8 research outputs found
Pharmacology of (2 S
- Author
- Publication venue
- 'American Society for Pharmacology & Experimental Therapeutics (ASPET)'
- Publication date
- Field of study
Pharmacology of (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2 -methyl[1,1 -biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a new potent and selective nonpeptide antagonist of the oxytocin receptor.
- Author
- Publication venue
- Publication date
- 01/01/2003
- Field of study
ABSTRACT We have discovered a new, potent, selective, and orally active oxytocin receptor antagonist, (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-1-[(2Ј-methyl[1,1Ј-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (compound 1). We report the biochemical, pharmacological, and pharmacokinetic characterization in vitro and in vivo of this compound. Premature birth is a major problem in obstetrics affecting about 10% of all births and being the largest cause of perinatal morbidity and mortality. The impact on society is significant in terms of costs of neonatal intensive care and for the emotional and social stress to the family. The physiopathology of human preterm labor is complex and multifactorial. Preterm increase of uterine activity is a common complication of pregnancy and accounts for many cases of preterm labor. Pharmacological interventions aimed at maintaining uterine quiescence (tocolysis) have been, and are likely to remain, the cornerstone of pharmaceutical management of preterm labor. However, current tocolytic agents (-mimetics, magnesium sulfate, calcium channel blockers, or prostaglandin synthesis inhibitors) suffer from a minimal effectiveness and show important fetal and maternal side effects. Therefore, it is obvious that a safe and effective oral treatment delaying spontaneous preterm birth would have tremendous clinical benefits. The peptide hormone oxytocin (OT) is a potent contractor of the human uterus. OT mediates its effect through activation of the G protein-coupled oxytocin receptor (OT-R) that is expressed in myometrial cells. OT-R is coupled to phospholipase C activation, leading to intracellular synthesis of inositol phosphates and mobilization of calcium. In turn, the rise in intracellular calcium concentration promotes a cascade of events, including phosphorylation of myosin, that then acts on actin and induces uterine muscle cell contraction. Before onset of labor and in the term myometrium, the OT-R density Article, publication date, and citation information can be found a
Transvenous lead extraction from simple traction to transjugular approach
- Author
- Publication venue
- Springer-Verlag Italia srl
- Publication date
- 01/01/2011
- Field of study
Phenotypic spectrum of STRA6 mutations: from matthew-wood syndrome to non-lethal anophthalmia.
- Author
- Publication venue
- country:GBR
- Publication date
- 01/01/2009
- Field of study
International audienceMatthew-Wood, Spear, PDAC or MCOPS9 syndrome are alternative names used to refer to combinations of microphthalmia/anophthalmia, malformative cardiac defects, pulmonary dysgenesis, and diaphragmatic hernia. Recently, mutations in STRA6, encoding a membrane receptor for vitamin A-bearing plasma retinol binding protein, have been identified in such patients. We performed STRA6 molecular analysis in three fetuses and one child diagnosed with Matthew-Wood syndrome and in three siblings where two adult living brothers are affected with combinations of clinical anophthalmia, tetralogy of Fallot, and mental retardation. Among these patients, six novel mutations were identified, bringing the current total of known STRA6 mutations to seventeen. We extensively reviewed clinical data pertaining to all twenty-one reported patients with STRA6 mutations (the seven of this report and fourteen described elsewhere) and discuss additional features that may be part of the syndrome. The clinical spectrum associated with STRA6 deficiency is even more variable than initially described
Discovery of a New Class of Potent, Selective, and Orally Bioavailable CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases #
- Author
- Alexander Scheer
- André Chollet
- Christophe Cleva
- Claudio Giachetti
- Cynthia Rocha
- Doris Pupowicz
- Gérald Bernardinelli
- Jackie Macritchie
- Jean-François Arrighi
- John Atherall
- Lucia Golzio
- Marc Missotten
- Marilène Gaudet
- Matthias K. Schwarz
- Maurizio Maio
- Patrick Page
- Pierre-André Pittet
- Stefano Crosignani
- Thierry Martin
- Véronique Colovray
- Yaroslav Filinchuk
- Yves Humbert
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Cullin3 - BTB Interface: A Novel Target for Stapled Peptides
- Author
- A Amadei
- A Amadei
- A Kumar
- A Merlino
- AJ Kimple
- C Bartels
- C Golzio
- C Griesinger
- C Phillips
- Daniela Mazzà
- DO Sviridov
- DS Wishart
- E De Smaele
- Emilia Pedone
- F Bernal
- G Canettieri
- Gaetano Malgieri
- GH Bird
- GL Verdine
- HE Blackwell
- IS Dementieva
- Ivan de Paola
- JA Marsh
- KA Bixby
- L Di Marcotullio
- L Di Marcotullio
- L Pintard
- L Pirone
- L Pirone
- Laura Zaccaro
- LD Walensky
- Lucia Di Marcotullio
- Luciana Esposito
- Luciano Pirone
- Luigi Russo
- Luigi Vitagliano
- Maddalena Palmieri
- Maria Sola
- MJ Williams
- MV Berjanskii
- Nicole Balasco
- P Canning
- P Genschik
- P Guntert
- PJ Stogios
- R Azizieh
- R Koradi
- RA Laskowski
- RE Moellering
- S Bhattacharya
- S Correale
- S Schwarzinger
- Sonia Di Gaetano
- T Huang
- TL Joseph
- WJ Errington
- X Hu
- Y Bayon
- Y Chen
- ZP Liu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Saturday, 25 August 2012
- Author
- A. Apor
- A. Belo
- A. Berruezo
- A. Birdane
- A. Bochenek
- A. Boem
- A. Bouzas Mosquera
- A. C. Andrade
- A. Castro Beiras
- A. Chernyavskiy
- A. Cremonesi
- A. Di Cori
- A. E. Van Den Bosch
- A. Fanelli
- A. Fanelli
- A. Goedecke
- A. Hager
- A. I. Romero-Aniorte
- A. Ionac
- A. J. J. C. Bogers
- A. J. J. C. Bogers
- A. J. Six
- A. Karaskov
- A. Kasiakogias
- A. Kasiakogias
- A. Kempny
- A. Kempny
- A. Kovacs
- A. Kretschmer
- A. Kutarski
- A. Kutarski
- A. Kutarski
- A. Lopez-Cuenca
- A. M. Maceira Gonzalez
- A. M. S. Olsen
- A. Maciag
- A. Manari
- A. Marzocchi
- A. Mateo-Martinez
- A. Menozzi
- A. Mornos
- A. Nadir
- A. Nagae
- A. Nagy
- A. Nunes
- A. Nunes Diogo
- A. P. J. Van Dijk
- A. Petrescu
- A. Piorkowski
- A. Puzzovivo
- A. Romanov
- A. Uebing
- A. Welz
- A. Zabek
- A. Zimmer
- B. Albrecht-Kuepper
- B. Bacova
- B. Bijnens
- B. Bouzas Zubeldia
- B. E. Backus
- B. Gersak
- B. Herzog
- B. Igual
- B. J. Choi
- B. K. Fleischmann
- B. Malecka
- B. Merkely
- B. Petracci
- B. Ren
- B. Sax
- B. V. Antwerp
- C. Andersson
- C. Andersson
- C. Campo
- C. Chrysohoou
- C. D. Nguyen
- C. Daubert
- C. Felix
- C. Forleo
- C. Hart
- C. I. Santos De Sousa
- C. Izumi
- C. Jacoby
- C. Jorge
- C. Linde
- C. M. Yu
- C. Mornos
- C. Prados
- C. Prados
- C. Rammos
- C. Rickers
- C. Stefanadis
- C. Stefanadis
- C. Stefanadis
- C. Thomopoulos
- C. Torp-Pedersen
- C. Torp-Pedersen
- C. Tsioufis
- C. Tsioufis
- C. Tsioufis
- C. Viczenczova
- C. Vittori
- C. Vlachopoulos
- C. Wackerl
- D. Adam
- D. Bettex
- D. Couto Mallon
- D. Cozma
- D. Dragulescu
- D. Flessas
- D. Levorato
- D. Liu
- D. Martinez Ruiz
- D. Prokhorova
- D. Rizopoulos
- D. Silva
- D. Tousoulis
- D. Tsiachris
- D. Tsiachris
- D. Van Der Linde
- E. Andrikou
- E. Arbelo
- E. C. Bertolino
- E. Gencer
- E. Liodakis
- E. M. W. J. Utens
- E. N. Oechslin
- E. Orenes-Pinero
- E. Pelissero
- E. Pelissero
- E. Pokushalov
- E. Soldati
- E. Y. Yun
- F. Borgia
- F. Ferraris
- F. Gaita
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- F. Gustafsson
- F. J. Broullon
- F. J. Enguita
- F. J. Pinto
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- F. Marin
- F. Monitillo
- F. Mutlu
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- F. Ten Cate
- F. Toyota
- F. Weidemann
- G. Caccamo
- G. Casella
- G. D. Duerr
- G. Ertl
- G. H. Gislason
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- G. Piovaccari
- G. Ruvolo
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- H. Baumgartner
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- H. Kato
- H. Lieu
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- H. M. Yang
- H. Mudra
- H. S. Lim
- H. Ueno
- H. W. Lee
- H. Yokoi
- H.- H. Kramer
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- I. Andrikou
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- I. Kardys
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- J. A. A. E. Cuypers
- J. Aguilar
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- J. Bernhagen
- J. Bis
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- J. Brugada
- J. Burnett
- J. C. Choi
- J. C. Yanez Wonenburger
- J. Cosin Sales
- J. Estornell
- J. Greenslade
- J. Gruenenfelder
- J. H. Ahn
- J. H. Choi
- J. H. Oh
- J. H. Ruiter
- J. H. Shin
- J. Hess
- J. Hoerer
- J. J. M. Takkenberg
- J. L. Diago
- J. L. Januzzi
- J. L. Looi
- J. M. Tolosana
- J. Mcghie
- J. Mueller
- J. Navarova
- J. Neutel
- J. Peteiro
- J. Radosinska
- J. Ruvira
- J. Segovia
- J. Segovia
- J. Sobierajski
- J. Sosna
- J. V. Monmeneu
- J. Vecera
- J. W. Kim
- J. W. Roos-Hesselink
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- K. Ando
- K. Bogaard
- K. Dimopoulos
- K. Dimopoulos
- K. Fattouch
- K. Goscinska-Bis
- K. Hanazawa
- K. Harada
- K. Hu
- K. Kaitani
- K. Kintis
- K. Kintis
- K. S. Cha
- K. U. Mert
- K. W. Seo
- K. Wustmann
- K. Yamada
- L. A. Alonso Pulpon
- L. Baerfacker
- L. Cullen
- L. De Groot-De Laat
- L. Kober
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- L. Lioni
- L. M. Belotti
- L. Maiz
- L. Maiz
- L. Mont
- L. Paperini
- L. Petrescu
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- L. Ruiz Bautista
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- L. Swan
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- M. A. Castel
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- M. A. Gatzoulis
- M. A. Gatzoulis
- M. A. Russ
- M. A. Weber
- M. B. Nielsen
- M. Chudzik
- M. Cikes
- M. Cipriani
- M. Costa
- M. Czajkowski
- M. Czajkowski
- M. Dewor
- M. E. Menting
- M. E. Trucco
- M. Fiuza
- M. Frigerio
- M. G. Bongiorni
- M. G. Charlot
- M. Geleijnse
- M. Giakoumis
- M. Gonzalez Estecha
- M. H. Yacoub
- M. H. Yoon
- M. Heikenwaelder
- M. Hochadel
- M. Hyodo
- M. Iacoviello
- M. Iwabuchi
- M. Jerosch-Herold
- M. Kelm
- M. Kelm
- M. Kempa
- M. Khatib
- M. Koren
- M. Landolina
- M. Luedde
- M. Lunati
- M. Lutz
- M. Madsen
- M. Martinez
- M. Morello
- M. Niemann
- M. Nobuyoshi
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- M. P. Lopez Lereu
- M. Penicka
- M. Pham
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- M. Sanchez-Martinez
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- M. Valdes-Chavarri
- M. Valgimigli
- M. Vanderheyden
- M. Vinci
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- M. Witsenburg
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- M. Zeman
- N. Alvarez Garcia
- N. Carter
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- O. Bodea
- O. Dewald
- O. Gaemperli
- P. Biaggi
- P. Carrilho-Ferreira
- P. Guastaroba
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- P. Mitkowski
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- P. Stock
- P. W. Lee
- P.- G. Golzio
- P.- G. Golzio
- R. Alonso-Gonzalez
- R. Borras
- R. Corti
- R. De Lucia
- R. Fabregas Casal
- R. Giron
- R. Giron
- R. Jenni
- R. Kast
- R. Pietura
- R. Sampognaro
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- R. Weber
- S. B. Christensen
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- S. Bisetti
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- T. Kameyama
- T. Katsimichas
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- T. Klaas
- T. Kumamoto
- T. L. Bergemann
- T. Nakadate
- T. Noto
- T. Rassaf
- T. Rassaf
- T. Sato
- T. Ulus
- U. Floegel
- U. Hendgen-Cotta
- U. Hendgen-Cotta
- U. Zeymer
- V. A. Umans
- V. Antonakis
- V. Antoncecchi
- V. Dosenko
- V. Knezl
- V. Marangelli
- V. Monivas
- V. Monivas Palomero
- V. Shabanov
- V. Tzamou
- W. A. Helbing
- W. Budts
- W. Grosso Marra
- W. Li
- W. Roell
- W. T. Abraham
- W. Vletter
- Y. Cavusoglu
- Y. Nakagawa
- Y. Takabatake
- Y. Takasawa
- Y. Y. Lam
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
ABSTRACTS
- Author
- E
- S
- Abbate R
- Abbey S
- Abdelaal A
- Abdelwahab A
- Abdollah H
- Abe H
- Abecasis J
- Aboelhoda A
- Abraham P
- Abreu A
- Accadia M
- Achille F
- Adachi M
- Adams D
- Adamyan K
- Adgey A
- Adragao P
- Adrianov A
- Adsett M
- Agarwal S
- Aggio S
- Aghamohammadzadeh R
- Agladze R
- Aguilar P
- Ahmed S
- Ahn M
- Aihara N
- Aime E
- Airaksinen J
- Al-Shawabkeh N
- Alasti M
- Albacete-Moreno C
- Albenque J
- Albertsen A
- Albinni S
- Alboni P
- Aldhoon B
- Aleksic I
- Alessandrini F
- Alexandru R
- Alexopoulos D
- Algalarrondo V
- Alhous H
- Ali M
- Ali N
- Aliot E
- Alizadeh A
- Allaart C
- Allen J
- Allocca G
- Almeida A
- Almeida M
- Almeida S
- Almendral J
- Almendro M
- Almor J
- Alonso A
- Alonso J
- Altaba C
- Alvarenda C
- Alvarenga C
- Alvarez J
- Alves L
- Alves S
- Aly R
- Alzueta J
- Amati F
- Ambrose M
- Amellone C
- Amikam S
- Amlie J
- Ammann P
- Ammar R
- Ammar S
- Andersen K
- Anderson J
- Andersson F
- Ando K
- Andraos A
- Andresen D
- Andreu D
- Andronache M
- Anelli-Monti M
- Angeloni G
- Anger Z
- Angheben C
- Anichkov D
- Anjos R
- Anker S
- Anselme F
- Anselmino M
- Antolini M
- Antoni D
- Antoniadis A
- Antonio N
- Antoniou A
- Antzelevitch C
- Aonuma K
- Apiyasawat S
- Arad M
- Aragoncillo P
- Arana E
- Araujo I
- Arbelo E
- Archondo T
- Archontakis S
- Arenal A
- Arentz T
- Argyle R
- Arie T
- Arita T
- Arkolaki E
- Armaganijan L
- Armanijian L
- Arnar D
- Arribas F
- Arriezu L
- Arroja I
- Arsenos P
- Artemenko S
- Artuza C
- Arujna A
- Arvanitis P
- Asano T
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- Asensi J
- Ashrafpoor G
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- Atea L
- Ateia I
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- Atsma D
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- Avella A
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- Averina V
- Averyanov A
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- Aydogdu S
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- Berruezo A
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- Bogalho C
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- Bollmann A
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- Bordier S
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- Borleffs C
- Borrego I
- Bortnik M
- Bortolazzi A
- Bortone A
- Bostanitis I
- Bostock J
- Botelho A
- Botto G
- Boudoulas H
- Boughzela E
- Boulogne E
- Boulos M
- Bountonas G
- Boussy T
- Boveda S
- Bowes R
- Boyko V
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- Braunschweig F
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- Breithardt G
- Breithardt O
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- Brooks A
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- Bueno F
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- Burkhardt J
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- Bzukala I
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- Calo L
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- Camm A
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- Canbay A
- Canciello M
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- Cao F
- Capucci A
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- Cardiga R
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- Carreras G
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- Casella M
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- Casolo G
- Casset C
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- Castellant P
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- Castillo R
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- Catanzariti D
- Cate F
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- Celentano E
- Celorrio V
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