Quality Scalability Compression on Single-Loop Solution in HEVC

This paper proposes a quality scalable extension design for the upcoming high efficiency video coding (HEVC) standard. In the proposed design, the single-loop decoder solution is extended into the proposed scalable scenario. A novel interlayer intra/interprediction is added to reduce the amount of bits representation by exploiting the correlation between coding layers. The experimental results indicate that the average Bjøntegaard delta rate decrease of 20.50% can be gained compared with the simulcast encoding. The proposed technique achieved 47.98% Bjøntegaard delta rate reduction compared with the scalable video coding extension of the H.264/AVC. Consequently, significant rate savings confirm that the proposed method achieves better performance

Exome Genotyping and Association Genetics of Quantitative Traits in a Clonally Tested Loblolly Pine Population (Pinus taeda L.)

Loblolly pine (Pinus taeda L.) is one of the most widely planted and commercially important forest tree species in the USA and worldwide. However, whole genome resequencing in loblolly pine is hampered by its size and complexity. Additionally, the genetics underlying quantitative traits of loblolly pine remains to be discovered. As a valid and more feasible alternative, entire exome sequencing was hence employed to identify the gene-associated single nucleotide polymorphisms (SNPs) and to genotype the 375 tress in a clonally tested loblolly pine population. Adaptive and growth traits were also measured and analyzed on this population. The exome capture efficiency was high. A total of 972,720 high quality SNPs were identified after filtering. We found that linkage disequilibrium (LD) decayed very rapidly within this population. Two main distinct clusters representing western and eastern parts of the loblolly pine range were demonstrated by the population structure analysis using unlinked SNPs. Under a relaxed filtering condition, over 2.8 million SNP markers were used to test for single locus associations, SNP-SNP interactions and correlation of individual heterozygosity with phenotypic traits. Genetic correlations between traits as well as geographical variation exist within this population. A total of 36 SNP-trait associations were found for specific leaf area (5 SNPs), branch angle (2), crown width (3), stem diameter (4), total height (9), carbon isotope discrimination (4), nitrogen concentration (2), and pitch canker resistance (7). Eleven SNP-SNP interactions were found to be associated with branch angle (1 SNP-SNP interaction), crown width (2), total height (2), carbon isotope discrimination (2), nitrogen concentration (1), and pitch canker resistance (3). Non-additive effects imposed by dominance and epistasis compose a large fraction of the genetic variance for the quantitative traits. Candidate genes that underlie these traits have a wide spectrum of functions. The obtained results demonstrated the efficiency of exome capture for genotyping species such as loblolly pine with a large and complex genome. Multiple effects that influence the performance of loblolly pines identified in this study provide great resources for understanding the genetic control of complex traits, and have potential value for breeding through maker assisted selection and genomic selection

Detecting the genetic basis of local adaptation in loblolly pine (Pinus taeda L.) using whole exome-wide genotyping and an integrative landscape genomics analysis approach

In the Southern United States, the widely distributed loblolly pine contributes greatly to lumber and pulp production, as well as providing many important ecosystem services. Climate change may affect the productivity and range of loblolly pine. Nevertheless, we have insufficient knowledge of the adaptive potential and the genetics underlying the adaptability of loblolly pine. To address this, we tested the association of 2.8 million whole exome-based single nucleotide polymorphisms (SNPs) with climate and geographic variables, including temperature, precipitation, latitude, longitude and elevation data. Using an integrative landscape genomics approach by combining multiple environmental association and outlier detection analyses, we identified 611 SNPs associated with 56 climate and geographic variables. Longitude, maximum temperature of the warm months and monthly precipitation associated with most SNPs, indicating their importance and complexity in shaping the genetic variation in loblolly pine. Functions of candidate genes related to terpenoid synthesis, pathogen defense, transcription factors and abiotic stress response. We provided evidence that environment-associated SNPs also composed the genetic structure of adaptive phenotypic traits including height, diameter, metabolite levels and expression of genes. Our study promotes understanding of the genetic basis of local adaptation in loblolly pine, and provides promising tools for selecting genotypes adapted to local environments in a changing climate

Modulation of hippocampal gamma oscillations by dopamine in heterozygous Reeler mice In vitro

The reelin haploinsufficient heterozygous reeler mouse (HRM), an animal model of schizophrenia, has altered mesolimbic dopaminergic pathways, shares similar neurochemical, and behavioral properties with the patients with schizophrenia. Dysfunctional neural circuitry with impaired gamma (γ) oscillation (30–80 Hz) has been implicated in abnormal cognition in patients with schizophrenia. However, the function of neural circuitry in terms of γ oscillation and its modulation by dopamine has not been reported in HRM. In this study, first, we recorded γ oscillations in CA3 from wide type (WT) mice and HRM hippocampal slices, and studied the effects of dopamine (DA) on γ oscillations. We found that there was no difference in γ power between WT mice and HRM and that dopamine increased γ power of WT mice but not HRM, suggesting that dopamine modulations of network oscillations in HRM are impaired. Second, we found that N-methyl-D-aspartate receptor (NMDAR) antagonist itself increased γ power and occluded DA-mediated enhancement of γ power in WT mice but partially restored DA modulation of γ oscillations in HRM. Third, inhibition of phosphoinositide 3-kinase (PI3K), a downstream molecule of NMDAR, increased γ power and blocked the effects of DA on γ oscillation in WT mice and had no significant effect on γ power but largely restored DA modulation of γ oscillations in HRM. Our results reveal that impaired DA function in HRM is associated with dysregulated NMDAR-PI3K signaling, a mechanism that may be relevant in the pathology of schizophrenia

Embeddable Advanced Sensors for Harsh Environment Sensing Applications

Research and development in advanced sensors with embedded monitoring capability have experienced significant growth in recent years, fueled by their broad applications in real-time measurement of a wide variety of physical, chemical, and biological quantities. Compared with conventional sensors with bulky assemblies, recent progress in 3D manufacturing technologies (e.g., ultrafast laser micromachining and additive manufacturing) has opened up a new avenue in one-step fabrication of assembly-freemicro devices in various materials as well as the development of compact, customized, and intricate smart structures/components. The merits of these advanced manufacturing techniques enable the integration of embeddable advanced sensors into smart structures and components for improved robustness, enriched functionality, enhanced intelligence, and unprecedented performance

Variations of Mid-Pacific Trough and Their Relations to the Asian-Pacific-North American Climate: Roles of Tropical Sea Surface Temperature and Arctic Sea Ice

The mid-Pacific trough (MPT), occurring in the upper troposphere during boreal summer, acts as an atmospheric bridge connecting the climate variations over Asia, the Pacific, and North America. The first (second) mode of empirical orthogonal function analysis of the MPT, which accounts for 20.3 (13.4) percent of the total variance, reflects a change in its intensity on the southwestern (northeastern) portion of the trough. Both modes are significantly correlated with the variability of tropical Pacific sea surface temperature (SST). Moreover, the first mode is affected by Atlantic SST via planetary waves that originate from the North Atlantic and propagate eastward across the Eurasian continent, and the second mode is influenced by the Arctic sea ice near the Bering Strait by triggering an equatorward wave train over the Northeast Pacific. A stronger MPT shown in the first mode is significantly linked to drier and warmer conditions in the Yangtze Basin, southern Japan, and northern U.S. and a wetter condition in South Asia and northern China, while a stronger MPT shown in the second mode is associated with drier and warmer southwestern U.S. In addition, an intensified MPT (no matter in the southwestern or the northeastern portion) corresponds to more tropical cyclones (TCs) over the western North Pacific (WNP) and less TCs over the eastern Pacific (EP) in summer, which is associated with MPT-induced ascending and descending motions over the WNP and the EP, respectively

Comparison of cellular changes in cavalier King Charles spaniel and mixed breed dogs with myxomatous mitral valve disease

Introduction: The aim of this study was to determine if there are differences in cellular changes in Cavalier King Charles spaniel (CKCS) myxomatous mitral valves compared to non-CKCS dogs. Animals: Cavalier King Charles spaniels (n = 6) and age-matched mixed breed (n = 6) with severe myxomatous mitral valve disease (MMVD), and normal mixed breed (n = 4) dogs. Materials and Methods: Immunohistochemistry staining and qualitative and quantitative analysis of mitral valves sections, examining for the presence of CD11c and CD45, vimentin, alpha smooth muscle actin (α-SMA) and embryonic smooth muscle myosin heavy chain (Smemb), von Willebrand factor and CD31 and Ki-67. Results: Vimentin positive cell numbers were increased in the MMVD dogs and distributed throughout the valve with greatest density close to the endothelium. There were no significant differences in cell marker expression for the two diseased groups, but cell numbers were significantly increased compared to controls for α-SMA (CKCS only) and Smemb (CKCS and mixed breed: p < 0.05). Alpha smooth muscle actin+ cells were primarily located at the valve edge, with Smemb+ cells similarly located, but also present throughout the valve stroma. A small number of cells close to the valve edge co-expressed α-SMA and Smemb. Endothelial von Willebrand factor expression was identified in all valves, with evidence of disrupted endothelium in the diseased, but was also found in diseased valve stroma. There was no staining for CD11c, CD45 or CD31 in any valve. Ki-67+ cells formed linear clusters at the leaflet tip and were sparsely distributed throughout both myxomatous valve groups. Conclusions: The cellular changes notes with advanced stage MMVD appear similar for CKCS when compared to mixed breed dogs