Anterior Hepatic Transection for Caudate Lobectomy

Resection of the caudate lobe (segment I- dorsal sector, segment IX- right paracaval region, or both) is often technically difficult due to the lobe’s location deep in the hepatic parenchyma and because it is adjacent to the major hepatic vessels (e.g., the left and middle hepatic veins)

Does bilioenteric anastomosis impair results of liver resection in primary intrahepatic lithiasis?

AIM: To evaluate the long-term results of liver resection for the treatment of primary intrahepatic lithiasis. Prognostic factors, especially the impact of bilioenteric anastomosis on recurrence of symptoms were assessed

Liver histologic analysis.

<p>Liver histologic analysis.</p

Aminotransferases four hours after liver reperfusion.

<p>1A –AST—aspartate aminotransferase; 1B –ALT—alanine aminotransferase CONTR—Control Group (n = 10); SAL—Saline Group (n = 15); TD—Trisulfated Disaccharide Group (n = 15). Data are expressed as mean values * (SAL vs TD and SAL vs CONTR) p<0.05.</p

Liver MDA and Lung microvascular permeability (EBD).

<p>3A –Liver MDA. Data are expressed as mean values * (SAL vs TD and SAL vs CONTR) p<0.05; 3B—Lung microvascular permeability (EBD) *(CONT vs SAL and CONTR vs TD) p<0.05. (TD vs SAL) NS. CONTR—Control Group; SAL (n = 10)–Saline Group (n = 15); TD—Trisulfated Disaccharide Group (n = 15). NS: No Significance.</p

Liver mitochondrial function.

<p>2A –RCR—Respiratory control rate * (TD vs SAL) p<0.05; # (CONTR vs SAL) p<0,05; 2B—ADP/O—ADP/Oxygen ratio * (SAL vs TD and SAL vs CONTR) p<0.05; 2C –S3—State 3 respiration * (SAL vs TD and SAL vs CONTR) p<0.05; 2D –S4—State 4 respiration NS: No Significance. CONTR—Control Group (n = 10); SAL—Saline Group; TD (n = 15)—Trisulfated Disaccharide Group (n = 15). Data are expressed as mean values.</p

TD effect on thapsigargin-induced cytosolic calcium increase in liver cells (n = 3).

<p>Panel A—Images of 340/380 nm fluorescence ratio using a non-true color scale. Scale bars—50 μm; Time shown in white inside each frame; Panel B—Relative quantification of changes in calcium levels. Arrows indicate additions. THAP—4 μM thapsigargin; IONO—0.25 μM ionomycin; TD—30 μM trisulfated disaccharide.</p