Convergence of a Boundary Integral Method for Water Waves

We prove nonlinear stability and convergence of certain boundary integral methods for time-dependent water waves in a two-dimensional, inviscid, irrotational, incompressible fluid, with or without surface tension. The methods are convergent as long as the underlying solution remains fairly regular (and a sign condition holds in the case without surface tension). Thus, numerical instabilities are ruled out even in a fully nonlinear regime. The analysis is based on delicate energy estimates, following a framework previously developed in the continuous case [Beale, Hou, and Lowengrub, Comm. Pure Appl. Math., 46 (1993), pp. 1269–1301]. No analyticity assumption is made for the physical solution. Our study indicates that the numerical methods must satisfy certain compatibility conditions in order to be stable. Violation of these conditions will lead to numerical instabilities. A breaking wave is calculated as an illustration

Selection in spatial stochastic models of cancer: Migration as a key modulator of fitness

<p>Abstract</p> <p>Background</p> <p>We study the selection dynamics in a heterogeneous spatial colony of cells. We use two spatial generalizations of the Moran process, which include cell divisions, death and migration. In the first model, migration is included explicitly as movement to a proximal location. In the second, migration is implicit, through the varied ability of cell types to place their offspring a distance away, in response to another cell's death.</p> <p>Results</p> <p>In both models, we find that migration has a direct positive impact on the ability of a single mutant cell to invade a pre-existing colony. Thus, a decrease in the growth potential can be compensated by an increase in cell migration. We further find that the neutral ridges (the set of all types with the invasion probability equal to that of the host cells) remain invariant under the increase of system size (for large system sizes), thus making the invasion probability a universal characteristic of the cells selection status. We find that repeated instances of large scale cell-death, such as might arise during therapeutic intervention or host response, strongly select for the migratory phenotype.</p> <p>Conclusions</p> <p>These models can help explain the many examples in the biological literature, where genes involved in cell's migratory and invasive machinery are also associated with increased cellular fitness, even though there is no known direct effect of these genes on the cellular reproduction. The models can also help to explain how chemotherapy may provide a selection mechanism for highly invasive phenotypes.</p> <p>Reviewers</p> <p>This article was reviewed by Marek Kimmel and Glenn Webb.</p

Quantum dot formation on a strain-patterned epitaxial thin film

We model the effect of substrate strain patterning on the self-assembly of quantum dots (QDs). When the surface energy is isotropic, we demonstrate that strain patterning via embedded substrate inclusions may result in ordered, self-organized QD arrays. However, for systems with strong cubic surface energy anisotropy, the same patterning does not readily lead to an ordered array of pyramids at long times. We conclude that the form of the surface energy anisotropy strongly influences the manner in which QDs self-assemble into regular arrays.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87827/2/133102_1.pd

Polymer-induced tubulation in lipid vesicles

A mechanism of extraction of tubular membranes from a lipid vesicle is presented. A concentration gradient of anchoring amphiphilic polymers generates tubes from bud-like vesicle protrusions. We explain this mechanism in the framework of the Canham-Helfrich model. The energy profile is analytically calculated and a tube with a fixed length, corresponding to an energy minimum, is obtained in a certain regime of parameters. Further, using a phase-field model, we corroborate these results numerically. We obtain the growth of tubes when a polymer source is added, and the bud-like shape after removal of the polymer source, in accordance with recent experimental results

Weak solutions to problems involving inviscid fluids

We consider an abstract functional-differential equation derived from the pressure-less Euler system with variable coefficients that includes several systems of partial differential equations arising in the fluid mechanics. Using the method of convex integration we show the existence of infinitely many weak solutions for prescribed initial data and kinetic energy