On Modeling Clustering Indexes of BT-Like Systems

Abstract—In this paper, we explore the “clustering ” phenomenon in BT-like systems. A high clustering implies peers have a high tendency to exchange information with peers of the similar bandwidth type. We first show the clustering does exist in BT-like systems. Although high clustering is desirable for file sharing application, it may not be appropriate for multimedia streaming applications. We provide analytical models to calculate the clustering index and illustrate how one can control the clustering index for different P2P applications. I

FM mode-locked fiber optical parametric oscillator

An FM mode-locked fiber optical parametric oscillator is demonstrated. By introducing periodic phase perturbation in the cavity, 10-GHz pulse train can be obtained. The output signal has a side-mode suppression ratio of 55 dB. © 2011 OSA.published_or_final_versio

SELINDA: a secure, scalable and light-weight data collection protocol for smart grids

Security in the smart grid is a challenge as an increasing number of sensors and measurement devices are connected to the power grid. General purpose security protocols are not suitable for providing data security to devices with limited memory, computational power and network connectivity. In this paper, we develop a secure and light-weight scalable security protocol that allows a power system operator (PO) to collect data from measurement devices (MDs) using data collectors (DCs). The security protocol trades off between computations and device memory requirements and provides flexible association between DC and MDs. These features allow data to be securely transferred from MDs to PO via mobile or untrustworthy DCs. We analyze the complexity and security of the protocol and validate its performance using experiments. Our results confirm that our proposed protocol collects data in a secure, fast and efficient manner. © 2013 IEEE.published_or_final_versio

Walking in the Cloud: Parallel SimRank at Scale

Accepted Posterpublished_or_final_versio

A Neuroanatomical Signature for Schizophrenia Across Different Ethnic Groups

Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Resonance Imaging to investigate neuroanatomy in 126 patients with first episode schizophrenia who came from 4 ethnically distinct cohorts (White Caucasians, African-Caribbeans, Japanese, and Chinese). Each patient was individually matched with a healthy control of the same ethnicity, gender, and age (±1 year). We report a reduction in the gray matter volume of the right anterior insula in patients relative to controls (P < .05 corrected); this reduction was detected in all 4 ethnic groups despite differences in psychopathology, exposure to antipsychotic medication and image acquisition sequence. This finding provides evidence for a neuroanatomical signature of schizophrenia expressed above and beyond ethnic variations in incidence and clinical expression. In light of the existing literature, implicating the right anterior insula in bipolar disorder, depression, addiction, obsessive-compulsive disorder, and anxiety, we speculate that the neuroanatomical deficit reported here may represent a transdiagnostic feature of Axis I disorders

Novel application of magnetoresistive sensors for high-voltage transmission-line monitoring

High-voltage transmission lines are responsible for transmission of electric power. Their sag and electric current are important parameters for transmission-line monitoring. In this paper, a simple and promising method based on magnetoresistive sensors is proposed for transmission-line monitoring. This is a noncontact method and its installation is simple without the need for power cut. The method involves measuring emanated magnetic field from a line conductor at the ground level and, then, calculating the source position and current inversely. A proof-of-concept laboratory setup was constructed and a series of experiments were carried out for demonstration. This method can handle complicated transmission-line configuration by integrating the stochastic optimization approach into the inverse electromagnetic calculation. It was tested with the computational simulation of a 500 kV transmission-line configuration. The result shows the feasibility of using this transmission-line monitoring method in reality. © 2011 IEEE.published_or_final_versio

Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response

This study evaluated the preclinical activity and molecular predictors of response to gefitinib (Iressa®, Astra Zeneca Inc, UK) in nasopharyngeal carcinoma (NPC). The activity of gefitinib was evaluated in four human NPC cell lines-HK1, HONE-1, CNE2, C666-1. A representative gefitinib-sensitive (HK1, IC50 = 250 nM) and gefitinib-resistant cell line (HONE-1, IC 50 > 15 μM) were selected and compared for expression of epidermal growth factor receptor (EGFR) and related ligands, and activation of downstream proteins. Gefitinib induced G1 cycle arrest, apoptosis and inhibited cell invasion more significantly in HK1 than HONE-1 cells. HK1 expressed higher levels of p-EGFR, lower p-AKT and phospho-signal transducer and activator of transcription 3 (p-STAT3) than other cell lines. EGFR gene was found to be amplified in HK1. Gefitinib at IC50 concentrations significantly suppressed EGF-induced activation of p-EGFR, phospho-mitogen-activated protein kinase (p-MAPK) and p-STAT3, but p-AKT showed persistent activation in HK1 and HONE-1 cells. There was no difference in EGFR-ligand expression between the 4 NPC cell lines. In NPC samples derived from non-responders to gefitinib, 50% and 60% showed cytoplasmic and nuclear pi-EGFR expression, respectively, and 33% showed p-AKT expression. EGFR or KRAS mutations were not detected. This study suggests that most NPC cell lines are intrinsically resistant to gefitinib (except HK1 cells), and further studies are needed to confirm whether EGFR gene amplification and persistent AKT activation may influence response to gefitinib in NPC. © 2009 Springer Science+Business Media, LLC.published_or_final_versionSpringer Open Choice, 01 Dec 201

Generation of photovoltage in graphene on a femtosecond time scale through efficient carrier heating

Graphene is a promising material for ultrafast and broadband photodetection. Earlier studies addressed the general operation of graphene-based photo-thermoelectric devices, and the switching speed, which is limited by the charge carrier cooling time, on the order of picoseconds. However, the generation of the photovoltage could occur at a much faster time scale, as it is associated with the carrier heating time. Here, we measure the photovoltage generation time and find it to be faster than 50 femtoseconds. As a proof-of-principle application of this ultrafast photodetector, we use graphene to directly measure, electrically, the pulse duration of a sub-50 femtosecond laser pulse. The observation that carrier heating is ultrafast suggests that energy from absorbed photons can be efficiently transferred to carrier heat. To study this, we examine the spectral response and find a constant spectral responsivity between 500 and 1500 nm. This is consistent with efficient electron heating. These results are promising for ultrafast femtosecond and broadband photodetector applications.Comment: 6 pages, 4 figure

Tuning ultrafast electron thermalization pathways in a van der Waals heterostructure

Ultrafast electron thermalization - the process leading to Auger recombination, carrier multiplication via impact ionization and hot carrier luminescence - occurs when optically excited electrons in a material undergo rapid electron-electron scattering to redistribute excess energy and reach electronic thermal equilibrium. Due to extremely short time and length scales, the measurement and manipulation of electron thermalization in nanoscale devices remains challenging even with the most advanced ultrafast laser techniques. Here, we overcome this challenge by leveraging the atomic thinness of two-dimensional van der Waals (vdW) materials in order to introduce a highly tunable electron transfer pathway that directly competes with electron thermalization. We realize this scheme in a graphene-boron nitride-graphene (G-BN-G) vdW heterostructure, through which optically excited carriers are transported from one graphene layer to the other. By applying an interlayer bias voltage or varying the excitation photon energy, interlayer carrier transport can be controlled to occur faster or slower than the intralayer scattering events, thus effectively tuning the electron thermalization pathways in graphene. Our findings, which demonstrate a novel means to probe and directly modulate electron energy transport in nanoscale materials, represent an important step toward designing and implementing novel optoelectronic and energy-harvesting devices with tailored microscopic properties.Comment: Accepted to Nature Physic