Non-magnetic impurities and in-gap bound states in topological insulators

In-gap bound states induced by non-magnetic impurities in various dimensional topological insulators are investigated based on a modified Dirac model that considers quadratic corrections to the mass term. Their existence and features greatly rely on the potential form of the impurity as well as the dimensionality of the topological insulator. It is analytically proven that the impurity potential modeled by the delta function can induce the bound states in one dimension (1D), but not in two and three. For a single non-magnetic impurity with a general isotropic potential, formal solutions are obtained and further numerical calculations are performed. In particular, the in-gap bound states induced by a non-magnetic impurity with isotropic Gaussian potentials in two-dimensional (2D) and three-dimensional (3D) topological insulators are numerically investigated. Information on how many in-gap bound states can be trapped by a non-magnetic Gaussian impurity is presented for the parameters from a series of topologically non-trivial materials. © IOP Publishing Ltd and Deutsche Physikalische Gesellschaft.published_or_final_versio

Vacancy-induced bound states in topological insulators

We present an exact solution of a modified Dirac equation for topological insulator in the presence of a hole or vacancy to demonstrate that vacancies can induce bound states in the band gap of topological insulators. They arise due to the Z 2 classification of time-reversal invariant insulators. Coexistence of the in-gap bound states and the edge or surface states in topological insulators suggests that imperfections may affect transport properties of topological insulators via additional bound states near the system boundary. © 2011 American Physical Society.published_or_final_versio

Quadratic magnetic field dependence of magnetoelectric photocurrent

We experimentally study the spin and electric photocurrents excited by a linearly polarized light via direct interband transitions in an InGaAs/InAlAs quantum well. In the absence of a magnetic field, the linearly polarized light induces a pure spin current due to the spin-orbit coupling, which may be transformed into a measurable electric current by applying an in-plane magnetic field. The induced electric photocurrent is linear with the in-plane magnetic field. Here, we report a quadratic magnetic field dependence of the photocurrent in the presence of an additional perpendicular component of the magnetic field. We attribute the observation to the Hall effect of magnetoelectric photocurrent. © 2011 American Physical Society.published_or_final_versio

Robust iterative feedback tuning control of a compliant rehabilitation robot for repetitive ankle training

Robot-assisted rehabilitation offers benefits, such as repetitive, intensive, and task-specific training, as compared to traditional manual manipulation performed by physiotherapists. In this paper, a robust iterative feedback tuning (IFT) technique for repetitive training control of a compliant parallel ankle rehabilitation robot is presented. The robot employs four parallel intrinsically compliant pneumatic muscle actuators that mimic skeletal muscles for ankle's motion training. A multiple degrees-of-freedom normalized IFT technique is proposed to increase the controller robustness by obtaining an optimal value for the weighting factor and offering a method with learning capacity to achieve an optimum of the controller parameters. Experiments with human participants were conducted to investigate the robustness as well as to validate the performance of the proposed IFT technique. Results show that the normalized IFT scheme will achieve a better and better tracking performance during the robot repetitive control and provides more robustness to the system by adapting to various situations in robotic rehabilitation

Magnetoelectric photocurrent generated by direct interband transitions in InGaAs/InAlAs two-dimensional electron gas

We report the observation of magnetoelectric photocurrent generated via direct interband transitions in an InGaAs/InAlAs two-dimensional electron gas by a linearly polarized incident light. The electric current is proportional to the in-plane magnetic field, which unbalances the velocities of the photoexcited carriers with opposite spins and consequently generates the electric current from a hidden spin photocurrent. The spin photocurrent can be evaluated from the measured electric current, and the conversion coefficient of spin photocurrent to electric current is self-consistently estimated to be 10-3-10 -2 per Tesla. The observed light-polarization dependence of the electric current is well explained by a theoretical model which reveals the wave vector angle dependence of the photoexcited carrier density. © 2010 The American Physical Society.published_or_final_versio

A system framework for OKP product planning in a cloud-based design environment

Nowadays, one-of-a-kind (OKP) companies, which generally operate in an 'engineer-to-order' business mode, strive to deliver individualized products with quality to achieve customer satisfaction. Thus, an accurate and prompt analysis of customer requirements (CRs) in the early design stage is critical to its success. However, most OKP companies are small or medium-sized enterprises (SMEs). Due to the limited resources and low product planning budget, they often cannot obtain abundant CR information nor can they afford the expense of complicated planning process. To address these issues, a system framework is proposed in support of OKP product planning process in a cloud-based design (CBD) environment. The challenges and future market niches of OKP companies are presented. The comparison of typical distributed systems shows that CBD, which utilizes advanced information technologies and business model, has advantages in providing sufficient resources, decreasing product development time span for OKP companies in a cost-efficient way. This article describes the proposed system architecture, the business interaction process and the information communication among customers, designers and marketing analysts at the product planning stage. To validate the proposed framework, a prototype system module MyProduct is under development in the CBD environment with an illustrative example

Secondhand smoke (SHS) exposures: Workplace exposures, related perceptions of SHS risk, and reactions to smoking in catering workers in smoking and nonsmoking premises

Introduction: Smoke-free workplace legislation often exempts certain venues. Do smoking (exempted) and nonsmoking (nonexempted) catering premises' workers in Hong Kong report different perceptions of risk from and reactions to nearby smoking as well as actual exposure to secondhand smoke (SHS)? Methods: In a cross-sectional survey of 204 nonsmoking catering workers, those from 67 premises where smoking is allowed were compared with workers from 36 nonsmoking premises in Hong Kong on measures of perceptions of risk and behavioral responses to self-reported SHS exposure, plus independent exposure assessment using urinary cotinine. Results: Self-reported workplace SHS exposure prevalence was 57% (95% CI = 49%-65%) in premises prohibiting and 100% (95% CI = 92%-100%) in premises permitting smoking (p < .001). Workers in smoking-permitted premises perceived workplace air quality as poorer (odds ratio [OR] = 9.3, 95% CI = 4.2-20.9) with higher associated risks (OR = 3.7, 95% CI = 1.6-8.6) than workers in smoking-prohibited premises. Workers in smoking-prohibited premises were more bothered by (OR = 0.2, 95% CI = 0.1-0.5) and took more protective action to avoid SHS (OR = 0.2, 95% CI = 0.1-0.4) than workers in smoking-permitted premises. Nonwork exposure was negatively associated with being always bothered by nearby smoking (OR = 0.3, 95% CI = 0.1-0.9), discouraging nearby smoking (OR = 0.5, 95% CI = 0.2-1.1), and discouraging home smoking (OR = 0.4, 95% CI = 0.2-0.9). Urinary cotinine levels were inversely related to workers' avoidance behavior but positively related to their perceived exposure-related risks. Conclusions: Different workplace smoking restrictions predicted actual SHS exposure, exposure-related risk perception, and protective behaviors. Workers from smoking-permitted premises perceived greater SHS exposure-related risks but were more tolerant of these than workers in smoking-prohibited premises. This tolerance might indirectly increase both work and nonwork exposures. © The Author 2011. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved.postprin

A Feasibility Study of Robot-Assisted Ankle Training Triggered by Combination of SSVEP Recognition and Motion Characteristics

In order to inspire subjects exerting more energy and pay more attention to SSVEP-based ankle training, this study introduce motion intention detection both in the first half cycle of single trainings and at the beginning of the training. This study also propose a novel method to recognize motion intention of subjects through merging the motion characteristics of the ankle training into the identification of SSVEP signals. Five healthy subjects participate in the training, and all can accomplish the training with the success rate of more than 80%. The proposed hybrid method can increase success rate from 50% to 80% comparing with the identification of SSVEP signals

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue

The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria. The CD4(+) T cell response to pneumococcus is increasingly recognised as an important mediator of immunity that protects against invasive disease, with data suggesting a critical role for Th17 cells in mucosal clearance. By assessing CD4 T cell proliferative responses we demonstrate age-related sequestration of Th1 and Th17 CD4(+) T cells reactive to pneumococcal protein antigens within mucosal lymphoid tissue. CD25(hi) T cell depletion and utilisation of pneumococcal specific MHCII tetramers revealed the presence of antigen specific Tregs that utilised CTLA-4 and PDL-1 surface molecules to suppress these responses. The balance between mucosal effector and regulatory CD4(+) T cell immunity is likely to be critical to pneumococcal commensalism and the prevention of unwanted pathology associated with carriage. However, if dysregulated, such responses may render the host more susceptible to invasive pneumococcal infection and adversely affect the successful implementation of both polysaccharide-conjugate and novel protein-based pneumococcal vaccines

Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2

BACKGROUND: PC cell-derived growth factor (PCDGF), also called epithelin/granulin precursor (GEP), is an 88-kDa secreted glycoprotein with the ability to stimulate cell proliferation in an autocrine fashion. In addition, some studies indicated that PCDGF participated in invasion, metastasis and survival of cancer cells by regulating cell migration, adhesion and proliferation. Yet the effects of PCDGF on proliferation and invasion of ovarian cancer cells in vitro and the mechanisms by which PCDGF mediates biological behaviors of ovarian cancer have rarely been reported. In the present study we investigated whether and how PCDGF/GEP mediated cell proliferation and invasion in ovarian cancer. METHODS: PCDGF/GEP expression level in three human ovarian cancer cell lines of different invasion potential were detected by RT-PCR and western blot. Effects of inhibition of PCDGF expression on cell proliferation and invasion capability were determined by MTT assay and Boyden chamber assay. Expression levels of cyclin D1 and CDK4 and MMP-2 activity were evaluated in a pilot study. RESULTS: PCDGF mRNA and protein were expressed at a high level in SW626 and A2780 and at a low level in SKOV3. PCDGF expression level correlated well with malignant phenotype including proliferation and invasion in ovarian cancer cell lines. In addition, the proliferation rate and invasion index decreased after inhibition of PCDGF expression by antisense PCDGF cDNA transfection in SW626 and A2780. Furthermore expression of CyclinD1 and CDK4 were downregulated and MMP-2 was inactivated after PCDGF inhibition in the pilot study. CONCLUSION: PCDGF played an important role in stimulating proliferation and promoting invasion in ovarian cancer. Inhibition of PCDGF decreased proliferation and invasion capability through downregulation of cyclin D1 and CDK4 and inactivation of MMP-2. PCDGF could serve as a potential therapeutic target in ovarian cancer