in his right subscapularis muscle, which upon resection was diagnosed as Pigmented Villonodular Synovitis (PVNS).DISCUSSIONPVNS is a rare benign giant cell tumor that requires no additional treatment in asymptomatic individuals. PET-CT is used for staging and surveillance of numerous malignancies, including melanoma. A hypermetabolic lesion on a PET-CT scan in the setting of malignancy is always suspicious for recurrence.CONCLUSIONThe surgeon is reminded of a uncommon benign FDG avid lesion. Typical location, nonspecific symptoms and characteristic imaging findings help cue in the diagnosis of PVNS and a tissue diagnosis will establish the diagnosis, thus avoiding unnecessarily aggressive surgical management

Relative baryon-dark matter velocities in cosmological zoom simulations

Supersonic relative motion between baryons and dark matter due to the decoupling of baryons from the primordial plasma after recombination affects the growth of the first small-scale structures. Large box sizes (greater than a few hundred Mpc) are required to sample the full range of scales pertinent to the relative velocity, while the effect of the relative velocity is strongest on small scales (less than a few hundred kpc). This separation of scales naturally lends itself to the use of `zoom' simulations, and here we present our methodology to self-consistently incorporate the relative velocity in zoom simulations, including its cumulative effect from recombination through to the start time of the simulation. We apply our methodology to a large-scale cosmological zoom simulation, finding that the inclusion of relative velocities suppresses the halo baryon fraction by $46$--$23$ per cent between $z=13.6$ and $11.2$, in qualitative agreement with previous works. In addition, we find that including the relative velocity delays the formation of star particles by $\sim 20 {~\rm Myr}$ Myr on average (of the order of the lifetime of a $\sim 9~{\rm M}_\odot$ Population III star) and suppresses the final stellar mass by as much as $79$ per cent at $z=11.2$.Comment: 14 pages, 12 figures. Accepted for publication in MNRA

Life in Hot Carbon Monoxide: The Complete Genome Sequence of Carboxydothermus hydrogenoformans Z-2901

We report here the sequencing and analysis of the genome of the thermophilic bacterium Carboxydothermus hydrogenoformans Z-2901. This species is a model for studies of hydrogenogens, which are diverse bacteria and archaea that grow anaerobically utilizing carbon monoxide (CO) as their sole carbon source and water as an electron acceptor, producing carbon dioxide and hydrogen as waste products. Organisms that make use of CO do so through carbon monoxide dehydrogenase complexes. Remarkably, analysis of the genome of C. hydrogenoformans reveals the presence of at least five highly differentiated anaerobic carbon monoxide dehydrogenase complexes, which may in part explain how this species is able to grow so much more rapidly on CO than many other species. Analysis of the genome also has provided many general insights into the metabolism of this organism which should make it easier to use it as a source of biologically produced hydrogen gas. One surprising finding is the presence of many genes previously found only in sporulating species in the Firmicutes Phylum. Although this species is also a Firmicutes, it was not known to sporulate previously. Here we show that it does sporulate and because it is missing many of the genes involved in sporulation in other species, this organism may serve as a “minimal” model for sporulation studies. In addition, using phylogenetic profile analysis, we have identified many uncharacterized gene families found in all known sporulating Firmicutes, but not in any non-sporulating bacteria, including a sigma factor not known to be involved in sporulation previously

In search of CurveSwap: Measuring elliptic curve implementations in the wild

We survey elliptic curve implementations from several vantage points. We perform internet-wide scans for TLS on a large number of ports, as well as SSH and IPsec to measure elliptic curve support and implementation behaviors, and collect passive measurements of client curve support for TLS. We also perform active measurements to estimate server vulnerability to known attacks against elliptic curve implementations, including support for weak curves, invalid curve attacks, and curve twist attacks. We estimate that 0.77% of HTTPS hosts, 0.04% of SSH hosts, and 4.04% of IKEv2 hosts that support elliptic curves do not perform curve validity checks as specified in elliptic curve standards. We describe how such vulnerabilities could be used to construct an elliptic curve parameter downgrade attack called CurveSwap for TLS, and observe that there do not appear to be combinations of weak behaviors we examined enabling a feasible CurveSwap attack in the wild. We also analyze source code for elliptic curve implementations, and find that a number of libraries fail to perform point validation for JSON Web Encryption, and find a flaw in the Java and NSS multiplication algorithms

Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues

Genetic variants that modulate gene expression levels play an important role in the etiology of human diseases and complex traits. Although large-scale eQTL mapping studies routinely identify many local eQTLs, the molecular mechanisms by which genetic variants regulate expression remain unclear, particularly for distal eQTLs, which these studies are not well powered to detect. Here, we leveraged all variants (not just those that pass stringent significance thresholds) to analyze the functional architecture of local and distal regulation of gene expression in 15 human tissues by employing an extension of stratified LD-score regression that produces robust results in simulations. The top enriched functional categories in local regulation of peripheral-blood gene expression included coding regions (11.41×), conserved regions (4.67×), and four histone marks (p < 5 × 10 -5 for all enrichments); local enrichments were similar across the 15 tissues. We also observed substantial enrichments for distal regulation of peripheral-blood gene expression: coding regions (4.47×), conserved regions (4.51×), and two histone marks (p < 3 × 10 -7 for all enrichments). Analyses of the genetic correlation of gene expression across tissues confirmed that local regulation of gene expression is largely shared across tissues but that distal regulation is highly tissue specific. Our results elucidate the functional components of the genetic architecture of local and distal regulation of gene expression