Effect of Rotation on a Gas Turbine Blade Internal Cooling System: Experimental Investigation

A detailed aerothermal characterization of an advanced leading edge (LE) cooling system has been performed by means of experimental measurements. Heat transfer coefficient distribution has been evaluated exploiting a steady-state technique using thermochromic liquid crystals (TLCs), while flow field has been investigated by means of particle image velocimetry (PIV). The geometry key features are the multiple impinging jets and the four rows of coolant extraction holes, and their mass flow rate distribution is representative of real engine working conditions. Tests have been performed in both static and rotating conditions, replicating a typical range of jet Reynolds number (Rej), from 10,000 to 40,000, and rotation number (Roj) up to 0.05. Different crossflow conditions (CR) have been used to simulate the three main blade regions (i.e., tip, mid, and hub). The aerothermal field turned out to be rather complex, but a good agreement between heat transfer coefficient and flow field measurement has been found. In particular, jet bending strongly depends on crossflow intensity, while rotation has a weak effect on both jet velocity core and area-averaged Nusselt number. Rotational effects increase for the lower crossflow tests. Heat transfer pattern shape has been found to be substantially Reynolds independen

The Effect of Programmable Tactile Displays on Spatial Learning Skills in Children and Adolescents of Different Visual Disability

Vision loss has severe impacts on physical, social and emotional well-being. The education of blind children poses issues as many scholar disciplines (e.g., geometry, mathematics) are normally taught by heavily relying on vision. Touch-based assistive technologies are potential tools to provide graphical contents to blind users, improving learning possibilities and social inclusion. Raised-lines drawings are still the golden standard, but stimuli cannot be reconfigured or adapted and the blind person constantly requires assistance. Although much research concerns technological development, little work concerned the assessment of programmable tactile graphics, in educative and rehabilitative contexts. Here we designed, on programmable tactile displays, tests aimed at assessing spatial memory skills and shapes recognition abilities. Tests involved a group of blind and a group of low vision children and adolescents in a four-week longitudinal schedule. After establishing subject-specific difficulty levels, we observed a significant enhancement of performance across sessions and for both groups. Learning effects were comparable to raised paper control tests: however, our setup required minimal external assistance. Overall, our results demonstrate that programmable maps are an effective way to display graphical contents in educative/rehabilitative contexts. They can be at least as effective as traditional paper tests yet providing superior flexibility and versatility

Crisis Behavior in Autism Spectrum Disorders: A Self-Organized Criticality Approach

The Autism Spectrum Disorder (ASD) represents a set of life-long disorders. In particular, subjects with ASD can display momentary behaviors of acute agitation and aggressiveness called crisis behaviors. These events are problematic for the subject and care providers but little is known about their occurrence, namely, possible relations among intensity, frequency, and duration. A group of ASD subjects (n=33) has been observed for 12 months reporting data on each crisis (n=1137 crises). Statistical analysis did not find significant results, while the relation between crisis duration and frequency showed a good fit to a "power law" curve, suggesting the application of Self-Organized Criticality (SOC) model. The SOC is used to describe natural phenomena as earthquakes, bank failures of rivers, mass extinctions, and other systems where a type of "catastrophic events" is necessary to maintain a critical equilibrium. In a sense, subjects at risk of crisis behavior seem to fit the same model as seismic zones at risk of earthquakes. The employment of the same strategies, as those successfully developed for known SOC systems, could lead to important insights for ASD management. Moreover, the SOC model offers possible interpretations of crisis behavior dynamics suggesting that they are unpredictable and, in a sense, necessary

Perceptual and Semantic Contributions to Repetition Priming of Environmental Sounds

Repetition of environmental sounds, like their visual counterparts, can facilitate behavior and modulate neural responses, exemplifying plasticity in how auditory objects are represented or accessed. It remains controversial whether such repetition priming/suppression involves solely plasticity based on acoustic features and/or also access to semantic features. To evaluate contributions of physical and semantic features in eliciting repetition-induced plasticity, the present functional magnetic resonance imaging (fMRI) study repeated either identical or different exemplars of the initially presented object; reasoning that identical exemplars share both physical and semantic features, whereas different exemplars share only semantic features. Participants performed a living/man-made categorization task while being scanned at 3T. Repeated stimuli of both types significantly facilitated reaction times versus initial presentations, demonstrating perceptual and semantic repetition priming. There was also repetition suppression of fMRI activity within overlapping temporal, premotor, and prefrontal regions of the auditory "what” pathway. Importantly, the magnitude of suppression effects was equivalent for both physically identical and semantically related exemplars. That the degree of repetition suppression was irrespective of whether or not both perceptual and semantic information was repeated is suggestive of a degree of acoustically independent semantic analysis in how object representations are maintained and retrieve

Visuospatial encoding deficits and compensatory strategies in schizophrenia revealed by eye movement analysis during a working memory task

Objective: To investigate scanpath abnormalities during the encoding of static stimuli in schizophrenia and their interaction with visuospatial working memory (VSWM) dysfunction. Methods: Outpatients with schizophrenia and control subjects were asked to encode a static pattern for subsequent recognition after a short delay. We measured the number of correct and incorrect choices. We also assessed the number and the distribution of fixations, the scanning time in specific regions of interest (ROIs) and the head movements during the encoding of the stimuli. The distributions of fixations and scanning time in definite ROIs during the discrimination of the correct pattern from the foils were also measured. Results: Patients recognised fewer correct patterns than controls. Correct trials in patients were characterised by a specific exploration of the central part of the stimulus during its presentation, whereas this feature was absent in incorrect trials. However, the scanning time and the numbers of fixations and head movements during encoding were similar in both groups and unrelated to recognition accuracy. In both groups, correct trials were associated with a selective exploration of the correct pattern amongst the six possibilities during recognition. Furthermore, patients gave more attention to incorrect patterns with a leftmost element identical to that of the correct response and also those approximating its global structure. Conclusion: Patients showed a VSWM deficit independent of oculomotor dysfunctions and head movements during encoding. Patients' correct trials were related to specific scanning during encoding and discrimination phases. Analysis of these patterns suggests that patients try to compensate for reduced VSWM ability by using specific encoding strategie

Altered functional brain connectivity in a non-clinical sample of young adults with attention-deficit/hyperactivity disorder

Attention-deficit/hyperactivity disorder (ADHD) is characterized by symptoms of inattention and hyperactivity/impulsivity that often persist in adulthood. There is a growing consensus that ADHD is associated with abnormal function of diffuse brain networks, but such alterations remain poorly characterized. Using resting-state functional magnetic resonance imaging, we characterized multivariate (complex network measures), bivariate (network-based statistic), and univariate (regional homogeneity) properties of brain networks in a non-clinical, drug-naive sample of high-functioning young men and women with ADHD (nine males, seven females) and a group of matched healthy controls. Data from our sample allowed the isolation of intrinsic functional connectivity alterations specific to ADHD diagnosis and symptoms that are not related to developmental delays, general cognitive dysfunction, or history of medication use. Multivariate results suggested that frontal, temporal, and occipital cortices were abnormally connected locally as well as with the rest of the brain in individuals with ADHD. Results from the network-based statistic support and extend multivariate results by isolating two brain networks comprising regions between which inter-regional connectivity was significantly altered in the ADHD group; namely, a frontal amygdala-occipital network and a frontal temporal-occipital network. Brain behavior correlations further highlighted the key role of altered orbitofrontal-temporal and frontal-amygdala connectivity for symptoms of inattention and hyperactivity/impulsivity. All univariate properties were similar between groups. Taken together, results from this study show that the diagnosis and the two main symptom dimensions of ADHD are related to altered intrinsic connectivity in orbitofrontal-temporal-occipital and fronto-amygdala-occipital networks. Accordingly, our findings highlight the importance of extending the conceptualization of ADHD beyond segregated fronto-striatal alterations

Dynamic interactions between anterior insula and anterior cingulate cortex link perceptual features and heart rate variability during movie viewing

AbstractThe dynamic integration of sensory and bodily signals is central to adaptive behaviour. Although the anterior cingulate cortex (ACC) and the anterior insular cortex (AIC) play key roles in this process, their context-dependent dynamic interactions remain unclear. Here, we studied the spectral features and interplay of these two brain regions using high-fidelity intracranial-EEG recordings from five patients (ACC: 13 contacts, AIC: 14 contacts) acquired during movie viewing with validation analyses performed on an independent resting intracranial-EEG dataset. ACC and AIC both showed a power peak and positive functional connectivity in the gamma (30–35 Hz) frequency while this power peak was absent in the resting data. We then used a neurobiologically informed computational model investigating dynamic effective connectivity asking how it linked to the movie’s perceptual (visual, audio) features and the viewer’s heart rate variability (HRV). Exteroceptive features related to effective connectivity of ACC highlighting its crucial role in processing ongoing sensory information. AIC connectivity was related to HRV and audio emphasising its core role in dynamically linking sensory and bodily signals. Our findings provide new evidence for complementary, yet dissociable, roles of neural dynamics between the ACC and the AIC in supporting brain-body interactions during an emotional experience

The EARTHCRUISERS project (EARTH CRUst Imagery for investigating SEismicity, volcanism and marine natural Resources in the Sicilian offshore)

The EARTHCRUISERS project was developed for the MIUR’s call “Progetti Premiali 2015” by the “Istituto Nazionale di Oceanografia e di Geofisica Sperimentale” (Trieste, Italy) in collaboration with the “Istituto Nazionale di Geofisica e Vulcanologia, Osservatorio Etneo” (Catania, Italy) and “Stazione Zoologica Anton Dohrn” (Naples, Italy). The main goals of the project are: (i) to identify and characterize the main crustal tectonic structures offshore Sicily and the Aeolian Islands, (ii) to better understand the geodynamic processes controlling seismicity and volcanism affecting this region, and (iii) to furnish a useful tool to estimate seismic, tsunamigenic and volcanic hazard in the highly populated coastal sectors. Furthermore, in order to contribute at the Blue Growth objectives, the project aims to analyze some relevant issues related to mineral prospecting offshore, such as the characterization of the hydrothermal systems in the Tyrrhenian Sea and the impact of the exploitation of oil and gas fields on the marine environment in the Sicily Channel. To achieve these objectives the acquisition of multibeam and sidescan sonar, multichannel seismic reflection, magnetic and gravimetric data is planned. Nearly 2500 km of multichannel seismic reflection lines will be acquired during the project in the Marsili Basin (Tyrrhenian Sea) and Mt. Etna offshore. This large amount of data will allow to: better understand the relationship between tectonics and evolution of volcanism; identify active faults and volcanic bodies; better constrain the seismostratigraphic and structural setting of the study areas, and investigate the eventual occurrence of unstable volcanic slopes which could lead to landslide and tsunami. Finally, the deployment offshore southeastern Sicily of a temporary Ocean Bottom Seismometer (OBS) network will carry out for monitoring the natural seismicity in the area of VEGA platform, the largest oil extraction site in Italian seas. Data collected will be used to study the eventual correlation between local seismicity and oil extractive activities.PublishedRome2T. Deformazione crostale attiv

Transcranial magnetic stimulation in obsessive-compulsive disorder: a focus on network mechanisms and state dependence

Background: Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that has shown promise as an adjunct treatment for the symptoms of Obsessive-Compulsive Disorder (OCD). Establishing a clear clinical role for TMS in the treatment of OCD is contingent upon evidence of significant efficacy and reliability in reducing symptoms. Objectives: We present the basic principles supporting the effects of TMS on brain activity with a focus on network-based theories of brain function. We discuss the promises and pitfalls of this technique as a means of modulating brain activity and reducing OCD symptoms. Methods: Synthesis of trends and critical perspective on the potential benefits and limitations of TMS interventions in OCD. Findings: Our critical synthesis suggests the need to better quantify the role of TMS in a clinical setting. The context in which the stimulation is performed, the neural principles supporting the effects of local stimulation on brain networks, and the heterogeneity of neuroanatomy are often overlooked in the clinical application of TMS. The lack of consideration of these factors may partly explain the variable efficacy of TMS interventions for OCD symptoms. Conclusions: Results from existing clinical studies and emerging knowledge about the effects of TMS on brain networks are encouraging but also highlight the need for further research into the use of TMS as a means of selectively normalising OCD brain network dynamics and reducing related symptoms. The combination of neuroimaging, computational modelling, and behavioural protocols known to engage brain networks affected by OCD has the potential to improve the precision and therapeutic efficacy of TMS interventions. The efficacy of this multimodal approach remains, however, to be established and its effective translation in clinical contexts presents technical and implementation challenges. Addressing these practical, scientific and technical issues is required to assess whether OCD can take its place alongside major depressive disorder as an indication for the use of TMS