3,681 research outputs found

    SUSTAINABLE PRACTICES IN THE TOURISM INDUSTRY. EXPLORING THE BENEFITS OF THE CRADLE TO CRADLE CONCEPT

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    With all the new developments in the technology field, entrepreneurs around the world have proven than there are innovations which can be transferred and implemented into the tourism industry. This new types of business focus on social, economic and environmental sustainability that enter in the circular economy sphere, where a different mind-set is in the centre of things. This paper explores the cradle to cradle concept and its applicability in the tourism industry

    SUSTAINABLE DECISION MAKING UNDER THE CRISIS FOR TOURISM BUSINESSES: A SURVEY OF THE LITERATURE FOR EU MEMBER STATES

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    The last years have proven to be particular problematic for member states of UE because of the financial crisis. When we discus about tourism businesses and the measures undertaken by managers to mitigate the effects of the crisis some of them were to reduce the part allocated for expenditures regarding innovation, technologic improvements and went for different types of approaches. An increased attention has been given to sustainable development, sustainable marketing and development in environmental accounting techniques and in our research we explore how they changed the course of the core of the business and how these initiatives are realistic. The overall finding is that sustainable actions exist and they are present in many strategies but they are poorly translated in real actions

    Quinoxaline chemistry. Part 8. 2-[anilino]-3- [carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity

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    Thirty quinoxalines bearing a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5 and 10-4 molar concentrations. Interesting selectivities were also recorded between 10-8 and 10-6 M for a few compounds. One single compound exhibited good activity against Candida Albicans

    ON THE ROLE OF BENCHMARKING IN THE HIGHER EDUCATION QUALITY ASSESSMENT

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    Increasing competition, demands for accountability, and higher volumes ofavailable information are changing the methods of how institutions of higher educationoperate in nowadays. For higher education to enact substantial and sustainable changesin efficiency and productivity a new way of thinking or paradigm that builds efficiencyand a desire for continual learning must be integrated into institutional structures. Toolsare also being developed that measure or benchmark the progress and success of theseefforts. Among the improvement strategies and techniques, benchmarking has emerged asa useful, easily understood, and effective tool for staying competitive. This is why thepresent article aims to emphasize the importance of benchmarking in the highereducation quality assessment.benchmarking, higher education, quality, management

    Identification of side population cells in mouse primordial germ cells and prenatal testis

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    In mammals, the stem cells of spermatogenesis are derived from an embryonic cell population called primordial germ cells (PGCs). Spermatogonial stem cells displaying the "side population" (SP) phenotype have been identified in the immature and adult mouse testis, but noting is known about the expression of the SP phenotype during prenatal development of germ cells. The SP phenotype, defined as the ability of cells to efflux fluorescent dyes such as Hoechst, is common to several stem/progenitor cell types. In the present study, we analyzed and characterized the Hoechst SP via cytofluorimetric analysis of disaggregated gonads at different time points during embryonic development in mice. To directly test the hypothesis that the SP phenotype is a feature of germ cell lineage, experiments were performed on transgenic animals expressing enhanced green fluorescent protein (EGFP) under the control of the Oct4 promoter, to identify early germ cells up to PGCs. We found that prenatal gonads contain a fraction of SP cells at each stage analyzed, and the percentage of cells in the SP fraction decreases as development proceeds. Surprisingly, more than 50% of the PGCs displayed the SP phenotype at 11.5 dpc (days post coitum). The percentage of germ cells with the SP phenotype decreased steadily with development, to less than 1% at 18.5 dpc. Cytofluorimetric analysis along with immunocytochemistry performed on sorted cells indicated that the SP fraction of prenatal gonads, as in the adult testis, was heterogeneous, being composed of both somatic and germ cells. Both cell types expressed the ABC transporters Abcg2, Abcb1a, Abcb1b and Abcc1. These findings provide evidence that the SP phenotype is a common feature of PGCs and identifies a subpopulation of fetal testis cells including prospermatogonia whose differentiation fate remains to be investigated. © 2011 UBC Press

    Effect of Electro-kinetic Consolidation on Fine Grained Dredged Sediments

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    Abstract The management of the huge amount of dredged sediments is an important issue to be solved worldwide, and dewatering is by far the most critical step when fine grained sediments are involved. Different technologies have been proposed in time to speed up the process. Even though electro-kinetic treatment is in principle one of them, it has not been implemented yet at an industrial scale, and only few trial applications are known. For such a reason, a multidisciplinary research activity is ongoing at the University of Napoli Federico II in the framework of the EU commitment ROSE with the aim to analyse the effectiveness and feasibility of such a technology from the lab to the site scale. In this paper, some evidences stemming from lab tests are presented. The results indicate that the application of low voltages improves the mechanical behaviour of the tested soil. In this case, however, the improvement is due more to a change in microstructure than to a decrease in void ratio
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