2,839 research outputs found
Cysteine starvation, isoleucyl-tRNAIle, and the regulation of the ilvGEDA operon of Escherichia coli.
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Effect of Combination Folic Acid, Vitamin B6 , and Vitamin B12 Supplementation on Fracture Risk in Women: A Randomized, Controlled Trial.
Epidemiologic studies have demonstrated an association of elevated plasma homocysteine levels with greater bone resorption and fracture risk. Vitamins B12 , B6 , and folic acid are cofactors in homocysteine metabolism, and supplementation with B vitamins is effective in lowering homocysteine levels in humans. However, randomized trials of supplemental B vitamins for reduction of fracture risk have been limited. Therefore, we performed an ancillary study to the Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS), a large randomized trial of women with preexisting cardiovascular disease or three or more coronary risk factors, to test whether a daily B vitamin intervention including folic acid (2.5 mg/day), vitamin B6 (50 mg/day), and vitamin B12 (1 mg/day) reduces nonspine fracture risk over 7.3 years of treatment and follow-up. Among 4810 women, we confirmed 349 nonspine fracture cases by centralized review of medical records. In a substudy of 300 women (150 in treatment group and 150 controls) with paired plasma samples at randomization and follow-up (7.3 years later), we measured two bone turnover markers, including C-terminal cross-linking telopeptide of type I collagen (CTX) and intact type I procollagen N-propeptide (P1NP). In Cox proportional hazards models based on intention-to-treat, we found no significant effects of B vitamin supplementation on nonspine fracture risk (relative hazard = 1.08; 95% confidence interval, 0.88 to 1.34). In a nested case-cohort analysis, there were no significant effects of B vitamins on fracture risk among women with elevated plasma homocysteine levels, or low levels of vitamins B12 or B6 , or folate at baseline. Furthermore, treatment with B vitamins had no effect on change in markers of bone turnover. We found no evidence that daily supplementation with B vitamins reduces fracture risk or rates of bone metabolism in middle-aged and older women at high risk of cardiovascular disease. © 2017 American Society for Bone and Mineral Research
Exact asymptotics of the freezing transition of a logarithmically correlated random energy model
We consider a logarithmically correlated random energy model, namely a model
for directed polymers on a Cayley tree, which was introduced by Derrida and
Spohn. We prove asymptotic properties of a generating function of the partition
function of the model by studying a discrete time analogy of the KPP-equation -
thus translating Bramson's work on the KPP-equation into a discrete time case.
We also discuss connections to extreme value statistics of a branching random
walk and a rescaled multiplicative cascade measure beyond the critical point
Assessment of Radiometer Calibration With GPS Radio Occultation for the MiRaTA CubeSat Mission
The microwave radiometer technology acceleration (MiRaTA) is a 3U CubeSat mission sponsored by the NASA Earth Science Technology Office. The science payload on MiRaTA consists of a triband microwave radiometer and global positioning system (GPS) radio occultation (GPSRO) sensor. The microwave radiometer takes measurements of all-weather temperature (V-band, 50-57 GHz), water vapor (G-band, 175-191 GHz), and cloud ice (G-band, 205 GHz) to provide observations used to improve weather forecasting. The Aerospace Corporation's GPSRO experiment, called the compact total electron content and atmospheric GPS sensor (CTAGS), measures profiles of temperature and pressure in the upper troposphere/lower stratosphere (~20 km) and electron density in the ionosphere (over 100 km). The MiRaTA mission will validate new technologies in both passive microwave radiometry and GPSRO: 1) new ultracompact and low-power technology for multichannel and multiband passive microwave radiometers, 2) the application of a commercial off-the-shelf GPS receiver and custom patch antenna array technology to obtain neutral atmospheric GPSRO retrieval from a nanosatellite, and 3) a new approach to space-borne microwave radiometer calibration using adjacent GPSRO measurements. In this paper, we focus on objective 3, developing operational models to meet a mission goal of 100 concurrent radiometer and GPSRO measurements, and estimating the temperature measurement precision for the CTAGS instrument based on thermal noise Based on an analysis of thermal noise of the CTAGS instrument, the expected temperature retrieval precision is between 0.17 and 1.4 K, which supports the improvement of radiometric calibration to 0.25 K
Arterial Pulse Wave Velocities are Unchanged Following 12 Weeks of Circuit Weight Training
Arterial stiffness is decreased after vigorous endurance training and increased after high-intensity resistance training. The effects of a combined program of moderate endurance and resistance exercise on arterial stiffness have not been determined. PURPOSE: To determine whether12 weeks of circuit weight training will decrease both central and peripheral arterial stiffness as estimated from pulse wave velocity (PWV). METHODS: Thirteen males and eight females (age 22 ± 2, height 162 ± 8 cm, weight 78 ± 20 kg) were assigned to control (n = 10) or exercise (n = 11) groups. Aerobic capacity and muscular strength were assessed before and at the end of the 12 week period. Arterial pressures and PWV (Doppler) were recorded every four weeks. Velocities from the carotid to femoral artery and from the femoral to dorsalis pedis artery were used as estimates of central and peripheral stiffness. RESULTS: Muscular strength increased by 26% (P = .001) and VO2 max increased by 17% (P = .06) following circuit training in the exercise group, but was unchanged for controls. Circuit weight training did not affect arterial pressures, (systolic = 117 ± 3, diastolic = 74 ± 3 mmHg; pooled across groups), or central and peripheral PWV (central PWV = 6.2 ± 0.6, peripheral PWV = 9.5 ± 0.7 m ∙ s-1; pooled across groups). CONCLUSIONS: In contrast to other reports of increases in arterial stiffness following high-intensity resistance training, increases in muscular strength following moderate-intensity exercise in the current study were not associated with increased arterial stiffness. Circuit training may be an appropriate exercise prescription to increase muscular strength for patients at risk for peripheral artery disease
Oxygen impurities in NiAl: Relaxation effects
We have used a full-potential linear muffin-tin orbital method to calculate
the effects of oxygen impurities on the electronic structure of NiAl. Using the
supercell method with a 16-atom supercell we have investigated the cases where
an oxygen atom is substitutionally placed at either a nickel or an aluminum
site. Full relaxation of the atoms within the supercell was allowed. We found
that oxygen prefers to occupy a nickel site over an aluminum site with a site
selection energy of 138 mRy (21,370 K). An oxygen atom placed at an aluminum
site is found to cause a substantial relaxation of its nickel neighbors away
from it. In contrast, this steric repulsion is hardly present when the oxygen
atom occupies the nickel site and is surrounded by aluminum neighbors. We
comment on the possible relation of this effect to the pesting degradation
phenomenon (essentially spontaneous disintegration in air) in nickel
aluminides.Comment: To appear in Phys. Rev. B (Aug. 15, 2001
Auger Recombination in Semiconductor Quantum Wells
The principal mechanisms of Auger recombination of nonequilibrium carriers in
semiconductor heterostructures with quantum wells are investigated. It is shown
for the first time that there exist three fundamentally different Auger
recombination mechanisms of (i) thresholdless, (ii) quasi-threshold, and (iii)
threshold types. The rate of the thresholdless Auger process depends on
temperature only slightly. The rate of the quasi-threshold Auger process
depends on temperature exponentially. However, its threshold energy essentially
varies with quantum well width and is close to zero for narrow quantum wells.
It is shown that the thresholdless and the quasi-threshold Auger processes
dominate in narrow quantum wells, while the threshold and the quasi-threshold
processes prevail in wide quantum wells. The limiting case of a
three-dimensional (3D)Auger process is reached for infinitely wide quantum
wells. The critical quantum well width is found at which the quasi-threshold
and threshold Auger processes merge into a single 3D Auger process. Also
studied is phonon-assisted Auger recombination in quantum wells. It is shown
that for narrow quantum wells the act of phonon emission becomes resonant,
which in turn increases substantially the coefficient of phonon-assisted Auger
recombination. Conditions are found under which the direct Auger process
dominates over the phonon-assisted Auger recombination at various temperatures
and quantum well widths.Comment: 38 pages, 7 figure
Uncovering functions of long-chain polyphosphate in higher eukaryotes: storage and synthesis of polyphosphate in matrix vesicles during mineralization
Poster: abstract no. 0052Conference Theme: The Extracellular Matrix NicheInorganic polyphosphate (polyP) is a fundamental molecule that occurs throughout life. PolyP has been found in mammalian tissues with particularly high levels of polyP in bone and cartilage, however its metabolism and functions remain poorly understood. Here, we initially demonstrate the highest concentrations of polyP yet observed in a higher eukaryote in matrix vesicles (MVs) secreted from mineralized osteoblasts. We also observed that MVs isolated from both osteoblasts and chondrocytes have a remarkable ability to synthesize very long-chain polyP under physiological condition. PolyP could be hydrolysed to Pi by one of the critical enzymes of mineralization, tissue non-specific alkaline phosphatase (TNAP). PolyP was consumed during mineralization induced by MVs. Extravesicular PolyP acted as an efficient inhibitor to suppress MV-induced HA formation. Biochemical properties of polyP synthesis were consistent with membrane-bound enzyme activity within the MV. Taken together, our work introduces a new fundamental macromolecule that could be a critical modulator of mineralization in the extracellular matrix.postprin
#Bieber + #Blast = #BieberBlast: Early Prediction of Popular Hashtag Compounds
Compounding of natural language units is a very common phenomena. In this
paper, we show, for the first time, that Twitter hashtags which, could be
considered as correlates of such linguistic units, undergo compounding. We
identify reasons for this compounding and propose a prediction model that can
identify with 77.07% accuracy if a pair of hashtags compounding in the near
future (i.e., 2 months after compounding) shall become popular. At longer times
T = 6, 10 months the accuracies are 77.52% and 79.13% respectively. This
technique has strong implications to trending hashtag recommendation since
newly formed hashtag compounds can be recommended early, even before the
compounding has taken place. Further, humans can predict compounds with an
overall accuracy of only 48.7% (treated as baseline). Notably, while humans can
discriminate the relatively easier cases, the automatic framework is successful
in classifying the relatively harder cases.Comment: 14 pages, 4 figures, 9 tables, published in CSCW (Computer-Supported
Cooperative Work and Social Computing) 2016. in Proceedings of 19th ACM
conference on Computer-Supported Cooperative Work and Social Computing (CSCW
2016
Asymptotic Normalization Coefficients for 13C+p->14N
The proton exchange reaction has been measured
at an incident energy of 162 MeV. Angular distributions were obtained for
proton transfer to the ground and low lying excited states in . Elastic
scattering of on also was measured out to the rainbow angle
region in order to find reliable optical model potentials. Asymptotic
normalization coefficients for the system have been
found for the ground state and the excited states at 2.313, 3.948, 5.106 and
5.834 MeV in . These asymptotic normalization coefficients will be used
in a determination of the S-factor for at solar
energies from a measurement of the proton transfer reaction
.Comment: 5 pages, 6 figure
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