Prevalence and Risk Factors of Human Papillomavirus (HPV) Infection in Southern Chinese Women – A Population-Based Study

Background: Persistent high-risk type Human papillomavirus (HPV) infection is recognized as a necessary cause of cervical cancer. This study aimed to compare the HPV prevalence and risk factors between women residing in Hong Kong (HK) and Guangzhou (GZ) region of China. Methodology/Principal Findings: A total of 1,570 and 1,369 women were recruited from HK and GZ, respectively. The cytology samples were collected and tested for HPV infection. The overall and type-specific HPV prevalence and the potential risk factors for acquisition of HPV infection were studied. Women with normal cytology in the GZ cohort had significantly higher HPV prevalence (10%) than those in the HK cohort (6.2%, p<0.001). The patterns of the age-specific HPV prevalence were also different between the two cohorts. In the HK cohort, women at the age of 20-29 years old had the highest prevalence and a second peak was observed in the age of ≥60 years old. In the GZ cohort, the highest HPV prevalence was also observed in 20-29 years old but declined as the age increased and a second peak was not seen. HPV16 and HPV52 were the most common high-risk types found in the HK and GZ cohorts, respectively. Age was the most consistently observed independent risk factor for HPV infection in the HK, while the number of sexual partners had association in the GZ cohort. Conclusions/Significance: Our study provides the current status and the epidemiological characteristics of HPV prevalence in Southern Chinese women. The results strongly suggested that population education and the effective cervical cancer screening would be vital in the prevention of cervical cancer. © 2011 Liu et al.published_or_final_versio

Genetic Drivers of Heterogeneity in Type 2 Diabetes Pathophysiology

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P \u3c 5 × 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P &lt; 5 × 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.</p

Beyond Reading and Writing: How Volunteer Tutors Develop Their Practice with Learners in Adult Literacy Programs in Ontario

Although volunteers account for a considerable portion of the instructors and tutors delivering adult literacy programs, volunteers are rarely the focus of research. Focusing specifically on the narratives of volunteers, this study fills this research gap by examining what the volunteers do in the tutoring sessions as well as their experience as volunteers. This study uses Bourdieuâ s theory of practice as the theoretical framework to gain a deeper understanding of the rationale behind the volunteersâ role as policy actors in the policy process. Three volunteers from an adult literacy program in Ontario shared their experiences in this study from which four composite stories emerged: before and after volunteering; what happened during the tutoring sessions; relationships between tutors and learners; and contrasts. These composite stories highlight the dynamics between agency and structure, the importance of perspective in understanding the relationships and the potential for social and policy change through reflexive practice.M.A

Only in a Collective: A Narrative Inquiry into Leadership in a Collective Organizational Structure

Parkdale Project Read (PPR) has been providing adult literacy programming in the Parkdale neighbourhood west of Toronto, Canada since the 1980s. The staff at PPR work as a collective in which everyone shares the same title and pay rate as part of a commitment to equality, democracy and collaboration. The collective structure serves as an alternative to hierarchical models. Three research questions guided this study to understand leadership in a collective structure: (1) How do the staff members who work in a collective organizational structure share the work of leadership as a group; (2) What is considered the work of leadership in a collective in terms of the staff members’ day-to-day work; and (3) How does the collective organizational structure influence the staff members’ understanding and performance of the work of leadership as individuals and as a group. Using narrative inquiry as methodology which included interviews, observations and a group writing exercise, I worked with eight participants representing all four of the current collective members at PPR (at the time of the study) and four former collective members. The participants told their stories of working in the collective and of sharing leadership with others in the collective. In retelling the stories shared with me by the participants and drawing from Bourdieu’s thinking tools of habitus, capital and field, I discuss how the collective structure influences the understanding and performance of leadership by the collective members as individuals and as a group through the way they relate to each other. At the same time, the collective members change the way the collective operates with their actions and relationships. The results from this study highlight how a collective shares leadership among its members and challenge how we typically conceptualize leadership by illustrating the dynamic interactions between agency and structure.Ph.D

Las mujeres y el tabaco en la Unión Europea

A lo largo de las últimas décadas, la prevalencia del tabaquismo ha seguido en la Unión Europea tendencias diferentes según el sexo. Mientras que entre los varones la prevalencia ha disminuido notablemente, entre las mujeres se ha incrementado o se ha estancado. En algunos países en que estos cambios se iniciaron más precozmente, la prevalencia del tabaquismo es hoy mayor entre las mujeres que entre los varones. Este documento cuantifica estas tendencias, con referencia a la situación española. En 1995, fumaban 60 millones de hombres y 42 millones de mujeres en la Unión Europea. El 48% de las fumadoras consumían cigarrillos light, lo que supone veinte millones de mujeres que los utilizan. Hay documentos de la industria del tabaco que indican que la promoción de cigarrillos light tiene como intención tranquilizar a sus clientes y frenar a quienes se preocupan por el mantenimiento de su salud y se plantean dejar de fumar. Hay datos que confirman que esta política consigue sus objetivos y que las concepciones erróneas de los fumadores sobre los cigarrillos light puede hacerles persistir en el consumo. Existen datos que indican que el tabaco puede jugar un papel en el control del peso. Las mujeres están más preocupadas por su peso que los hombres, y para las mujeres jóvenes la imagen corporal es muy importante. Éstas tienen a menudo la percepción de tener exceso de peso. Aunque es más común el miedo al sobrepeso que el exceso de peso real, la evidencia sugiere que el temor a ganar peso puede mantener a las mujeres en el hábito de fumar, y que las consideraciones sobre cómo mantener el control del peso influyen en las mujeres jóvenes al comenzar a fumar. El consejo sobre cómo controlar el peso debería formar parte de los programas de tratamiento del tabaquismo dirigidos a las mujeres. Además, cualquier intervención preventiva sobre mujeres adolescentes fumadoras debería abordar la cuestión del aumento de peso

Maintenir un équilibre entre cohérence et flexibilité : les défis et les occasions qui surviennent lors d’une étude longitudinale pancanadienne de jeunes participants dans des entreprises sociales d’insertion par le travail

Longitudinal studies conducted within the social economy have the potential to provide useful insights by tracing participant experiences and illuminating long-term outcomes of program interventions. However, longitudinal studies are challenging, not only due to retention of participants, but also when a longitudinal study covers a broad geographic area. The authors collaborated in a five-year pan-Canadian longitudinal study following youth participants in work-integration social enterprise (WISE) training programs. This article traces the experiences of study teams in Ontario and Greater Vancouver, providing accounts of the approaches and challenges encountered when working in geographically and socio-economically diverse locales over time with youth participants facing social marginalization. This article highlights three aspects of data collection—recruitment, retention, and research methods and logistics—offering insights into how each team devised its own strategies to fit with local circumstances while maintaining consistency across research sites.Des études longitudinales ayant l’économie sociale comme cadre peuvent fournir des données utiles en répertoriant les expériences de participants à divers programmes et en illuminant les effets à long terme d’interventions dans ces programmes. Cependant, les études longitudinales ne sont pas faciles à effectuer, non seulement en ce qui a trait à la rétention de participants, mais aussi en ce qui a trait aux vastes étendues géographiques qu’elles peuvent couvrir. Les auteurs ont soulevé ce défi en collaborant à une étude longitudinale pancanadienne de cinq ans qui a consisté à suivre des jeunes participant à des programmes de formation offerts par des entreprises sociales d’insertion par le travail (ESIT). Cet article examine les expériences d’équipes de recherche en Ontario et dans le Grand Vancouver, fournissant un compte rendu des approches et défis relatifs à leur travail dans la durée auprès de jeunes participants confrontés à la marginalisation sociale dans des contextes d’une grande diversité géographique et socioéconomique. En guise de conclusion, cet article souligne trois aspects de la collecte de données—à savoir les méthodes et la logistique pertinentes pour le recrutement, la rétention et la recherche—et offre un aperçu de la manière dont chaque équipe a développé ses propres stratégies adaptées aux circonstances locales en s’efforçant de maintenir une certaine cohérence d’un site de recherche à l’autre

Las mujeres y el tabaco en la Unión Europea

A lo largo de las últimas décadas, la prevalencia del tabaquismo ha seguido en la Unión Europea tendencias diferentes según el sexo. Mientras que entre los varones la prevalencia ha disminuido notablemente, entre las mujeres se ha incrementado o se ha estancado. En algunos países en que estos cambios se iniciaron más precozmente, la prevalencia del tabaquismo es hoy mayor entre las mujeres que entre los varones. Este documento cuantifica estas tendencias, con referencia a la situación española. En 1995, fumaban 60 millones de hombres y 42 millones de mujeres en la Unión Europea. El 48% de las fumadoras consumían cigarrillos light, lo que supone veinte millones de mujeres que los utilizan. Hay documentos de la industria del tabaco que indican que la promoción de cigarrillos light tiene como intención tranquilizar a sus clientes y frenar a quienes se preocupan por el mantenimiento de su salud y se plantean dejar de fumar. Hay datos que confirman que esta política consigue sus objetivos y que las concepciones erróneas de los fumadores sobre los cigarrillos light puede hacerles persistir en el consumo. Existen datos que indican que el tabaco puede jugar un papel en el control del peso. Las mujeres están más preocupadas por su peso que los hombres, y para las mujeres jóvenes la imagen corporal es muy importante. Éstas tienen a menudo la percepción de tener exceso de peso. Aunque es más común el miedo al sobrepeso que el exceso de peso real, la evidencia sugiere que el temor a ganar peso puede mantener a las mujeres en el hábito de fumar, y que las consideraciones sobre cómo mantener el control del peso influyen en las mujeres jóvenes al comenzar a fumar. El consejo sobre cómo controlar el peso debería formar parte de los programas de tratamiento del tabaquismo dirigidos a las mujeres. Además, cualquier intervención preventiva sobre mujeres adolescentes fumadoras debería abordar la cuestión del aumento de peso.Over the last decades, the prevalence of smoking in the European Union has followed different trends by sex. While the prevalence has declined for men, it has increased or is stable for women. In some countries where these changes took place earlier, the prevalence of smoking is now higher among women than among men. This document provides quantitative data for these trends in the European Union, with special reference to the situation in Spain. In 1995 there were 60 million men and 42 million women smokers in the European Union. Up to 48% of female smokers used light cigarettes, that is 20 million women. There are documents from the tobacco industry showing that the goal of the promotion of light cigarettes is to reassure their clients and to keep as smokers those concerned about their health who are considering the possibility of quitting. There is evidence confirming that this policy is successful, and that the misconceptions of smokers about light cigarettes deter them from quitting. There is evidence on the role of smoking in weight control. Women are more concerned than men about their weight, and for young women body image is very relevant. Young girls often have the perception that they are overweight. Although fear of being overweight is more common than actual overweight, the evidence suggests that being afraid of gaining weight plays a role in keeping women as smokers, and that young girls begin smoking taking into consideration weight issues. The advice on how to maintain weight should be included in any smoking cessation program for women. Any preventive action for teen age smokers should include weight control issues