Efficient Synthesis of Fluorescent Coumarins and Phosphorous-Containing Coumarin-Type Heterocycles via Palladium Catalyzed Cross-Coupling Reactions

Quantum-chemical calculations on the spectral properties of some aryl substituted 3- phosphonocoumarins were performed, and the effect of the substituents in the aryl moiety was evaluated. The structures possessing promising fluorescent properties were successfully synthesized via Suzuki and Sonogashira cross-coupling. The synthetic protocol was also applied for the phosphorous chemoisomer of 3-phosphonocoumarin, 1,2-benzoxaphosphorin, and their carboxylate analogues. The optical properties of the arylated and alkynylated products were experimentally determined. The obtained quantum-chemical and experimental results give the possibility for a fine tuning of the optical properties of phosphorous-containing coumarin systems by altering the substituent at its C-6 position

ACTIVAGE - D9.6 Final results report & sustainability plan (I to IX)

We have reached the end of a challenging and rewarding journey, after 45 months of ACTIVAGE, this is the last report that aims at providing a taste of the huge work done by the teams at the local sites. This is a testimony of the more than 45 partners that have participated in this WP. We started with 9 DS in 7 countries and we finish with 12 DS in 9 countries, having incorporated three new DS through the open call, and expanding ACTIVAGE vision and ecosystem to Portugal and Bulgaria. We have been able to reach the target of deploying AHA-IoT solutions for more than 7.200 users, we hit the mark of 7.776 and almost 97% of the expected deployments. All DS have been able to perform the evaluation, at local and global level, generating the evidence that ACTIVAGE vision is pertinent, relevant, and effective. Details are provided in the individual results and in D6.5. By the end of the project, still 80% of participants continue operation, and almost all DS have in place sustainability plans to continue providing ACTIVAGE services in one way or another. Even in the cases where no clear plans have been possible, there are opportunities for exploiting the services and the knowledge gained in the project