Optimization of refinery preheat trains: predictive maintenance and operations improvement

Deciding which heat exchanger to clean, when to clean and how to clean in refinery pre-heat trains is a challenging activity that typically relies on operator’s experience. In this paper, an algorithm that allow identifying the most economic cleaning schedule for a given refinery configuration and operating conditions is presented. The method relies on an advanced framework that incorporates rigorous heat exchanger models capable of predicting the fouling behaviour of the refinery as a function of configuration of the individual units and the network, process conditions and time. An industrial case study is presented to illustrate the benefits of the approach, showing that significant improvements over current practice can be obtained

CLA+ memory T cells in atopic dermatitis

Circulating skin‐homing cutaneous lymphocyte‐associated antigen (CLA)$^{+}$ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL‐13, IL‐31, pruritus, CCL17 and early effects on dupilumab‐treated patients have in common that they are associated with the CLA$^{+}$ T cell mechanisms in atopic dermatitis patients. The function of CLA$^{+}$ T cells corresponds with the role of T cells belonging to the skin‐associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology

Lectures on localization and matrix models in supersymmetric Chern-Simons-matter theories

In these lectures I give a pedagogical presentation of some of the recent progress in supersymmetric Chern-Simons-matter theories, coming from the use of localization and matrix model techniques. The goal is to provide a simple derivation of the exact interpolating function for the free energy of ABJM theory on the three-sphere, which implies in particular the N^{3/2} behavior at strong coupling. I explain in detail part of the background needed to understand this derivation, like holographic renormalization, localization of path integrals, and large N techniques in matrix modelsComment: 73 pages, 7 figures. v2: references and clarifications added, misprints corrected. v3: more references, clarifications, and corrections. v4: more corrections and clarifications, final version to appear in J. Phys.

Gaia Focused Product Release: A catalogue of sources around quasars to search for strongly lensed quasars

Context. Strongly lensed quasars are fundamental sources for cosmology. The Gaia space mission covers the entire sky with the unprecedented resolution of $0.18$" in the optical, making it an ideal instrument to search for gravitational lenses down to the limiting magnitude of 21. Nevertheless, the previous Gaia Data Releases are known to be incomplete for small angular separations such as those expected for most lenses. Aims. We present the Data Processing and Analysis Consortium GravLens pipeline, which was built to analyse all Gaia detections around quasars and to cluster them into sources, thus producing a catalogue of secondary sources around each quasar. We analysed the resulting catalogue to produce scores that indicate source configurations that are compatible with strongly lensed quasars. Methods. GravLens uses the DBSCAN unsupervised clustering algorithm to detect sources around quasars. The resulting catalogue of multiplets is then analysed with several methods to identify potential gravitational lenses. We developed and applied an outlier scoring method, a comparison between the average BP and RP spectra of the components, and we also used an extremely randomised tree algorithm. These methods produce scores to identify the most probable configurations and to establish a list of lens candidates. Results. We analysed the environment of 3 760 032 quasars. A total of 4 760 920 sources, including the quasars, were found within 6" of the quasar positions. This list is given in the Gaia archive. In 87\% of cases, the quasar remains a single source, and in 501 385 cases neighbouring sources were detected. We propose a list of 381 lensed candidates, of which we identified 49 as the most promising. Beyond these candidates, the associate tables in this Focused Product Release allow the entire community to explore the unique Gaia data for strong lensing studies further.Comment: 35 pages, 60 figures, accepted for publication by Astronomy and Astrophysic

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago

Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. Conclusions: After 100 years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception

Online integration of optimal cleaning scheduling and control of heat exchanger networks under fouling

Fouling mitigation is paramount to maintaining the reliable and efficient operation of a heat exchanger network (HEN). From the operational perspective, fouling can be mitigated by changing the flow distribution in the network (control actions), or performing periodic cleanings of the units (scheduling actions). Flow control and scheduling have usually been considered independently, ignoring their interaction. This paper presents an online methodology and implementation that integrates control and scheduling decisions for fouling mitigation in HEN, using first principle models of the heat exchangers subject to fouling. A multiloop NMPC/MHE scheme is proposed to estimate the current state of the HEN, and then define the optimal flow distribution and cleaning schedule over a moving horizon. It is shown that this online scheme reacts rapidly to disturbances and copes with model-plant mismatch by updating the model parameters at an appropriate frequency. The methodology is demonstrated on a real industrial case study involving crude oil fouling in the preheat train of a refinery. Application of the methodology shows that (i) significant economic benefits result relative to the actual historical operation, (ii) the online integration achieves a lower operating cost than that of the optimization of control or scheduling individually, (iii) the effect of disturbances is important and the scheme rejects them efficiently, (iv) updating the prediction models deals effectively with plant-model mismatch and process variability, and gives a sufficiently accurate representation of the underlying process, and (v) the computational effort required to solve all optimization problems is low and allows for the practical online implementation of the scheme

Stochastic modelling of sandstorms affecting the optimal operation and cleaning scheduling of air coolers in concentrated solar power plants

The operation performance of air-coolers in concentrated solar power plants decays due to particulate deposition on heat transfer surfaces. The deposition process can be seen as a stochastic phenomenon. A modelling approach is proposed to capture the uncertainty and the effect of extreme events, such as sandstorms, affecting the performance of plants located in dry places through dust or sand deposition on the air coolers. A case study of a concentrated solar power plant located in Dubai is analysed. Sandstorms generate acute and drastic fouling of the air coolers, and this is modelled as a stochastic process using historical aerosol dispersion data. Ten scenarios are generated by sampling the probability distribution of sandstorms occurrence and intensity. The optimal operation (cleaning schedule and airflow profiles) of the air coolers is established using Benders decomposition to solve the resulting large-scale mixed integer non-linear programming problem. The results of the stochastic scenarios demonstrate that substantial savings of $0.6 M -$ 2.7 M per year are achieved by the optimal operation. Cost is minimised by a combined reactive and proactive cleaning policy which accounts for the frequency, intensity and seasonal variability of sandstorms, in addition to the variability on local radiation and weather conditions

CLA+ memory T cells in atopic dermatitis: CLA+ T cells and atopic dermatitis

Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology