Molecular epidemiology of endemic Human T-Lymphotropic virus 1 (HTLV-1) in a community in rural Guinea-Bissau

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Mobile real-time surveillance of Zika virus in Brazil

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2016-11-29T17:59:25Z No. of bitstreams: 1 Faria N R Mobil real....pdf: 357343 bytes, checksum: 5e7279515aa41c01d0c75ed09a95c5b2 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2016-11-29T18:43:34Z (GMT) No. of bitstreams: 1 Faria N R Mobil real....pdf: 357343 bytes, checksum: 5e7279515aa41c01d0c75ed09a95c5b2 (MD5)Made available in DSpace on 2016-11-29T18:43:34Z (GMT). No. of bitstreams: 1 Faria N R Mobil real....pdf: 357343 bytes, checksum: 5e7279515aa41c01d0c75ed09a95c5b2 (MD5) Previous issue date: 2016-09-29University of Oxford. Department of Zoology. South Parks Road. Oxford, UK.University of Sao Paulo. Department of Infectious Diseases and Institute of Tropical Medicine. São Paulo, BrasilMinistry of Health. Evandro Chagas Institute. Center for Technological Innovation. Ananindeua, PA, Brasil / University of Texas Medical Branch. Department of Pathology. Galveston, USAFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Birmingham. Institute of Microbiology and Infection. Birmingham, UK.The World Health Organization has declared Zika virus an international public health emergency. Knowledge of Zika virus genomic epidemiology is currently limited due to challenges in obtaining and processing samples for sequencing. The ZiBRA project is a United Kingdom-Brazil collaboration that aims to improve this situation using new sequencing technologies

Molecular Epidemiology of Endemic Human T-Lymphotropic Virus Type 1 in a Rural Community in Guinea-Bissau

Human T-Lymphotropic Virus type 1 (HTLV-1) affects millions of people worldwide. It is very similar to Simian T-Lymphotropic Virus, a virus that circulates in monkeys. HTLV-1 causes a lethal form of leukemia (Adult T-cell Leukemia) and a debilitating neurological syndrome (HTLV-associated myelopathy/tropical spastic paraparesis) in approximately 5% of infected people. Based on sequence variation, HTLV-1 can be divided into 7 subtypes (1a–1g) with the Cosmopolitan subtype 1a further subdivided into subgroups (A–E). We examined HTLV-1 diversity in a rural area in Guinea-Bissau, a country in West Africa with a high HTLV-1 prevalence (5%). We found that most viruses belong to the Cosmopolitan subtype 1a, subgroup D, but 2 viruses belonged to subtype 1g. This subtype had thus far only been found in monkey hunters in Cameroon, who were probably recently infected by monkeys. Our findings indicate that this subtype has spread beyond Central Africa. An important, unresolved question is whether persons with this subtype were infected by monkeys or through human-to-human transmission

RegaDB: Community-driven data management and analysis for infectious diseases

Summary: RegaDB is a free and open source data management and analysis environment for infectious diseases. RegaDB allows clinicians to store, manage and analyse patient data, including viral genetic sequences. Moreover, RegaDB pr