Local transformations of units in Scalar-Tensor Cosmology

The physical equivalence of Einstein and Jordan frame in Scalar Tensor theories has been explained by Dicke in 1962: they are related by a local transformation of units. We discuss this point in a cosmological framework. Our main result is the construction of a formalism in which all the physical observables are frame-invariant. The application of this approach to CMB codes is at present under analysis.Comment: To appear in the proceedings of IRGAC 2006, 2nd International Conference on Quantum Theories and Renormalization Group in Gravity and Cosmology, Barcelona, July 11-15 200

Einstein and Jordan frames reconciled: a frame-invariant approach to scalar-tensor cosmology

Scalar-Tensor theories of gravity can be formulated in different frames, most notably, the Einstein and the Jordan one. While some debate still persists in the literature on the physical status of the different frames, a frame transformation in Scalar-Tensor theories amounts to a local redefinition of the metric, and then should not affect physical results. We analyze the issue in a cosmological context. In particular, we define all the relevant observables (redshift, distances, cross-sections, ...) in terms of frame-independent quantities. Then, we give a frame-independent formulation of the Boltzmann equation, and outline its use in relevant examples such as particle freeze-out and the evolution of the CMB photon distribution function. Finally, we derive the gravitational equations for the frame-independent quantities at first order in perturbation theory. From a practical point of view, the present approach allows the simultaneous implementation of the good aspects of the two frames in a clear and straightforward way.Comment: 15 pages, matches version to be published on Phys. Rev.

Heart Rate Variability as a Tool for Seizure Prediction: A Scoping Review

: The most critical burden for People with Epilepsy (PwE) is represented by seizures, the unpredictability of which severely impacts quality of life. The design of real-time warning systems that can detect or even predict ictal events would enhance seizure management, leading to high benefits for PwE and their caregivers. In the past, various research works highlighted that seizure onset is anticipated by significant changes in autonomic cardiac control, which can be assessed through heart rate variability (HRV). This manuscript conducted a scoping review of the literature analyzing HRV-based methods for detecting or predicting ictal events. An initial search on the PubMed database returned 402 papers, 72 of which met the inclusion criteria and were included in the review. These results suggest that seizure detection is more accurate in neonatal and pediatric patients due to more significant autonomic modifications during the ictal transitions. In addition, conventional metrics are often incapable of capturing cardiac autonomic variations and should be replaced with more advanced methodologies, considering non-linear HRV features and machine learning tools for processing them. Finally, studies investigating wearable systems for heart monitoring denoted how HRV constitutes an efficient biomarker for seizure detection in patients presenting significant alterations in autonomic cardiac control during ictal events

Quantitative analysis of dynamic computed tomography angiography for the detection of endoleaks after abdominal aorta aneurysm endovascular repair:A feasibility study

ObjectivesTo assess the feasibility of quantitative analysis of dynamic computed tomography angiography (dCTA) for the detection of endoleaks in patients who underwent endovascular repair of abdominal aortic aneurysms (EVAR).Material and methodsTwenty patients scheduled for contrast-enhanced CT angiography (CTA) of the abdominal aorta post-EVAR were prospectively enrolled. All patients received a standard triphasic CTA protocol, followed by an additional dCTA. The dCTA acquisition enabled reconstruction of color-coded maps depicting blood perfusion and a dCTA dataset of the aneurysm sac. Observers assessed the dCTA and dynamic CT perfusion (dCTP) images for the detection of endoleaks, establishing diagnostic confidence based on a modified 5-point Likert scale. An index was calculated for the ratio between the endoleak and aneurysm sac using blood flow for dCTP and Hounsfield units (HU) for dCTA. The Wilcoxon test compared the endoleak index and the diagnostic confidence of the observers.ResultsIn total, 19 patients (18 males, median age 74 years [70.5-75.7]) were included for analysis. Nine endoleaks were detected in 7 patients using triphasic CTA as the reference standard. There was complete agreement for endoleak detection between the two techniques on a per-patient basis. Both dCTA and dCTP identified an additional endoleak in one patient. The diagnostic confidence using dCTP for detection of endoleaks was not significantly superior to dCTA (5.0 [5-5] vs. 4.5 [4-5], respectively; p = 0.11); however, dCTP demonstrated superior diagnostic confidence for endoleak exclusion compared to dCTA (1.0 [1-1] vs 1.5 [1.5-1.5], respectively; p ConclusionsQuantitative analysis of dCTP imaging can aid in the detection of endoleaks and demonstrates a higher endoleak detection rate than triphasic CTA, as well as a strong correlation with visual assessment of dCTA images

Predictive Value of Cardiac CTA, Cardiac MRI, and Transthoracic Echocardiography for Cardioembolic Stroke Recurrence

Background: Transthoracic echocardiography (TTE) is the standard of care for initial evaluation of patients with suspected cardioembolic stroke. While TTE is useful for assessing certain sources of cardiac emboli, its diagnostic capability is limited in the detection of other sources, including left atrial thrombus and aortic plaques. Objectives: To investigate sensitivity, specificity and predictive value of cardiac CT angigography (cCTA), cardiac MRI (CMR), and TTE for recurrence in patients with suspected cardioembolic stroke. Methods: We retrospectively included 151 patients with suspected cardioembolic stroke who underwent TTE and either CMR (n=75) or cCTA (n=76) between January 2013 and May 2017. We evaluated for presence of left atrial thrombus, left ventricular thrombus, vulnerable aortic plaque, cardiac tumors, and valvular vegetation as causes of cardioembolic stroke. The end-point was stroke recurrence. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for recurrent stroke were calculated; the diagnostic accuracy of CMR, cCTA, and TTE was compared between and within groups using area under the curves (AUCs). Results: Twelve and 14 recurrent strokes occurred in the cCTA and CMR groups, respectively. Sensitivity, specificity, PPV and NPV were: 33.3%, 93.7%, 50.0%, and 88.2% for cCTA; 14.3%, 80.3%, 14.3%, and 80.3% for CMR; 14.3%, 83.6%, 16.7%, 80.9% for TTE in the CMR group, and 8.3%, 93.7%, 20.0% and 84.5% for TTE in the cCTA group. Accuracy was not different (p>0.05) between cCTA (0.63, 95% CI [0.49, 0.77]), CMR (0.53, [0.42, 0.63]), TTE in CMR group (0.51, [0.40, 0.61], and TTE in cCTA group (0.51, [0.42, 0.59]). In cCTA group, atrial and ventricular thrombus were detected by cCTA in 3 patients and TTE in 1 patient; in CMR group, thrombus was detected by CMR in 1 patient and TTE in 2 patients. Conclusion: cCTA, CMR, and TTE showed comparably high specificity and NPV for cardioembolic stroke recurrence. cCTA and CMR may be valid alternatives to TTE. cCTA may be preferred given potentially better detection of atrial and ventricular thrombus. Clinical impact: cCTA and CMR have similar clinical performance as TTE for predicting cardioembolic stroke recurrence. This observation may be especially important when TTE provides equivocal findings

Piroxicam and intracavitary platinum-based chemotherapy for the treatment of advanced mesothelioma in pets: preliminary observations

Malignant Mesothelioma is an uncommon and very aggressive tumor that accounts for 1% of all the deaths secondary to malignancy in humans. Interestingly, this neoplasm has been occasionally described in companion animals as well. Aim of this study was the preclinical evaluation of the combination of piroxicam with platinum-based intracavitary chemotherapy in pets. Three companion animals have been treated in a three years period with this combination. Diagnosis was obtained by ultrasonographic exam of the body cavities that evidenced thickening of the mesothelium. A surgical biopsy further substantiated the diagnosis. After drainage of the malignant effusion from the affected cavity, the patients received four cycles of intracavitary CDDP at the dose of 50 mg/m2 every three weeks if dogs or four cycles of intracavitary carboplatin at the dose of 180 mg/m2 (every 3 weeks) if cats, coupled with daily administration of piroxicam at the dose of 0.3 mg/kg. The therapy was able to arrest the effusion in all patients for variable remission times: one dog is still in remission after 3 years, one dog died of progressive disease after 8 months and one cat died due to progressive neoplastic growth after six months, when the patient developed a mesothelial cuirass. The combination showed remarkable efficacy at controlling the malignant effusion secondary to MM in our patients and warrants further investigations

A Consistent High-Resolution Catalog of Induced Seismicity in Basel Based on Matched Filter Detection and Tailored Post-Processing

Seismic monitoring of the Basel Enhanced Geothermal System (EGS) has been running for more than a decade. Yet, the details of the long-term behavior of its induced seismicity remained unexplored because a seismic event catalog with consistent detection sensitivity and magnitudes did not exist. This knowledge is essential for developing guidelines and mitigation procedures on how to safely operate and terminate injection activities. Only few observational data exist that cover all phases of such projects in a consistent manner. Here, we describe a method that overcomes these deficiencies based on sensitive matched filter detection and a machine learning approach to remove false detections. With an emphasis on consistency, we create a catalog that contains more than 280 000 events down to Mw−1.5. The much higher temporal resolution allows us to analyze induced microearthquakes in great detail and to gain new insights. We resolved temporal variations of seismicity parameters and, in the post-operational phase, a preferential temporal clustering of events. We find a breakdown in the Gutenberg--Richter scaling during reservoir stimulation, which may have physical reasons or could be caused by a method-independent detection limit during high event rates. The scaling breakdown has implications for the design of Adaptive Traffic Light Systems and may limit the potential of real-time mitigation strategies in future EGS projects. Nevertheless, our catalog gives the opportunity to study the temporal evolution of the sequence in unprecedented detail, which will help to better understand the physical processes in a geothermal reservoir, potentially not only in the Basel case.ISSN:2169-9313ISSN:0148-0227ISSN:2169-935

Full-Waveform based methods for Microseismic Monitoring Operations: An Application to Natural and Induced Seismicity in the Hengill Geothermal Area, Iceland

Geothermal systems in the Hengill volcanic area, SW Iceland, started to be exploited for electrical power and heat production since the late 1960s. Today the two largest operating geothermal power plants are located at Nesjavellir and Hellisheiði. This area is a complex tectonic and geothermal site, located at the triple junction between the Reykjanes Peninsula (RP), the Western Volcanic Zone (WVZ), and the South Iceland Seismic Zone (SISZ). The region is seismically highly active with several thousand earthquakes located yearly. The origin of such earthquakes may be either natural or anthropogenic. The analysis of microseismicity can provide useful information on natural active processes in tectonic, geothermal and volcanic environments as well as on physical mechanisms governing induced events. Here, we investigate the microseismicity occurring in Hengill area, using a very dense broadband seismic monitoring network deployed in Hellisheiði since November 2018, and apply sophisticated full-waveform based method for detection and location. Improved locations and first characterization indicate that it is possible to identify different types of microseismic clusters, which are associated with either production/injection or the tectonic setting of the geothermal area.ISSN:1680-7340ISSN:1680-735