SOCIAL AND PSYCHOLOGICAL CONDITIONS OF JUVENILE CONVICTS’ RESOCIALIZATION IN THE PROBATION SERVICE

The article studies social and psychological conditions of juvenile convicts’ resocialization in the probation service. Serving animprisonment sentence leads juvenile offenders to lose their social skills and it is difficult for them to adapt in society, because the personality of a juvenile offender regresses in isolation. Due to the humanization of criminal policy in Ukraine, the judicial system is changing to give preference to alternative punishments, not related to imprisonment. One such re-socializing form for juvenile offenders is probation. This punishment avoids adolescent social isolation during the most important period of personality formation.The main stages of social-psychological work with juveniles sentenced to alternative punishments are: examination of their personality, determination of measures and methods having effective social-psychological influence on them, preparation of individual resocialization programs and adolescents’ integration to societyon the basis of these programs. We determined the content of social workers’ work to re-socialize juvenile offenders.During our empirical study, we analysed documents and organised a survey to examine social workers’ functions in working with juvenile convicts and determine an expert opinion about the need for a social worker position in the probation services where juvenile convicts were registered.The sample consisted of specialists from the probation services of the city of Kyiv and Kyiv region, who worked with juvenile convicts, totally, 28 respondents.The empirical data revealed that, mainly, the specialists in law studied the features of adolescents’ personality traits and upbringing. Probation services did not have social workers in their working structure. And these facts, in turn, makes it impossible to provide high-quality resocialization. In particular, the pre-trial reports, risk assessment for repeated criminal offenses, work with juvenile convicts’ parents, organization of constructive leisure, etc. are performed by specialists without any competencies in social work.However, according to the empirical data, respondents believed that specialists in social work should participate actively in resocialization of juvenile convicts, as they would understand the features of adolescence and, therefore, would be able towork in cooperation to assess qualitatively recidivism, assist and encourage adolescents to study and get an education. Keywords: resocialization, probation, social work, convicted adolescents

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Indirect co-cultivation of HepG2 with differentiated THP-1 cells induces AHR signalling and release of pro-inflammatory cytokines

HepG2 and THP-1 cells, the latter differentiated by phorbol 12-myristate 13-acetate (PMA), were co-cultured and characterized for typical liver-specific functions, such as xenobiotic detoxification, lipid and cholesterol metabolism. Furthermore, liver injury-associated pathways, such as inflammation, were studied. In general, the co-cultivation of these cells produced a pro-inflammatory system, as indicated by increased levels of cytokines (IL-8, TGF-alpha, IL-6, GM-CSF, G-CSF, TGF-beta, and hFGF) in the respective supernatant. Increased expression levels of target genes of the aryl hydrocarbon receptor (AHR), e.g., CYP1A1, CYP1A2 and CYP1B1, were detected, accompanied by the increased enzyme activity of CYP1A1. Moreover, transcriptome analyses indicated a significant upregulation of cholesterol biosynthesis, which could be reduced to baseline levels by lovastatin. In contrast, total de novo lipid synthesis was reduced in co-cultured HepG2 cells. Key events of the adverse outcome pathway (AOP) for fibrosis were activated by the co-cultivation, however, no increase in the concentration of extracellular collagen was detected. This indicates, that AOP should be used with care. In summary, the indirect co-culture of HepG2/THP-1 cells results in an increased release of pro-inflammatory cytokines, an activation of the AHR pathway and an increased enzymatic CYP1A activity

The nuclear entry of the aryl hydrocarbon receptor (AHR) relies on the first nuclear localization signal and can be negatively regulated through IMPα/β specific inhibitors

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Optical sensing in urban areas by deployed telecommunication fiber networks

The telecommunication fiber network already deployed in urban areas provides an added value to the optical asset itself, allowing a smart monitoring of our cities in a large scale. It is possible to use deployed PON infrastructures for structural vibration and local seismologic perturbations monitoring. On the other hand, surveillance of the embedded network and real-time safety diagnostic is also possible. The invited talk will present different experimental demonstrations to show the sensing performance by exploiting deployed fiber links, assessing the compatibility with the optical data telecom traffic at very high rate

Commensal-Related Changes in the Epidermal Barrier Function Lead to Alterations in the Benzo[a]Pyrene Metabolite Profile and Its Distribution in 3D Skin

Polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene (B[a]P) are among the most abundant environmental pollutants, resulting in continuous exposure of human skin and its microbiota. However, effects of the latter on B[a]P toxicity, absorption, metabolism, and distribution in humans remain unclear. Here, we demonstrate that the skin microbiota does metabolize B[a]P on and in human skin in situ, using a recently developed commensal skin model. In this model, microbial metabolism leads to high concentrations of known microbial B[a]P metabolites on the surface as well as in the epidermal layers. In contrast to what was observed for uncolonized skin, B[a]P and its metabolites were subject to altered rates of skin penetration and diffusion, resulting in up to 58% reduction of metabolites recovered from basal culture medium. The results indicate the reason for this altered behavior to be a microbially induced strengthening of the epidermal barrier. Concomitantly, colonized models showed decreased formation and penetration of the ultimate carcinogen B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE), leading, in consequence, to fewer BPDE-DNA adducts being formed. Befittingly, transcript and expression levels of key proteins for repairing environmentally induced DNA damage such as xeroderma pigmentosum complementation group C (XPC) were also found to be reduced in the commensal models, as was expression of B[a]P-associated cytochrome P450-dependent monooxygenases (CYPs). The results show that the microbiome can have significant effects on the toxicology of external chemical impacts. The respective effects rely on a complex interplay between microbial and host metabolism and microbe-host interactions, all of which cannot be adequately assessed using single-system studies. IMPORTANCE Exposure to xenobiotics has repeatedly been associated with adverse health effects. While the majority of reported cases relate to direct substance effects, there is increasing evidence that microbiome-dependent metabolism of xenobiotic substances likewise has direct adverse effects on the host. This can be due to microbial biotransformation of compounds, interaction between the microbiota and the host’s endogenous detoxification enzymes, or altered xenobiotic bioavailability. However, there are hardly any studies addressing the complex interplay of such interactions in situ and less so in human test systems. Using a recently developed microbially competent three-dimensional (3D) skin model, we show here for the first time how commensal influence on skin physiology and gene transcription paradoxically modulates PAH toxicity

Exploitation of deployed telecommunication fiber infrastructures for sensing applications

The optical fiber infrastructure deployed in our cities to support the metropolitan area networks is exploited for sensing applications, where the optical sensing signals co-propagate together with the telecom traffic. Thanks to a coherent interferometric approach, structural monitoring of buildings can be achieved in deployed passive optical networks based on fiber-to-the-home structure. Moreover, the same technology is experimented in urban fibre ring networks to detect and localize mechanical vibrations or dynamic perturbation

Regulation of Nucleotide Excision Repair by UV-DDB: Prioritization of Damage Recognition to Internucleosomal DNA

This study reveals the molecular mechanism by which the nucleotide excision repair protein DDB2 prioritises excision of UV-induced DNA lesions in the nucleosome landscape

Data on ADME parameters of bisphenol A and its metabolites for use in physiologically based pharmacokinetic modelling

The paper presents the collection of physicochemical parameters of bisphenol A (BPA) and its sulfate (BPAS) and glucuronide (BPAG) conjugates, accompanied by data characterizing their absorption, distribution, metabolism and excretion (ADME) behavior following oral administration of BPA. The data were collected from open literature sources and publicly available databases. Additionally, data calculated by using the MarvinSketch 18.30.0 software or predicted by relevant QSAR models built in Simcyp® Simulator were also used. All data were analysed and are fit for purpose if necessary to ensure a reliable prediction of pharmacokinetics of BPA and its conjugates. The data selection process and reasoning for fitting is provided to allow critical assessment and to ensure data transparency. Finally, the sensitivity analysis was performed to assess the influence of the selected parameters on the PBPK model predictions