38,066 research outputs found
Phonon arithmetic in a trapped ion system
Single-quantum level operations are important tools to manipulate a quantum state. Annihilation or creation of single particles translates a quantum state to another by adding or subtracting a particle, depending on how many are already in the given state. The operations are probabilistic and the success rate has yet been low in their experimental realization. Here we experimentally demonstrate (near) deterministic addition and subtraction of a bosonic particle, in particular a phonon of ionic motion in a harmonic potential. We realize the operations by coupling phonons to an auxiliary two-level system and applying transitionless adiabatic passage. We show handy repetition of the operations on various initial states and demonstrate by the reconstruction of the density matrices that the operations preserve coherences. We observe the transformation of a classical state to a highly non-classical one and a Gaussian state to a non-Gaussian one by applying a sequence of operations deterministically
Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9
Duchenne muscular dystrophy (DMD) is a fatal, X-linked muscle wasting disease caused by mutations in the DMD gene. In 51% of DMD cases, a reading frame is disrupted because of deletion of several exons. Here, we show that CjCas9 derived from Campylobacter jejuni can be
used as a gene editing tool to correct an out-of-frame Dmd exon in Dmd knockout mice. Herein, we used Cas9 derived from S. pyogenes to generate Dmd knockout (KO) mice with a frameshift mutation in Dmd gene. Then, we expressed CjCas9, its single-guide RNA, and the eGFP gene
in the tibialis anterior muscle of the Dmd KO mice using an all-in-one adeno-associated virus (AAV) vector. CjCas9 cleaved the target site in the Dmd gene efficiently in vivo and induced small insertions or deletions at the target site. This treatment resulted in conversion of the
disrupted Dmd reading frame from out-of-frame to in-frame, leading to the expression of dystrophin in the sarcolemma. Importantly, muscle strength was enhanced in the CjCas9-treated muscles, without off-target mutations, indicating high efficiency and specificity of CjCas9. This work suggests that in vivo DMD frame correction, mediated by CjCas9 has great potential for the treatment of DMD and other neuromuscular diseases
Direct SUSY dark matter detection-Theoretical rates due to the spin
The recent WMAP data have confirmed that exotic dark matter together with the
vacuum energy (cosmological constant) dominate in the flat Universe. Thus the
direct dark matter detection, consisting of detecting the recoiling nucleus, is
central to particle physics and cosmology. Supersymmetry provides a natural
dark matter candidate, the lightest supersymmetric particle (LSP). The relevant
cross sections arise out of two mechanisms: i) The coherent mode, due to the
scalar interaction and ii) The spin contribution arising from the axial
current. In this paper we will focus on the spin contribution, which is
expected to dominate for light targets.
For both modes it is possible to obtain detectable rates, but in most models
the expected rates are much lower than the present experimental goals. So one
should exploit two characteristic signatures of the reaction, namely the
modulation effect and, in directional experiments, the correlation of the event
rates with the sun's motion.
In standard non directional experiments the modulation is small, less than
two per cent. In the case of the directional event rates we like to suggest
that the experiments exploit two features, of the process, which are
essentially independent of the SUSY model employed, namely: 1) The
forward-backward asymmetry, with respect to the sun's direction of motion, is
very large and 2) The modulation is much larger, especially if the observation
is made in a plane perpendicular to the sun's velocity. In this case the
difference between maximum and minimum can be larger than 40 per cent and the
phase of the Earth at the maximum is direction dependent.Comment: 16 Latex pages, 15 figures, 3 table
Superconducting Gap Anisotropy in NdCeCuO: Results from Photoemission
We have performed angle resolved photoelectron spectroscopy on the electron
doped cuprate superconductor NdCeCuO. A comparison of the
leading edge midpoints between the superconducting and normal states reveals a
small, but finite shift of 1.5-2 meV near the (,0) position, but no
observable shift along the zone diagonal near (/2,/2). This is
interpreted as evidence for an anisotropic superconducting gap in the electron
doped materials, which is consistent with the presence of d-wave
superconducting order in this cuprate superconductor.Comment: 5 pages, 4 figures, RevTex, to be published in Phys. Rev. Let
Anomalous high energy dispersion in photoemission spectra from insulating cuprates
Angle resolved photoelectron spectroscopic measurements have been performed
on an insulating cuprate Ca_2CuO_2Cl_2. High resolution data taken along the
\Gamma to (pi,pi) cut show an additional dispersive feature that merges with
the known dispersion of the lowest binding energy feature, which follows the
usual strongly renormalized dispersion of ~0.35 eV. This higher energy part
reveals a dispersion that is very close to the unrenormalized band predicted by
band theory. A transfer of spectral weight from the low energy feature to the
high energy feature is observed as the \Gamma point is approached. By comparing
with theoretical calculations the high energy feature observed here
demonstrates that the incoherent portion of the spectral function has
significant structure in momentum space due to the presence of various energy
scales.Comment: 5 pages, 3 figure
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Investigating the Solid-Liquid Phase Transition of Water Nanofilms Using the Generalized Replica Exchange Method
This is the author's accepted manuscript. The final version is available from AIP at http://scitation.aip.org/content/aip/journal/jcp/141/18/10.1063/1.4896513.The Generalized Replica Exchange Method (gREM) was applied to simulate a solid-liquid phase transition in a nanoconfined bilayer water system using the monatomic water (mW) model. Merging an optimally designed non-Boltzmann sampling weight with replica exchange, gREM is particularly well suited for the effective simulation of first-order phase transitions characterized by S-bends (“backbending”) in the statistical temperature and a bimodal structure in the canonical probability density function. The effective temperatures of gREM were designed to form unique crossing points with the statistical temperature, thereby facilitating sampling of energy states across the transition region. Statistical Temperature Weighted Histogram Analysis Method (ST-WHAM) was used to reweight gREM simulation results into canonical ensemble averages, including the Helmholtz free energy, internal energy, and heat capacity. The minimized structures of bilayer water systems with varying sizes were obtained through basin-hopping global optimization using the GMIN package, and ice structures composed of pentagons, hexagons and heptagons were observed
Charge-Transfer Excitations in the Model Superconductor HgBaCuO
We report a Cu -edge resonant inelastic x-ray scattering (RIXS) study of
charge-transfer excitations in the 2-8 eV range in the structurally simple
compound HgBaCuO at optimal doping ( K).
The spectra exhibit a significant dependence on the incident photon energy
which we carefully utilize to resolve a multiplet of weakly-dispersive ( eV) electron-hole excitations, including a mode at 2 eV. The observation
of this 2 eV excitation suggests the existence of a charge-transfer pseudogap
deep in the superconducting phase. Quite generally, our data demonstrate the
importance of exploring the incident photon energy dependence of the RIXS cross
section.Comment: 5 pages, 3 figure
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