20 research outputs found
Distribution of sulfur in power supply lignite from North Hungary
Abstract
The present article discusses the results of measurements carried out to assess the distribution of different sulfur types in lignite samples deriving from two opencast lignite mines near the villages of Bükkábrány and Visonta. These mines ensure the continuous supply of fuel for one of Hungary's largest thermal power plant. According to our findings no significant differences could be identified between the samples of the two mines based on their total sulfur (St) content. Both lignite types were classified as coals with medium-sulfur content according to the system of Chou (1990). A majority of total sulfur is accumulated in lignite, while in the intercalated carbonaceous shale total sulfur is present in minor amounts. Usually the sequence of the distribution of sulfur among the different bond forms in lignite collected from opencast mine of Visonta is as follows: pyritic sulfur (Sp) > organic sulfur (Sorg) > sulfate sulfur (SSOorg4).
In the samples collected from Visonta and Bükkábrány quantities of total sulfur were similar. However, some difference in their distribution among various sulfur types were noted. Although half of the samples were weathered and the amount of pyrite sulfur must have been higher in the weathered lignite of Bükkábrány preceding the oxidation process, the sequence of the distribution of sulfur was likely as follows Sorg ≥ Sp ≥ SSO4
Corrigendum to "Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus". [Neuroscience 174 (2011) 50-63].
Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus.
UV light induced photodegradation of liposome encapsulated fluoroquinolones: An MS study
Fluoroquinolone antibacterial agents are among the drugsmost commonly causing phototoxic side effects.
The phototoxicity may be originated in formation of reactive oxygen species upon ultraviolet exposure.
Researches aiming the liposomal encapsulation of fluoroquinolones, expecting an increase in their therapeutic
index, enhance the importance of studies on physicochemical properties and photostability of
liposomal preparations. We studied the photodegradation of ciprofloxacin, ofloxacin and lomefloxacin
by mass spectrometry upon various doses of UV irradiation. Lomefloxacin, the most phototoxic fluoroquinolone
among them, was encapsulated into small unilamellar and multilamellar liposomes. Impact
of vesicle structure and lipid composition – the presence of unsaturated fatty acid containing dioleoylphosphatidylcholine
in dipalmitoyl-phosphatidylcholine liposomes – on the lomefloxacin photolysiswas
investigated; the structure of the main photoproducts was identified by mass spectrometry. It was found
that the presence and type of lipids influence the ways of photodegradation process
Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis
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Corrigendum to "Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus". [Neuroscience 174 (2011) 50-63].
Recommended from our members
Corrigendum to "Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus". [Neuroscience 174 (2011) 50-63].
Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus.
Clinical and experimental evidence demonstrates that endocannabinoids play either beneficial or adverse roles in many neurological and psychiatric disorders. Their medical significance may be best explained by the emerging concept that endocannabinoids are essential modulators of synaptic transmission throughout the central nervous system. However, the precise molecular architecture of the endocannabinoid signaling machinery in the human brain remains elusive. To address this issue, we investigated the synaptic distribution of metabolic enzymes for the most abundant endocannabinoid molecule, 2-arachidonoylglycerol (2-AG), in the postmortem human hippocampus. Immunostaining for diacylglycerol lipase-α (DGL-α), the main synthesizing enzyme of 2-AG, resulted in a laminar pattern corresponding to the termination zones of glutamatergic pathways. The highest density of DGL-α-immunostaining was observed in strata radiatum and oriens of the cornu ammonis and in the inner third of stratum moleculare of the dentate gyrus. At higher magnification, DGL-α-immunopositive puncta were distributed throughout the neuropil outlining the immunonegative main dendrites of pyramidal and granule cells. Electron microscopic analysis revealed that this pattern was due to the accumulation of DGL-α in dendritic spine heads. Similar DGL-α-immunostaining pattern was also found in hippocampi of wild-type, but not of DGL-α knockout mice. Using two independent antibodies developed against monoacylglycerol lipase (MGL), the predominant enzyme inactivating 2-AG, immunostaining also revealed a laminar and punctate staining pattern. However, as observed previously in rodent hippocampus, MGL was enriched in axon terminals instead of postsynaptic structures at the ultrastructural level. Taken together, these findings demonstrate the post- and presynaptic segregation of primary enzymes responsible for synthesis and elimination of 2-AG, respectively, in the human hippocampus. Thus, molecular architecture of the endocannabinoid signaling machinery supports retrograde regulation of synaptic activity, and its similar blueprint in rodents and humans further indicates that 2-AG's physiological role as a negative feed-back signal is an evolutionarily conserved feature of excitatory synapses