Aporfinoides en hojas de oxandra longipetala r. e. fr. (annonaceae)

El estudio químico del extracto de alcaloides totales, realizado por el método clásico, de las hojas de Oxandra longipetala R. E. Fr., colectada en el departamento de Córdoba, Colombia, permitió el aislamiento e identificación de los alcaloides oxoaporfínicos lysicamina, O-metilmoschatolina, atherospermidina y liriodenina, junto con las aporfinas nornuciferina y anonaina. Las estructuras fueron elucidadas por métodos espectroscópicos (IR, RMN-1H, RMN-13C, experimentos 2D, espectrometría de masas) y por comparación con datos de la literatura

Azafluorenonas en corteza de oxandra longipetala r. e. fr. (annonaceae)

El estudio químico del extracto de alcaloides totales, realizado por el método clásico, de la corteza de Oxandra longipetala R. E. Fr., colectada en el departamento de Córdoba, Colombia, permitió el aislamiento e identificación de cuatro alcaloides de tipo azafluorenona: ursulina, isoursulina, O-metilmacondina y macondina, junto con las oxoaporfinas lysicamina, O-metilmoschatolina, y liriodenina. Las estructuras fueron elucidadas por métodos espectroscópicos (UV, IR, RMN-1H, RMN-13C, experimentos 2D, espectrometría de masas) y por comparación con datos de la literatura

Metabolitos aislados de raputia heptaphylla y esenbeckia alata (rutaceae) y síntesis de precursores de análogos de alcaloides quinolínicos

Previous studies on the Esenbeckia alata and Raputia heptaphylla,both species belonging to the Rutaceae family, have shownimportant results with respect to their chemistry. These species havesecondary metabolites (coumarins and alkaloids mainly), which act aschemotaxonomic markers. This paper presents, for the first time, the phytochemicalwork and isolated metabolites in these species: four coumarins:bergapten, xanthyletin, xanthotoxin, 3-isoprenyl-4-methoxy-coumarin;four alkaloids: skinmianine, kokusaginine, dictamnine, and 1-methyl-2-methoxy-4-quinolone; two lignans: sesamin and mesodihydroguaiareticacid; two sterols: -sitosterol, stigmasterol; and a pentacyclic triterpene:lupeol that have been isolated from leaves of E. alata. Five alkaloids7-methoxy-2,2-dimethyl-2,6-dihidro-piran[3,2,c] quinolin-5-one, flindersiamine,skinmianine, kokusaginine and dictamnine that have been isolatedfrom leaves of R. heptaphylla. Moreover, it presents a new method byobtaining quinolone alkaloid analogue precursors trough the condensationsof Mannich adduct vinylogous and aldehydes followed by radicalcyclization to obtain products with high regio- and stereoselectivity.

In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants

The in vitro anti-inflammatory effects of seven known lignans and one dihydrochalcone isolated from the leaves of two Lauraceae species (Pleurothyrium cinereum and Ocotea macrophylla), were evaluated through the inhibition of COX-1, COX-2, 5-LOX and the aggregation of rabbit platelets induced by PAF, AA and ADP. (+)-de-4"-O--methylmagnolin 4 was found to be a potent COX-2/5-LOX dual inhibitor and PAF-antagonist (COX-2 IC50 2.27 µM; 5-LOX IC50 5.05 µM; PAF IC50 2.51 µM). However, all compounds exhibited an activity at different levels, indicating good anti-inflammatory properties to be considered in further structural optimization studies.<br>Os efeitos anti-inflamatórios in vitro de sete conhecidos lignanos e uma dihidrocalcona isolados das folhas de duas espécies da família Lauraceae (Pleurothyrium cinereum e Ocotea macrophylla) foram avaliados por meio da inibição da COX1, COX-2, 5-LOX e agregação de plaquetas de coelhos induzida por PAF, AA e ADP. A (+)-4"-O-metilmagnolina-4 foi encontrada como mais potente inibidora tanto da COX-2 quanto de 5-LOX e antagonista de PAF (COX-2 IC50 2,27 µM; 5- LOX IC50 5,05 µM; PAF IC50 2,51 µM). Entretanto, todos compostos mostram uma atividade em intensidades diferentes, indicando boas propriedades anti-inflamátorias a serem consideradas para futuros estudos de modificações e otimização estruturais

Tetranortriterpenoids and Dihydrocinnamic Acid Derivatives from Hortia colombiana

A novel tetranortriterpenoid and two dihydrocinnamic acid derivatives were obtained from the wood of Hortia colombiana. Their structures were elucidated by detailed NMR investigations and the relative configurations established by Difference NOE experiments. In addition, alloxanthoxyletin, nerolidol, epoxynerolidol, three known dihydrocinnamic acid derivatives and two amides were isolated. Detailed analysis of NMR data of Hortiolide A, whose structure was previosly established by X ray, are also provided

Aporfinoides en hojas de oxandra longipetala r. e. fr. (annonaceae).

The chemical study of the total alkaloids extract, realized for the classical method, of the Oxandra longipetala R. E. Fr., leaves, collected in the departamento de Córdoba, Colombia, permited the isolation and identification of oxoaporphine alkaloids lysicamine, O-methylmoschatoline, atherospermidine and liriodenine, together with the aporphines nornuciferine and anonaine. The structures were elucidated by spectroscopic methods (IR, 1H-NMR,13C-NMR, 2D experiments, mass spectrometry) and for comparisons with data from the literature.El estudio químico del extracto de alcaloides totales, realizado por el método clásico, de las hojas de Oxandra longipetala R. E. Fr., colectada en el departamento de Córdoba, Colombia, permitió el aislamiento e identificación de los alcaloides oxoaporfínicos lysicamina, O-metilmoschatolina, atherospermidina y liriodenina, junto con las aporfinas nornuciferina y anonaina. Las estructuras fueron elucidadas por métodos espectroscópicos (IR, RMN-1H, RMN-13C, experimentos 2D, espectrometría de masas) y por comparación con datos de la literatura