38 research outputs found
High Speed Chaos in Optical Feedback System with Flexible Timescales
We describe a new opto-electronic device with time-delayed feedback that uses
a Mach-Zehnder interferometer as passive nonlinearity and a semiconductor laser
as a current-to-optical-frequency converter. Bandlimited feedback allows tuning
of the characteristic time scales of both the periodic and high dimensional
chaotic oscillations that can be generated with the device. Our implementation
of the device produces oscillations in the frequency range of tens to hundreds
of MHz. We develop a model and use it to explore the experimentally observed
Andronov-Hopf bifurcation of the steady state and to estimate the dimension of
the chaotic attractor.Comment: 7 pages, 6 figures, to be published in IEEE J. Quantum Electro
All-Optical Switching with Transverse Optical Patterns
We demonstrate an all-optical switch that operates at ultra-low-light levels
and exhibits several features necessary for use in optical switching networks.
An input switching beam, wavelength , with an energy density of
photons per optical cross section [] changes
the orientation of a two-spot pattern generated via parametric instability in
warm rubidium vapor. The instability is induced with less than 1 mW of total
pump power and generates several Ws of output light. The switch is
cascadable: the device output is capable of driving multiple inputs, and
exhibits transistor-like signal-level restoration with both saturated and
intermediate response regimes. Additionally, the system requires an input power
proportional to the inverse of the response time, which suggests thermal
dissipation does not necessarily limit the practicality of optical logic
devices
Controlling Fast Chaos in Delay Dynamical Systems
We introduce a novel approach for controlling fast chaos in time-delay
dynamical systems and use it to control a chaotic photonic device with a
characteristic time scale of ~12 ns. Our approach is a prescription for how to
implement existing chaos control algorithms in a way that exploits the system's
inherent time-delay and allows control even in the presence of substantial
control-loop latency (the finite time it takes signals to propagate through the
components in the controller). This research paves the way for applications
exploiting fast control of chaos, such as chaos-based communication schemes and
stabilizing the behavior of ultrafast lasers.Comment: 4 pages, 4 figures, to be published in Physical Review Letter
All-optical switching in rubidium vapor
We report on an all-optical switch that operates at low light levels. It
consists of laser beams counterpropagating through a warm rubidium vapor that
induce an off-axis optical pattern. A switching laser beam causes this pattern
to rotate even when the power in the switching beam is much lower than the
power in the pattern. The observed switching energy density is very low,
suggesting that the switch might operate at the single-photon level with system
optimization. This approach opens the possibility of realizing a single-photon
switch for quantum information networks and for improving transparent optical
telecommunication networks.Comment: 20 pages, 6 figures; published in Science;
http://www.sciencemag.org/cgi/content/short/308/5722/67
Experiments with a Malkus-Lorenz water wheel: Chaos and Synchronization
We describe a simple experimental implementation of the Malkus-Lorenz water
wheel. We demonstrate that both chaotic and periodic behavior is found as wheel
parameters are changed in agreement with predictions from the Lorenz model. We
furthermore show that when the measured angular velocity of our water wheel is
used as an input signal to a computer model implementing the Lorenz equations,
high quality chaos synchronization of the model and the water wheel is
achieved. This indicates that the Lorenz equations provide a good description
of the water wheel dynamics.Comment: 12 pages, 7 figures. The following article has been accepted by the
American Journal of Physics. After it is published, it will be found at
http://scitation.aip.org/ajp
Hopf bifurcations in time-delay systems with band-limited feedback
We investigate the steady-state solution and its bifurcations in time-delay
systems with band-limited feedback. This is a first step in a rigorous study
concerning the effects of AC-coupled components in nonlinear devices with
time-delayed feedback. We show that the steady state is globally stable for
small feedback gain and that local stability is lost, generically, through a
Hopf bifurcation for larger feedback gain. We provide simple criteria that
determine whether the Hopf bifurcation is supercritical or subcritical based on
the knowledge of the first three terms in the Taylor-expansion of the
nonlinearity. Furthermore, the presence of double-Hopf bifurcations of the
steady state is shown, which indicates possible quasiperiodic and chaotic
dynamics in these systems. As a result of this investigation, we find that
AC-coupling introduces fundamental differences to systems of Ikeda-type [Ikeda
et al., Physica D 29 (1987) 223-235] already at the level of steady-state
bifurcations, e.g. bifurcations exist in which limit cycles are created with
periods other than the fundamental ``period-2'' mode found in Ikeda-type
systems.Comment: 32 pages, 5 figures, accepted for publication in Physica D: Nonlinear
Phenomen
Dapsoneâ and nitroso dapsoneâspecific activation of T cells from hypersensitive patients expressing the risk allele HLAâB*13:01
BACKGROUND:Research into drug hypersensitivity associated with expression of specific HLA alleles has focussed on the interaction between parent drug and the HLA with no attention given to reactive metabolites. For this reason, we have studied HLA-B*13:01-linked dapsone hypersensitivity to (1) explore whether the parent drug and/or nitroso metabolite activates T-cells and (2) determine whether HLA-B*13:01 is involved in the response. METHODS:PBMC from 6 patients were cultured with dapsone and nitroso dapsone and proliferative responses and IFN-Îł release were measured. Dapsone- and nitroso dapsone-specific T-cell clones were generated and phenotype, function, HLA allele restriction and cross-reactivity assessed. Dapsone intermediates were characterized by mass spectrometry. RESULTS:PBMC from 6 patients and cloned T-cells proliferated and secreted Th1/2/22 cytokines when stimulated with dapsone (clones: n=395; 80% CD4+ CXCR3hi CCR4hi , 20% CD8+CXCR3hi CCR4hi CCR6hi CCR9hi CCR10hi ) and nitroso dapsone (clones: n=399; 78% CD4+, 22% CD8+ with same chemokine receptor profile). CD4+ and CD8+ clones were HLA-class II and class I restricted, respectively, and displayed three patterns of reactivity: compound-specific, weakly crossreactive and strongly cross reactive. Nitroso dapsone formed dimers in culture and was reduced to dapsone, providing a rationale for the crossreactivity. T-cell responses to nitroso dapsone were dependent on the formation of a cysteine-modified protein adduct, while dapsone interacted in a labile manner with antigen presenting cells. CD8+ clones displayed an HLA-B*13:01-restricted pattern of activation. CONCLUSION:These studies describe the phenotype and function of dapsone- and nitroso dapsone-responsive CD4+ and CD8+ T-cells from hypersensitive patients. Discovery of HLA-B*13:01-restricted CD8+ T-cell responses indicates that drugs and their reactive metabolites participate in HLA allele-linked forms of hypersensitivity. This article is protected by copyright. All rights reserved
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICARâRS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICARâRSâ2021 as well as updates to the original 140 topics. This executive summary consolidates the evidenceâbased findings of the document. Methods: ICARâRS presents over 180 topics in the forms of evidenceâbased reviews with recommendations (EBRRs), evidenceâbased reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICARâRSâ2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidenceâbased management algorithm is provided. Conclusion: This ICARâRSâ2021 executive summary provides a compilation of the evidenceâbased recommendations for medical and surgical treatment of the most common forms of RS