Acute mountain sickness.

Acute mountain sickness (AMS) is a clinical syndrome occurring in otherwise healthy normal individuals who ascend rapidly to high altitude. Symptoms develop over a period ofa few hours or days. The usual symptoms include headache, anorexia, nausea, vomiting, lethargy, unsteadiness of gait, undue dyspnoea on moderate exertion and interrupted sleep. AMS is unrelated to physical fitness, sex or age except that young children over two years of age are unduly susceptible. One of the striking features ofAMS is the wide variation in individual susceptibility which is to some extent consistent. Some subjects never experience symptoms at any altitude while others have repeated attacks on ascending to quite modest altitudes. Rapid ascent to altitudes of 2500 to 3000m will produce symptoms in some subjects while after ascent over 23 days to 5000m most subjects will be affected, some to a marked degree. In general, the more rapid the ascent, the higher the altitude reached and the greater the physical exertion involved, the more severe AMS will be. Ifthe subjects stay at the altitude reached there is a tendency for acclimatization to occur and symptoms to remit over 1-7 days

Solution- and solid-phase synthesis of the polybasic lipid-modified C termini of Rho A and K-Ras 4B

Phasing the problem: Polybasic, farnesylated, and fluorescence- or biotin-tagged K-Ras 4B (1) and Rho A peptides can be efficiently synthesized in solution or on a solid support by employment of a combination of Fmoc and Aloc urethanes with trityl groups and a trityl linker. The synthesis methods described in both solid and solution phases present new opportunities for future investigation of areas such as membrane targeting by Ras, Rho, and related lipidated proteins. Biot = biotin, Aca = aminocaproic acid

Validation of enhanced kinect sensor based motion capturing for gait assessment

<div><p>Optical motion capturing systems are expensive and require substantial dedicated space to be set up. On the other hand, they provide unsurpassed accuracy and reliability. In many situations however flexibility is required and the motion capturing system can only temporarily be placed. The Microsoft Kinect v2 sensor is comparatively cheap and with respect to gait analysis promising results have been published. We here present a motion capturing system that is easy to set up, flexible with respect to the sensor locations and delivers high accuracy in gait parameters comparable to a gold standard motion capturing system (VICON). Further, we demonstrate that sensor setups which track the person only from one-side are less accurate and should be replaced by two-sided setups. With respect to commonly analyzed gait parameters, especially step width, our system shows higher agreement with the VICON system than previous reports.</p></div

Reconstruction of the body surface and averaged skeleton.

<p>(A, B) Three-dimensional reconstruction of the body surface and the corresponding skeleton reconstruction using two sensors. The surface was estimated based on the 3d point clouds using the marching cubes algorithm in MeshLab [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0175813#pone.0175813.ref032" target="_blank">32</a>]. Surface areas tracked by only one of the two sensors are highlighted in red (right) and blue (left). Corresponding Kinect skeleton joint positions estimates of the two sensors are shown as red and blue dots. The spatially averaged skeleton is indicated as black stick figure. (B) Magnification of the left lower leg. Notice, that the joint position estimates of the left sensor (blue) are closer to the surface which is only tracked by the left sensor (blue), correspondingly for the joint position estimates of the right sensor. (C) Averaged skeleton and joint position trajectories during walking obtained using six sensors.</p

Summary and agreement statistics for spatiotemporal gait parameters using Kinect tracking from both sides (two-sided).

<p>Summary and agreement statistics for spatiotemporal gait parameters using Kinect tracking from both sides (two-sided).</p