40 research outputs found
Decision to take osteoporosis medication in patients who have had a fracture and are 'high' risk for future fracture: A qualitative study
- Author
- A Cranney
- A Giorgi
- A Giorgi
- A Giorgi
- A Giorgi
- A Malpass
- AA Khan
- AJ Carr
- AM Gallagher
- BJ Edwards
- C Moustakas
- CG Unson
- D Bliuc
- D Weycker
- DE Polkinghorne
- Dorcas Beaton
- Earl Bogoch
- ER Bogoch
- ES Siris
- FJ Wertz
- Gillian Hawker
- J Dowell
- JEM Sale
- JM Morse
- Joanna EM Sale
- JP Brown
- JP McCormack
- JW Creswell
- K Siminoski
- Lucy Frankel
- M Melo
- MA Brookhart
- MA Jasper
- Monique A Gignac
- P Nolan
- P Pound
- RE Gearing
- S van Helden
- SD Berry
- SR Majumdar
- T Chevalley
- TW Weiss
- Victoria Elliot-Gibson
- World Health Organization
- World Health Organization Scientific Group
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
Abstract
Background
Patients' values and preferences are fundamental tenets of evidence-based practice, yet current osteoporosis (OP) clinical guidelines pay little attention to these issues in therapeutic decision making. This may be in part due to the fact that few studies have examined the factors that influence the initial decision to take OP medication. The purpose of our study was to examine patients' experiences with the decision to take OP medication after they sustained a fracture.
Methods
A phenomenological qualitative study was conducted with outpatients identified in a university teaching hospital fracture clinic OP program. Individuals aged 65+ who had sustained a fragility fracture within 5 years, were 'high risk' for future fracture, and were prescribed OP medication were eligible. Analysis of interview data was guided by Giorgi's methodology.
Results
21 patients (6 males, 15 females) aged 65-88 years participated. All participants had low bone mass; 9 had OP. Fourteen patients were taking a bisphosphonate while 7 patients were taking no OP medications. For 12 participants, the decision to take OP medication occurred at the time of prescription and involved minimal contemplation (10/12 were on medication). These patients made their decision because they liked/trusted their health care provider. However, 4/10 participants in this group indicated their OP medication-taking status might change. For the remaining 9 patients, the decision was more difficult (4/9 were on medication). These patients were unconvinced by their health care provider, engaged in risk-benefit analyses using other information sources, and were concerned about side effects; 7/9 patients indicated that their OP medication-taking status might change at a later date.
Conclusions
Almost half of our older patients who had sustained a fracture found the decision to take OP medication a difficult one. In general, the decision was not considered permanent. Health care providers should be aware of their potential role in patients' decisions and monitor patients' decisions over time
3D modelling of the flow of self-compacting concrete with or without steel fibres. Part I: slump flow test
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 04/04/2014
- Field of study
In part I of this two-part paper, a three-dimensional Lagrangian smooth particle hydrodynamics method has been used to model the flow of self-compacting concrete (SCC) with or without short steel fibres in the slump cone test. The constitutive behaviour of this non-Newtonian viscous fluid is described by a Bingham-type model. The 3D simulation of SCC without fibres is focused on the distribution of large aggregates (larger than or equal to 8 mm) during the flow. The simulation of self-compacting high- and ultra-high- performance concrete containing short steel fibres is focused on the distribution of fibres and their orientation during the flow. The simulation results show that the fibres and/or heavier aggregates do not precipitate but remain homogeneously distributed in the mix throughout the flow
Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells
- Author
- A Hossain
- A Lujambio
- A Michael
- A Varis
- A Zernecke
- AB Hui
- AB Hui
- AE Williams
- AM Booth
- AM Cheng
- AT Go
- B Fevrier
- BR Wilfred
- C Admyre
- C Blenkiron
- C Camps
- C Tomasetto
- CH Lawrie
- CH Lin
- CM Heaphy
- CP Bracken
- CP Paweletz
- D Cifuentes
- D Duelli
- David Danforth
- DB Jackson
- DD Taylor
- DJ Gibbings
- DJ Luciano
- DM Duelli
- DM Duelli
- DM Duelli
- DM Pegtel
- DN Danforth Jr
- Dominik M. Duelli
- Dong-Ja Kim
- DR Cochrane
- E Bandres
- EH Mahlamaki
- F Yu
- G Rabinowits
- G Raposo
- Gordon Langsley
- H Gal
- H Valadi
- H Yamada
- HJ Peltier
- HM Heneghan
- HM Heneghan
- I Bussing
- I Ibarra
- J Debnath
- J Godlewski
- J Ratajczak
- J Skog
- JE Lang
- JJ Zhao
- JT Loud
- K Ohgaki
- KH Lee
- L Ma
- LB Frankel
- LF Sempere
- Lucy Pigati
- LV Coren
- Michelle L. Hastings
- MJ Lodes
- ML Si
- MP Hunter
- MV Iorio
- MV Iorio
- N Kosaka
- N Kosaka
- NC Lau
- O Kovalchuk
- PA Davoren
- PA Gregory
- PS Mitchell
- Q Huang
- R Garzon
- RA Mathias
- Ravi Iyengar
- RM Johnstone
- RS Dua
- S Cikos
- S Qian
- S Staubach
- S Tsuchiya
- S Valastyan
- S Zhu
- SA Helvik
- SA Khan
- SF Tavazoie
- SJ Gould
- SM Park
- Sree C. S. Yaddanapudi
- SS Chim
- Steven A. Hearn
- T Hata
- T Itoh
- TD Schmittgen
- TE Miller
- TS Chen
- U Welsch
- W Liu
- W Yang
- W Zhu
- X Chen
- X Yu
- Y Kawahara
- Y Shimono
- YS Lee
- YS Lee
- Z Huang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
MicroRNAs (miRNAs) in body fluids are candidate diagnostics for a variety of conditions and diseases, including breast cancer. One premise for using extracellular miRNAs to diagnose disease is the notion that the abundance of the miRNAs in body fluids reflects their abundance in the abnormal cells causing the disease. As a result, the search for such diagnostics in body fluids has focused on miRNAs that are abundant in the cells of origin. Here we report that released miRNAs do not necessarily reflect the abundance of miRNA in the cell of origin. We find that release of miRNAs from cells into blood, milk and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. In particular, the bulk of miR-451 and miR-1246 produced by malignant mammary epithelial cells was released, but the majority of these miRNAs produced by non-malignant mammary epithelial cells was retained. Our findings suggest the existence of a cellular selection mechanism for miRNA release and indicate that the extracellular and cellular miRNA profiles differ. This selective release of miRNAs is an important consideration for the identification of circulating miRNAs as biomarkers of disease
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- Brüls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
- Cardenas Faviola
- Cardenas Lolo
- Cardenas Veronica
- Carder Carol
- Carder Paul
- Carpenter Kelly
- Carrano Anthony V.
- Carriere Jason
- Carter Jason
- Carter Kelvin
- Carter Nigel
- Caruso Lauren
- Casias Kristal
- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
- Chalk Shani
- Challacombe Jean F.
- Chan Ka
- Chan Sheryl N.
- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
- Chen Baoxian
- Chen Bin
- Chen Chira
- Chen Chong
- Chen Chong
- Chen Chun-Nan
- Chen Cong
- Chen Ellson
- Chen Hsiu-Chuan
- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
- Clack Rob
- Clamp Michele
- Clark Anthea
- Clark Graham
- Clark Kevin
- Clark Lynn
- Clark Lynn M.
- Clark Richard
- Clark Sarah
- Clark Sue
- Clarke Adrian
- Clarke Betty
- Clarke Eddie
- Clarke Kay
- Clarke Laura
- Clawson Hiram
- Clee Chris
- Clegg Shelia
- Clerc Blankenburg Kerstin Petra
- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
- Cockrell Raynard
- Coffey Alison
- Cofield Jackie
- Coggill Penelope
- Cohn Judith D.
- Colayco Rick
- Cole Lotte
- Collier Rachael
- Collings Simon
- Collins Francis S.
- Collins John
- Collins Philip
- Collymore Al
- Colman Louise
- Combs Jessie
- Comstock Robin
- Cong Bin
- Conner Richard
- Connolly Anthony
- Connolly Karen
- Conquer Jennie
- Conrad Ansgar
- Conroy Donald
- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
- Cooke Patrick
- Cooper Jonathan
- Cooper Rachel
- Cooper Robert
- Copeland Alex
- Coppola Maria
- Copsey Teresa
- Corby Nicole
- Cordes Matt
- Cordray Rebecca
- Cornell Christine
- Cornell Earl
- Cornell Linda
- Cornell Ruth
- Corum Ben
- Cottage Amanda
- Cotton Sara
- Coulson Alan
- Couronne Olivier
- Courtney Laura P.
- Coville Gez
- Cox Anthony
- Cox Caroline D.
- Cox Tony
- Coxhill Robert
- Coyle Marcus D.
- Craig Matthew
- Crane Tom
- Crawford Amanda L.
- Crawley Matt
- Cree Andrew
- Crespeau Hervé
- Crew Victor
- Critchlow Terrance
- Critz Paul
- Cruaud Corinne
- Cuff James
- Cui Hongjuan
- Cui Jinhui
- Cui Peng
- Cui Peng
- Culley Karl
- Cummings Auli
- Cummings Kirsti
- Cummings Paul
- Cummings Stephanie
- Cuomo Christina A.
- Curran Adam
- Curwen Valery
- Cutts Jeffrey
- Czubayko Martin
- D\u27Souza Lisa Marie
- Da Silva Corinne
- Dai Li
- Dalin Eillen
- Dang Michelle
- Danganan Linda
- Daniels Rachael
- Dathorne Stephanie R.
- Daum Christopher
- David Robert
- Davidson Lucy
- Davidson Stuart
- Davies Jonathon
- Davies Joy
- Davies Nicholas
- Davies Robert
- Davila Mary Louise
- Davis Candi Mon\u27et
- Davis Cheryl
- Davis Clay
- Davis Jayne
- Davis John
- Davis Matthew
- Davy-Carroll Latarsha
- Dawoe Tenzin
- Dawson Elisabeth
- De Anda Claudia
- De Latorre Andrea
- Deadman Rebecca
- Dean Peter
- Dear Simon
- Dearden Frances
- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
- DeGray Stewart
- Degusta David
- Deguzman Maria
- Dehal Paramvir
- Delgado Marcos
- Delgado Oliver
- Delhaunty Kimberley
- Deloukas Panos
- Deng Yajun
- Dennis Janet
- Denson Shawn
- Denys Mirian
- Deramo Christine
- Desai Anu
- Detter John C.
- Devlin Laurie
- Dewar Ken
- Dhami Pawandeep
- Dhongsar Chemey
- Dias Jennifer
- Dias Victoria
- Dibartolo Genevieve
- Dibling Catherine
- Dickson Mark
- Diekhans Mark
- Dietz-Band Jeanne
- Digennaro Richard
- Dilts Karen
- Dimitrijevic-Bussod Mira
- Ding Hao
- Ding Keyue
- Ding Li
- Ding Yan
- Dinh Huyen H.
- Dixon Kami
- Do Long
- Dobbs Ruth
- Dobson Richard
- Dockree Catherine
- Doddington Daniel
- Dodsworth Steven
- Doggett Norman
- Doggett Norman A.
- Dong Hui
- Dong Kimberly
- Dong Wei
- Dong Wei
- Dong Xiaojia
- Donlin Jeremy E.
- Dooley Kathy
- Dooling David
- Dorje Passang
- Dorjee Kunsang
- Dorris Lester
- Dorsett Victor
- Doucette-Stamm Lynn
- Douthwaite Karen J.
- Down Thomas
- Draper Heather
- Du Feiyu
- Du Hui
- Du Yutao
- Duarte Suzanne
- Dubchak Inna
- Duffy Noah
- Dugan-Rocha Shannon
- Dunham Andrew
- Dunham Ian
- Dunn Adam M.
- Dunn Anne
- Dunn Matthew
- Dunwell Erin
- Dupes Alan
- Durbin Kenneth J.
- Durbin Richard
- Durham Jillian
- Dutta Ireena
- Dwyer Ruth
- Dyer Lauren
- Dziuda Darius
- Earnhardt Christopher D.
- Earthrowl Mark
- Eastham Emma
- Eastham Timothy
- Eaves Kristy A.
- Eckenberg Ralph
- Edgar Darren
- Edionwe Susan Omwanghe Osayanro
- Edwards Carol
- Edwards Jennifer
- Edwards Karen
- Egan Amy
- Eichler Evan
- Eichler Evan
- Ejima Fumio
- Elkin Chris
- Ellington Andrew
- Elliot David
- Elliot Glendoria
- Elliot Jeffrey
- Ellwood Matthew
- Emberson Becky
- Emelianenko Natalia
- Emery-Cohen Alexandra J.
- Endrizzi Matthew
- Engh Ger van den
- Engle David
- Erickson Jeffery
- Erler Anne Marie
- Errington Helen
- Escobar Julio
- Escotto Michael
- Eugene Craig S.
- Evans Gareth
- Evans John
- Evans Katie
- Evans Richard
- Eveleth Gerald
- Eyras Eduardo
- Fan Hongyuan
- Fan Keke
- Fang Jianqiu
- Farina Abderrahim
- Faro Susan
- Faulkner Louisa
- Fawcett Joseph J.
- Fechtel Kim
- Fellingham Charlotte
- Felming Claire
- Felsenfeld Adam
- Feltwell Theresa
- Feng Guodong
- Feng Haiyan
- Feng Jie
- Feng Xiaoli
- Fennell Stephen
- Ferguson Alicia
- Fernandez Sonia
- Fernandez-Suarez Xose
- Fernando Pushpa Ranjani
- Ferriera Pat
- Fertitta Anne
- Fey Jim
- Fidel Patrick
- Fields Elizabeth
- Fink Marie
- Finley Maria C.
- Finn Robert
- Fischer Heather
- Fischer Laurice
- Fisher Shelia
- Fitch Pat
- Fitzgerald Mike
- Flack Tina
- Flagg Nicole
- Flanagan J.
- Fleming Kerry
- Flint Jonathan
- Flint Mark
- Flowers Dave
- Floyd Yvonne
- Foley Karen
- Folta Peg
- Fong Jonathan
- Fonknechten Núrua
- Footman Simon
- Forbes Lisa D.
- Ford Amanda F.
- Foster Myre J.
- Fotopulos Dea
- Fourcade Matthew
- Fowler John
- Fox Jessica
- Frame Deborah
- Francis Matthew
- Francis Stephen
- Frankel Ken
- Frankish Adam
- Frankland John
- Fraser Audrey
- Fraser David
- Frazier Marvin
- French Lisa
- Fricker David
- Fridlyand Jane
- Fronick Catrina
- Frost Carole
- Frost Daniel
- Frost Jackie
- Frost Lorna
- Fu Gang
- Fu Gang
- Fu Gang
- Fu Qiushi
- Fujioka Michiru
- Fujiyama Asao
- Fukawa Rintaro
- Fuller Liam
- Fuller Sharin
- Fullerton Kathryn
- Fulton Lucinda A.
- Fulton Robert S.
- Furey Terrence S.
- Furuhashi Mie
- Förste Silke
- Gabisi Abdul M.
- Gage Diane
- Gaige Tony
- Galgoczy Petra
- Gallegos Celsa
- Galvez Michael
- Gammon Stuart
- Gao Anwu
- Gao Jimei
- Gao Quan
- Gao Yang
- Gao Yimei
- Garcia Carmen
- Garcia Emilio
- Garcia Marvin
- Garcia Ricardo M, III
- Garcia-Martinez Antonio
- Gardner Alison
- Gardner Alison
- Garduno Consuelo
- Gardyna Steph
- Garner Patrick
- Garner Toni T.
- Garnes Jeffrey A.
- Garnett Jane
- Garza Melissa
- Gatewood Joseph M.
- Gatland Leigh
- Gatland Lindsay
- Gattung Stacie
- Gay Laura
- Gearin Gary
- Gebreyesus Binyam
- Gelein Cynthia
- Gelpke Maartin
- Gench Stephanie L.
- Geng Jianing
- Georgescu Anca
- Geotina Amy
- Ghori Jilur
- Ghose Sayantan
- Gibbs Ben
- Gibbs Richard A.
- Gibson Diane
- Gibson Elizabeth
- Gifford Mary
- Gil Isaias
- Gilbert James
- Gilby Lisa
- Gill Rachel
- Gillet Will
- Gillson Christopher
- Gilna Paul
- Gimmel Verena
- Gingrich Jeff
- Giovanelli Kira
- Glavina Tijana
- Glithero Rebecca
- Glöckner Gernot
- Gnerre Sante
- Gnirke Andreas
- Gold Darren
- Golinveaux Kristen
- Gomez Maria
- Gong Guanghui
- Gong Jinying
- Gonzales Eidelyn
- Gonzalez Guillermo B.
- Gooderham April
- Goodstadt Leo
- Goodstein David
- Goodwin Lynne A.
- Gordon Catherine
- Gordon Laurie A.
- Gordon Seth
- Gorton Matthew
- Gorvad Ann
- Gould Christine
- Goyea Ernest
- Goyette Audra
- Grady Deborah I.
- Grady Michelle L.
- Grafham Darren
- Graham Joe
- Grandbois Edward
- Grant Jennifer
- Grant Michael
- Grant Susan
- Graves Tina A.
- Gray Bruce
- Gray Emma
- Gray Lain
- Green Lisa
- Greenhalgh James
- Greenhill Joe
- Gregg Philippa
- Gregory Simon
- Grewal Nennu
- Gribble Susan
- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
- Grocock Russell
- Groza Matthew
- Gu Jingli
- Gu Jun
- Gu Jun
- Gu Wenyi
- Gu Wenyi
- Gu Xiaochang
- Guan Qiaoning
- Guarin Hannibal
- Guel Metzalli
- Guerra William
- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
- Guo Daorong
- Guo Jane
- Guo Lili
- Gustafson Erik
- Guthrie Ian
- Guyer Mark
- Gwilliam Rhian
- Gyaltsen Kunsang
- Gyapay Gábor
- Görlich Yvonne
- Ha Chi
- Hafez Nabil
- Haglund Krista
- Hagopian Daniel
- Hagos Birhane
- Haim Allen
- Hajek Patrick
- Hall Brett Lynn
- Hall Brittany
- Hall Jennifer
- Hall Rebekah
- Hall-Tamly Gretta
- Halls Karen
- Hallsworth-Pepin Kym
- Hamada Junko
- Hamilton Cerissa
- Hamilton Keelan A.
- Hamilton Matt
- Hamlett John
- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
- Harper David
- Harper Georgina
- Harper Patrik
- Harradence Grant
- Harris Anthony
- Harrison Charlene-Lou
- Harrison Elliot
- Harrison Ruth
- Hart Elizabeth
- Hasegawa Tomoko
- Hashimoto Etsuko
- Hashimoto Wakako
- Hassan Daniel
- Hatcher Beath
- Hattori Masahira
- Haugen Eric
- Haussler David
- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
- Hawkins Trevor
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- Haydu Lauren
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- He Fengying
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- Heilig Roland
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- Heinze Ivonne
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- Hellsten Uffe
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- Henning Karla
- Hepa Victor
- Herd Tim
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- Hernandez Judith
- Hernandez Omar
- Herseim Allyson
- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
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- Holloway Ele
- Holmes Andrea
- Holmes Ian
- Holmes Sarah
- Holroyd Simon
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- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
- Honan Tracy
- Hood Leroy
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- Howden Philip
- Howe Kevin
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- Hupman Matt
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- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
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- Imo Kelvin C.
- Inacio Nicole
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- Ince Michael
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- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
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- Jackson Terri
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- Kettleborough Ross
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- Kong Yi
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- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
- Krogh Anders
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- Kruchowski Scott S.
- Kube Michael
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- Lander Eric S.
- Landers Tom
- Langford Cordelia
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- Lewis Doreen
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- Lindblad-Toh Kerstin
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- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
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- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
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- Lu Yongxiang
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- Lucas Robert
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- Lucier Raymond L.
- Ludeman Thom
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- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
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- Manohar Chitra
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- Mareth David
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- Marquis-Homeyer Catherine
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- Marra Marco
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- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
- McPherson John D.
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- Meidi Patrick
- Meier Elke
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- Menuge Noel
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- Mercado Iracema C.
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- Mesirov Jill P.
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- Mungall Andy
- Munidasa Mala
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- Murayama Yuji
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- Nagamine Kentaro
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- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
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- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
- Naylor Jerome
- Nazareth Lynne V.
- Neal Dearl D.
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- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
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- O\u27Loughlin Jennifer
- O\u27Neill Keith
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- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
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- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
- Oliver Karen
- Olsen Anne S.
- Olson Maynard V.
- Omotosho Bamidele
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- Ow David
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- Pasternak Shiran
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- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
- Paulson Edward
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- Pearce Alexandra
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- Peng Ze
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- Pennacchio Len A.
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- Percy Chantel
- Perez Agapito
- Perez Lesette M.
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- Ridler Kerry
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- Rise Cecil
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- Robinson Melanie
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- Rong Li
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- Sasaki Takashi
- Satpathy Suraj
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- Saurin William
- Savery Glenford G.
- Sawada Nori
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- Saxman Eric
- Scarpelli Claude
- Scharfe Maren
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- Smink Luc
- Smith Andrew
- Smith Andrew
- Smith Cherylyn
- Smith Doug
- Smith Douglas R.
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- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
- Sotheran Elizabeth
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- Spencer Brian
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- Stallings Raymond I.
- Stalvey Malinda
- Stamford Steve
- Stammers Melanie
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- Stege Justin T.
- Steingruber Helen
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- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
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- Trejos Zulma Y.
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- Un Chun
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- Wang Ying
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- Watanabe Saki
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- Wickremasinghe Manosha I.
- Widaa Sara
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- Williamson Helen
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- Wong Benjamin
- Wong Gane K-S
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- Wooden Steven H.
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- Woodmansey Rebecca
- Woods Eric
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- Worley Kim Carlyle
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- Wray Paul
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- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
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- Wu Jung-Rung
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- Wycoff-Montenegro Melissa
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- Xi Yingying
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- Xu Jing
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- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
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- Yao Zhijian
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- Ye Chen
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- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
- Bindt Felix
- Blas Karla Soto
- Bo Tang
- Boada Yadira
- Boer Meine
- Bohner Ariel
- Borovko Irina
- Bott Amie
- Bouwmeester Susan
- Bowman Kyle
- Boxem Mike
- Boxuan Cheng
- Boyce Kira
- Boyer Jess
- Brasas Valentas
- Brewer Mathew
- Briand William
- Brink Matilda
- Browne Emily
- Buckley-Taylor Russell
- Budhan Stephanie
- Buller Lisa
- Burckhardt Nele
- Burgland Zachary
- Burns Frank
- Burridge Matt
- Burud Hanna Nedreberg
- Buson Felipe Xavier
- Butterfield Tom
- Byagathvalli Gaurav
- Byatt Gabriel
- Byun Sumin
- Caballero Amalia
- Cai Fu
- Cai Niangui
- Caldwell Sarah
- Camacho Yazmin
- Camille Monteil
- Campbell Robert
- Cao Qinhao
- Cao Yixin
- Cao Yuze
- Carrillo Leo
- Carter Jonah
- Casas Alexis
- Castillo Nora Esther Torres
- Castillo Sandra
- Cave John
- Chai Ruochen
- Chamiec-Case Elizabeth
- Chan Janice
- Chan Yuan-Yao
- Chandramouli Priyanka
- Chang Annabel
- Chang Catherine
- Chang Kevin
- Chang Thomas
- Chang Ting-Chen
- Chang Yu-Ci
- Chapman Tyler
- Chater Dounia
- Chau Anthony
- Chavez Benjamin
- Chavez Francisco
- Chehade Ibrahim
- Chen Carmen
- Chen Chih-Chiang
- Chen Ching-Wei
- Chen Janice
- Chen Junhong
- Chen Junyang
- Chen Junyu
- Chen Pei-Hong
- Chen Ryan
- Chen Weixuan
- Chen Yan
- Chen Yi-Cian
- Chen Yifei
- Chen Zhuoyang
- Cheng Cheng
- Cheng Haolun
- Cheng Hsuan
- Cheng Yu-Hong
- Cheng Yu-Hsuan
- Chenxi Liang
- Cherupalla Arjun
- Chi Jordi
- Chi Shumei
- Chiang Jason
- Chiang Woody
- Ching Lai Tsz
- Ching Lam Kai
- Ching Law Hiu
- Ching Luk Hau
- Chinnathambi Sathivel
- Cho Sungwoo
- Choi Lee Sze
- Choi Youngeun
- Chou Ryan
- Chou Ryan
- Chu Wai Yan
- Chua Yah Tse Sabrina
- Chuang Yi-Chien
- Chulkova Nadezhda
- Chun Cheung Man
- Chun Emily
- Chun Ng Tsz
- Cifuentes Rodrigo Hernandez
- Clapper Jude
- Clapper Jude
- Clark Brittany
- Clemente Borja Sanchez
- Clerc Valerian
- Clodomir Christina
- Coates Ryan
- Cohen Katherine
- Colant Noelle
- Coleman Sarah
- Colgan Cian
- Cone Eli
- Corre Christophe
- Costa Ben
- Cott Rachel Van
- Craw Darilyn
- Crispim Larissa de Souza
- Crone Michael Andrew
- Crooijmans Marjolein
- Crosby Laurel Constanti
- Crowley Peter
- Cruz Frida
- Cubukcu Hande
- Culfogienis Dylan
- Czekster Clarissa
- Dai Leijie
- Dalangin Rochelin
- Daniel Benjamin
- Daniels Lea
- Das Neves Laura
- Das Diptatanu
- Davis Christina
- De Silva Nimaya
- Deb Shalini S.
- Deepak Kumar S.
- Deibel Emilie
- Dejoie Julianne
- Dejoux Alice
- DeKloe Jackson
- Del Toro Mariano
- Delalez Nicolas
- Delgadillo Sabrina
- Delhomme Jean
- Demchuk Aubrey
- Deng Nian Ruei
- Deng Rui
- Denter Jennifer
- Deshmukh-Reeves Ed
- Despres Philippe C.
- Devi Velvizhi
- Dhaliwal Gurpreet
- Diaz Fernanda
- Ding Shizhi
- Ding Yiming
- Ding Zhipeng
- Dingyue Tang
- Dirven Yvette
- Dissmann Jil-Sophie
- Do Stephanie
- Dogra Arushi
- Dominguez Viana Isabel Perez
- Dong Dongyang
- Dong Haitao
- Dong Jason
- Dong Shan
- Dong Shan
- Dong Shan
- Dong Shangzhi
- Dong Shangzhi
- Doyle David
- Doyle Shannon
- Dube Alexandre
- Dubuc Emilien
- Dunstan Izzy
- Dusseaux Theodore A.
- Dvorkin Steve
- Edelmayer Marco
- Ehrenworth Amy
- Eidloth Franziska
- Eijkens Bruno
- Eilers Keno
- El Moubayed Yorgo
- Elcin Evrim
- Elias Noel
- Elikan Max
- Ellermeier Craig
- Elliott Hannah
- Elsa Yeung Hoi Lam
- Emilov Kristian
- Espinoza Diego
- Evans Rhys
- Faidh Mohammed
- Falgenhauer Elisabeth
- Fan Catherine
- Fang Chengzhu
- Fang Choco
- Fang Xiangyi
- Farhi Einan
- Farias Sebastian
- Farny Natalie
- Farny Natalie G.
- Farrell Jennifer
- Fassler Jan
- Faurdal David
- Faustova Ilona
- Feng Xinhua
- Fernandez Cesar Ibrahym Rodriguez
- Fierro Daniela Olono
- Figueroa Ana Cristina
- Figueroa Jose Arnulfo Juarez
- Fikry Clara
- Filzen Rachael
- Fischer Matthew
- Fitzgerald Kevin
- Fitzgerald Liza
- Flores Vinicius
- Foda Asmaa
- Fong Yuhui Deborah
- Forman Victor
- Frank Stefanie
- Frankel Eva
- Freire Paulo J. C.
- Friedman Yonatan
- Frohlich Lisa
- Fu Wenhan
- Fu Yousi
- Fuentes Ernie
- Fulton Leah
- Fung Ip Ning
- Fung Yam Shing
- Gabrielli Jacopo
- Gahagan Maddison
- Gaitt Tobias
- Gaizauskaite Aukse
- Gallegos Isabella
- Gamoneda Diego
- Gandhi Rishi
- Gao Cecily
- Garavito Paula
- Garcia Chrismar
- Garcia David
- Garrido Delia
- Garulli Elisa
- Gaspar Camila
- Gaudi Alex
- Ge Gao
- Ge Yubin
- George Stephan
- Gerard Antoine
- Gershater Markus
- Ghosh Souvik
- Giannopoulos Alexandros Dimitriou
- Giannoula Yvoni
- Gilman Daniel Barber James
- Glockner Eleanor
- Goenka Anushya
- Goetz Marley
- Gogineni Namrata
- Gokul [NO FIRST NAME IN SCOPUS]
- Gonzalo Gonzalo Saiz
- Goodson Michael
- Gopaul Deshmukh
- Gou Yanchen
- Govers Jolijn
- Graaf Floor de
- Grace Tsui Shing Yan
- Graves Daniel
- Grazulyte Inga
- Greenwald Matthew
- Gu Jiajun
- Gu Yiheng
- Gu Yining
- Guadagnino Brett
- Guenther James
- Guerassimoff Lea
- Guo Jintao
- Gupta Shreya
- Guptil Chris
- Guseva Anna
- Ha Jacqueline
- Haddock-Angelli Traci
- Haight Travis
- Hale Mitch
- Hamady Carla
- Han Wang
- Han Weitang
- Handal Paola
- Hanrong Zhu
- Hansen Cecilie
- Hao Junyao
- Hao Mei
- Hao Zhengguo
- Haoran Xu
- Haralsvik Anne Kristin
- Hariyani Imtiyaz
- Hartley Zach
- Hassan Sondoss
- Hau Sion
- He Fa
- He Hanker
- He Henry
- He Karen
- He Lindong
- He Menglan
- He Peixiang
- He Yuna
- He Zhien
- Healy Liam
- Heath Emily
- Heger Theresa
- Hei Chan Yick
- Heijningen Franca van
- Heintze Maxime
- Hemmings Sam
- Heng Heng
- Heng Mary
- Henras Anthony
- Herbert Heydy
- Hernandez Ivan Martin
- Hernandez Laura Armero
- Herrmann Max
- Heux Stephanie
- Hewitt Amy
- Hiesinger Marlene
- Hill Kurt
- Hin Chan Lok
- Hin Wong Chung
- Hin Yu Man
- Ho Anthony
- Ho Ng Sze
- Ho Tim
- Hodson Sophie
- Hofer Sebastian
- Holman Olivor
- Holmedal Ingebjorg
- Hong Lai Tsz
- Hong Lee Chi
- Hong Yiquan
- Hong Yirui
- Horz Philip
- Hoskan Mehmet Ali
- Hosseini Reza
- Hou Ali
- Houmani Moustafa
- Hsiao Chia-Yi
- Hsieh Yi Da
- Hsu Chia-Wei
- Hsu Yi-Hsuan
- Hu Miao
- Hu Shi
- Hu Vivian
- Hu Wenyue
- Hu Xinyi
- Hu Yunyun
- Hu Zhaoqing
- Hu Zhiyuan
- Huang Fangliang
- Huang Jiaxi
- Huang Morris
- Huang Ray
- Huang William
- Huang Yansong
- Huang Yaohua
- Huang Yilin
- Huang Yinpin
- Huanying He
- HuaYue Zhang
- Huerta Ana Laura Torres
- Humphreys Christopher
- Hung Chia
- Husnatter Kai
- Huuki Liz
- Huynh Juilanne
- Hwang Michael
- Ibrahim Ahmed
- Ikagawa Yuichiro
- Ikhsan Muhammad
- Ikwuagwu Bon
- Imgold Markus
- Inanc Tugba
- Inckemann Rene
- Isaac Ashley
- Isaacs Farren
- Isogai Tatsuki
- Iwuogo Amanda
- Iyer Aditya
- Iyer Tvarita Shivakumar
- Izzati Nurul
- Jacq Annick
- Jain Rishabh
- Jain Shubham
- Jainarayanan Ashwin Kumar
- Jakutis Gabrielius
- Jaoui Samuel
- Japranata Valdi Ven
- Jaramillo Alfonso
- Jasiunas Simas
- Jasti Naveen
- Jay Leung Chung Yin
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- Zhaoting Li
- Zhecheng Huang
- Zheng Daniel
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- Zhong Yanling
- Zhou Hanmi
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- Zhou Jianan
- Zhou Rui
- Zhou Shuyao
- Zhou Xuanhao
- Zhou Yanjun
- Zhou Yi
- Zhou Yinchi
- Zhou Yineng
- Zhou Yuezhang
- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
- Allan L
- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
- Amoils S.
- Anderson David
- Antoniades C
- Arbane Gill
- Arias Ava Maria
- Armour C.
- Armstrong Lisa
- Armstrong Natalie
- Arnold David
- Arnold H
- Ashish A
- Ashworth Andrew
- Ashworth M
- Aslani S
- Assefa-Kebede Hosanna
- Atkin C
- Atkin Paul
- Aul Raminder
- Aung H
- Austin Liam
- Avram Cristina
- Ayoub A.
- Babores M.
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie J.K.
- Bain S
- Bakali M
- Bakau M
- Baldry E
- Baldwin D
- Baldwin M
- Ballard C
- Bandula Steven
- Banerjee A
- Bang Dongchun
- Barker R E
- Barman L
- Barratt Shaney
- Barrett Fiona
- Basire Donna
- Basu N.
- Bates A
- Bates M
- Batterham R
- Baxendale H
- Bayes Hannah
- Beadsworth M.
- Beckett P
- Beggs Mark
- Begum M
- Beirne Paul
- Bell Murdina
- Bell R
- Bennett Kaytie
- Beranova Eva
- Bermperi Areti
- Berridge Anthony
- Berry C.
- Betts Sarah
- Bevan Emily
- Bhui K
- Bingham Michelle
- Birchall K
- Bishop L.
- Bisnauthsing Karen
- Blaikely J.
- Bloss Angela
- Bolger A.
- Bolton Charlotte E.
- Bonnington J.
- Botkai A
- Bourne Charlotte
- Bourne Michelle
- Bramham K.
- Brear Lucy
- Breen G
- Breeze Jonathon
- Briggs A.
- Bright E
- Brightling Christopher E
- Brill Simon
- Brindle K
- Broad Lauren
- Broadley A
- Brookes C
- Broome M
- Brown Ammani
- Brown Angela
- Brown J.
- Brown Jeremy S
- Brown Jo
- Brown M.
- Brown M.
- Brown V.
- Brugha Terry
- Brunskill Nigel
- Buch M.
- Buckley Phil
- Bularga A.
- Bullmore E
- Bunker Jenny
- Burden L.
- Burdett Tracy
- Burn D.
- Burns A.
- Burns G.
- Busby J.
- Butcher Robyn
- Butt Al-Tahoor
- Byrne S.
- Cairns P
- Calder P C
- Calvelo Ellen
- Carborn H
- Card Bethany
- Carr Caitlin
- Carr Liesel
- Carson G
- Carter Penny
- Casey A
- Cassar Mark P.
- Cavanagh J
- Chablani Manish
- Chalder Trudie
- Chalmers James D.
- Chambers R C
- Chan Flora
- Channon K M
- Chapman Kerry
- Charalambou A
- Chaudhuri N
- Checkley A
- Chen Jin
- Cheng Yutung
- Chetham Luke
- Childs C
- Chilvers Edwin R
- Chinoy H
- Chiribiri Amedeo
- Chong-James K.
- Choudhury Gourab
- Choudhury N.
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- Warburton Louise
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- Warwick Katie
- Wassall Helen
- Waterson Samuel
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- Weir-McCall Jonathan R
- Welch C
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- Welsh B.
- Wessely S.
- West Sophie
- Weston Heather
- Wheeler H
- White Sonia
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- Wilson Ann
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- Wood Chloe
- Woodhead F
- Woods Janet
- Wootton Daniel G.
- Wormleighton J
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- Wraith D
- Wrey Brown Caroline
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- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
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- Young A.
- Young B.
- Young Susan
- Yousuf A J
- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer - a multicentre observational study
- Author
- Abdullah Nasreen
- Abroaf Ahmed
- Acher Peter
- Adams Robert
- Adasonla Kelvin
- Adimonye Anthony
- Adwin Zainal
- Ager Michael
- Agrawal Sachin
- Ahmad Adnan
- Ahmed Hashim
- Akaln Mustafa Kaan
- Al?Ibraheem Nihad
- Aldiwani Mohammed
- Almpanis Stephanos
- Alonso Cristina Plaza
- Andres Rosado Mario
- Aning Jonathan
- Antón-Juanilla Marta
- Appanna Timson
- Assmus Mark A.
- Austin Tomas
- Ayres Ben
- Bagley Joseph
- Balderas Olga
- Barcelos André
- Bardet Florian
- Barratt Rachel
- Bass Edward
- Bdesha Amar
- Beder Daniel
- Bedi Nishant
- Bele Uros
- Benitez Cayo Augusto Estigarribia
- Bennett Adam
- Bhatt Nikita
- Bi Hai
- Black Peter C
- Blick Chris
- Boltri Matteo
- Bonnin Thierry
- Boxall Nicholas E.
- Brittain James
- Brophy Tom
- Brown Christian
- Brown Kevin
- Browne Clíodhna
- Bullock Nicholas
- Burden Helena
- Burnhope Tara
- Cadena Iván Revelo
- Campain Nicholas
- Capoun Otakar
- Carrion Diego M
- Castillo Elba Canelon
- Catto James
- Cebola Ana
- Chahal Rohit
- Challacombe Ben
- Chan Luke
- Chau Edwin
- Chaudry Aasem
- Chin Yew Fung
- Chippagiri Arvinda
- Chlosta Piotr L
- Chu Timothy Shun Man
- Chuchu Naomi
- Cimarra Fernando
- Claps Francesco
- Clark Jennifer
- Clarke Holly
- Clarke Holly
- Clarke Laurence
- Cohen Daniel
- Cooper Meghan
- Cormier Luc
- Cortes Victor Parejo
- Courcier Jean
- Crawford-Smith Hugh
- Crespo-Atín Víctor
- Crockett Matthew
- Crockett Matthew
- Cruz Ricardo
- Czech Anna K
- Cózar-Olmo Jose Manuel
- Das Arighno
- Davenport Kim
- David Rotimi
- Day Elizabeth
- Deeks Jon
- Deem Samuel
- Dell'Atti Lucio
- Derbyshire Laura
- Desai Ankit
- Desouky Elsayed
- Dhanasekaran Ananda Kumar
- Dhera Karishma
- Dinneen Eoin
- Dowling Catherine
- Downey Alison P.
- Drake Tamsin
- During Vinnie
- Ebur Andrea
- Edison Eric
- Ellis Ricky
- Ellul Tom
- Emberton Mark
- Erotocritou Paul
- Esler Rachel
- Fen Koo Hui
- Feneley Mark
- Fiala Vojtech
- Figueiredo Arnaldo
- Filtekin Yigit
- Forster Luke
- Frankel Jason
- Freire Maria José
- Gadiyar Neha
- Gaines Emily
- Gallagher Kevin M.
- Gallego Maria Camacho
- Gallegos Christopher
- Galosi Andrea B
- Gao Chuanyu
- García de Jalón Ángel
- Garg Tullika
- Gauhar Vineet
- Gillams Kathryn
- Gillams Kathryn
- Glaser Zachary A
- Gnanapragasam Vincent
- Goldsmith Louise
- Gontero Paolo
- Goonewardene Sanchia
- Gordon Daniel
- Gordon Danny
- Green James
- Gresty Helena
- Grigorakis Alkiviadis
- Gronostaj Katarzyna
- Gómez Rivas Juan
- Hale Nathan
- Hamid Syed Sami
- Haroon Usman
- Hawkins Rosalyn
- Hawlina Simon
- He Ming
- Hellawell Giles
- Hernandez Juan
- Hernando Jamie Borrego
- Herranz-Yagüe José Antonio
- Hessell Robert
- Higgs Claire
- Ho Cherrie Wing Yin
- Hobbs Catherine
- Hori Satoshi
- Horie Shigeo
- Houlton Kathleen
- Hrouda David
- Hsu Ray
- Iacovou John
- Ibrahim Ibrahim
- Ibrahim Youssed
- Inder Shakeel Mohammud
- Irani Jacques
- Jain Sunjay
- Jarimba Roberto
- Jefferies Matthew
- Jelski Joseph
- Jones Jennifer
- Joniau Steven
- Kalsi Jas
- Karsza Dávid
- Kasivisvanathan Veeru
- Kata Slawomir Grzegorz
- Kelly John
- Khadhouri Sinan
- Khalid Raihan
- Khan Shahid
- Khawaja Faizan
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- Kitamura Kosuke
- Knight Allen
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- Kouli Omar
- Kovács Gábor
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- Nellensteijn Brechtje
- Ng ChiFai
- Nielsen Matthew
- Nikles Sven
- Nkwam Nkwam
- Nolazco Jose Ignacio
- Norris Joseph
- Nyanhongo Donald
- O'Meara Sorcha
- O'Rourke John
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- Osei?Bonsu Peter K
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- Palagonia Erika
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- Patel Trushar
- Pavan Nicola
- Peters Francesca
- Phan Yih Chyn
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- Pita Hernado Rios
- Pizzuto Giuseppe
- Planelles Paula
- Plo Teresa Cabañuz
- Poves Victoria Capapé
- Puche-Sanz Ignacio
- Qin Zijian
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- Ramos Sónia
- Randhawa Karen
- Raveenthiran Sheliyan
- Rico Luis
- Rintoul-Hoad Sophie
- Ristau Benjamin
- Ritchie Robert
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- Rowe Tracey
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- Sangaralingam Shanthi
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- Sengupta Shomik
- Serag Hosam
- Shah Taimur T.
- Sharma Abhishek
- Sherwood Benedict
- Shrotri Nitin
- Silva Alberto
- Simmons Lucy
- Simpson Helen
- Smith Peter
- Smrkolj Toma
- Stamirowski Remigiusz
- Sukhu Troy
- Suliman Ahmed M
- Suthaharan Denula
- Swami Satchi Kuchibhotla
- Sweeney Paul
- Takwoingi Yemisi
- Tallè Matteo
- Tanasescu George
- Tanasescu Geroge
- Tarin Mohamed
- Tasso Giovanni
- Teoh Jeremy YuenChun
- Testa Joseph
- Thangasamy Isaac
- Tinay Ilker
- Toma Tarq
- Tomakovi Igor
- Toniolo Jason
- Trail Matthew
- Trombetta Carlo
- Turner Stacey
- Tweedle James
- Udzik Jakub
- Ul Ain Qurrat
- Uzan Audrey
- Uçar Taha
- Uçar Taha
- Venturini Stefano
- Villers Arnauld
- Voulgaris Athanasios M
- Vásquez Juan Luis
- Warren Hannah
- Webb Andrew
- Wilby Daniel
- Willemse Peter-Paul Michiel
- Williams Simon
- Wollin Tim
- Wong Albert
- Xylinas Evanguelos
- Y?ld?r?m As?f
- Yan Shahzad Sylvia
- Younis Ayman
- Yuruk Emrah
- Zainuddin Zulkifli
- Zelhof Bachar
- Zimmermann Eleanor F.
- Zotter Zsuzsanna
- Çakurlu Turhan
- Özgür Günal
- Østergren Peter
- Publication venue
- 'Wiley'
- Publication date
- 31/10/2021
- Field of study
Objective
To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation.
Patients and Methods
This was an international multicentre prospective observational study. We included patients aged ≥16 years, referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer, UTUC, renal cancer and prostate cancer; stratified by age, type of haematuria, sex, and smoking. We used a multivariable mixed-effects logistic regression to adjust cancer prevalence for age, type of haematuria, sex, smoking, hospitals, and countries.
Results
Of the 11 059 patients assessed for eligibility, 10 896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n = 2257) was 28.2% (95% confidence interval [CI] 22.3–34.1), bladder cancer (n = 1951) 24.7% (95% CI 19.1–30.2), UTUC (n = 128) 1.14% (95% CI 0.77–1.52), renal cancer (n = 107) 1.05% (95% CI 0.80–1.29), and prostate cancer (n = 124) 1.75% (95% CI 1.32–2.18). The odds ratios for patient risk markers in the model for all cancers were: age 1.04 (95% CI 1.03–1.05; P < 0.001), visible haematuria 3.47 (95% CI 2.90–4.15; P < 0.001), male sex 1.30 (95% CI 1.14–1.50; P < 0.001), and smoking 2.70 (95% CI 2.30–3.18; P < 0.001).
Conclusions
A better understanding of cancer prevalence across an international population is required to inform clinical guidelines. We are the first to report urinary tract cancer prevalence across an international population in patients referred to secondary care, adjusted for patient risk markers and geographical variation. Bladder cancer was the most prevalent disease. Visible haematuria was the strongest predictor for urinary tract cancer
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
- Author
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 01/04/2024
- Field of study
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brain–gut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials
Technology in use (panel session)
- Publication venue
- 'Association for Computing Machinery (ACM)'
- Publication date
- Field of study