The tRNAscan-SE, snoscan and snoGPS web servers for the detection of tRNAs and snoRNAs

Transfer RNAs (tRNAs) and small nucleolar RNAs (snoRNAs) are two of the largest classes of non-protein-coding RNAs. Conventional gene finders that detect protein-coding genes do not find tRNA and snoRNA genes because they lack the codon structure and statistical signatures of protein-coding genes. Previously, we developed tRNAscan-SE, snoscan and snoGPS for the detection of tRNAs, methylation-guide snoRNAs and pseudouridylation-guide snoRNAs, respectively. tRNAscan-SE is routinely applied to completed genomes, resulting in the identification of thousands of tRNA genes. Snoscan has successfully detected methylation-guide snoRNAs in a variety of eukaryotes and archaea, and snoGPS has identified novel pseudouridylation-guide snoRNAs in yeast and mammals. Although these programs have been quite successful at RNA gene detection, their use has been limited by the need to install and configure the software packages on UNIX workstations. Here, we describe online implementations of these RNA detection tools that make these programs accessible to a wider range of research biologists. The tRNAscan-SE, snoscan and snoGPS servers are available at , and , respectively

Posttraumatic Growth in Students, Crime Survivors and Trauma Workers Exposed to Adversity

Generalised models of positive change following adversity do not fully account for differences in adjustment among populations who experience posttraumatic growth (PTG). The contributions of event intentionality, frequency of the adversity types, age at serious event, spirituality/religiousness, active coping, PTSD symptoms and social support were explored as predictors of PTG across three samples of university students (N = 101; Study 1), survivors of violent crime recruited from support services (N = 71; Study 2) and those working with survivors of adversity (N = 96; Study 3). The results of Study 1 revealed that age at serious event, active coping, PTSD symptoms and social support positively predicted PTG. Within Study 2, spirituality/religiousness, active coping and social support were the significant positive predictors of PTG. Finally in Study 3, spirituality/religiousness, active coping and social support were the significant positive predictors of PTG. Across all studies, event intentionality and frequency of adversity types did not determine PTG. These results indicate that while participants within each of the populations have the ability to experience PTG, different factors predicted whether PTG was observed. The findings offer greater insight into the multifarious nature of adjustment following adversity

Trauma characteristics and posttraumatic growth: The mediating role of avoidance coping, intrusive thoughts and social support

Objective: Previous research suggests trauma characteristics can impact on posttraumatic growth (PTG). The current study considers whether previously identified predictors of PTG may produce different outcomes dependent on the characteristics of the trauma experienced. Method: Active coping, avoidant coping, emotional coping, intrusive thoughts, social support and spirituality were examined as potential mediators of relationships between trauma characteristics (interpersonal trauma, number of trauma types and childhood trauma) and PTG. The responses of 268 adults exposed to multiple and wide-ranging stressors were used to generate three multiple mediation models. Results: Intrusive thoughts and social support exerted small but significant indirect effects in all three multiple mediation models. Avoidant coping mediated associations between the number of trauma types and PTG, and the relationship between childhood trauma to PTG. Conclusion: Relationships between trauma characteristics and PTG appear to be explained through the presence of avoidant coping strategies, intrusive thoughts and the individual’s social environment, which could be the focus of intervention efforts to promote positive change

Assessing victim risk in cases of violent crime

Purpose: There is a body of evidence that suggests a range of psychosocial characteristics demarcate certain adults to be at an elevated risk for victimisation. To this end, the aim of the current study was to examine consistency between one police force, and a corresponding victim support service based in England, in their assessment of level of risk faced by victims of violent crime. Methodology: This study explored matched data on 869 adult victims of violent crime gathered from these two key services in Preston, namely Lancashire Constabulary and Victim Support, from which a sub-group of comparable ‘domestic violence’ cases (n=211) were selected for further examination. Findings: Data analyses revealed methodological inconsistencies in the assessment of victimisation resulting in discrepancies for recorded levels of risk in domestic violence cases across these two agencies. Practical implications: These findings provide a compelling argument for developing a more uniformed approach to victim assessment and indicate a significant training need. Value: This paper highlights areas of good practice and forwards several recommendations for improved practice that emphasises the integration of empirical research conducted by psychologists to boost the validity and reliability of risk assessment approaches and tools used

Repeat Victimisation, Retraumatisation and Victim Vulnerability

Abstract: This study explores the contribution that traumatic experiences and psychological post-traumatic stress symptoms make to predicting subsequent revictimisation in a sample of violent crime victims. In addition, the timing of first trauma exposure was also explored. Fifty-four adult victims (27 male and 27 female) of police recorded violent crime were interviewed and their traumatic exposure history, trauma symptomology, age at first trauma exposure as well as psychological and psychosocial functioning were assessed. These victims were followed longitudinally and subsequent revictimisation between six and twelve months post index victimisation measured. A greater number of types of trauma exposure was related lower emotional stability, higher trauma symptomology and revictimisation. Those victims with childhood traumatic exposure reported more trauma symptomology exposure than those without prior exposure. The implications for law enforcement and victim services are discussed

Case of Nigeria-Acquired Human African Trypanosomiasis in United Kingdom, 2016.

Human African trypanosomiasis has not been reported in Nigeria since 2012. Nevertheless, limitations of current surveillance programs mean that undetected infections may persist. We report a recent case of stage 2 trypanosomiasis caused by Trypanosoma brucei gambiense acquired in Nigeria and imported into the United Kingdom

Evidence-based implementation practices applied to the intensive treatment of eating disorders: Summary of research and illustration of principles using a case example

Implementation of evidence‐based practices (EBPs) in intensive treatment settings poses a major challenge in the field of psychology. This is particularly true for eating disorder (ED) treatment, where multidisciplinary care is provided to a severe and complex patient population; almost no data exist concerning best practices in these settings. We summarize the research on EBP implementation science organized by existing frameworks and illustrate how these practices may be applied using a case example. We describe the recent successful implementation of EBPs in a community‐based intensive ED treatment network, which recently adapted and implemented transdiagnostic, empirically supported treatment for emotional disorders across its system of residential and day‐hospital programs. The research summary, implementation frameworks, and case example may inform future efforts to implement evidence‐based practice in intensive treatment settings.Published versio

Oxygen isotopic evidence for high‐magnitude, abrupt climatic events during the Lateglacial Interstadial in north‐west Europe:analysis of a lacustrine sequence from the site of Tirinie, Scottish Highlands

The Last Glacial to Interglacial Transition (LGIT) is a period of climatic instability. δ18O records are ideal for investigating the LGIT as this proxy responds rapidly to even minor climatic oscillations. Lacustrine carbonates offer the opportunity to investigate spatial diversity in patterns of climatic change during the LGIT but this requires the generation of δ18O records from a range of latitudinal and longitudinal settings. This study presents a coupled pollen and stable isotopic study of lacustrine carbonates spanning the Windermere Interstadial (the British equivalent of Greenland Interstadial 1, the Lateglacial Interstadial) from the site of Tirinie in the Scottish Highlands, a region where δ18O records are absent. The Interstadial is characterized by three δ18O peaks, warm intervals, and two δ18O declines, cold episodes, the timing of which is constrained by the presence of crypto-tephra. The landscape at Tirinie was highly responsive to these climatic oscillations as the sedimentary and pollen record respond to each isotopic shift. The paper concludes by highlighting that, across the British Isles, lacustrine δ18O records of the Interstadial have a consistent stratigraphy/structure, although the magnitude of the isotopic shifts is regionally variable. Potential causes of this variability are discussed

“I get knocked down, but I get up again” – A qualitative exploration of posttraumatic growth after multiple traumas

Theories of positive change following traumatic events, known as posttraumatic growth (PTG), posit that growth occurs in pre-determined domains. However, the domains in which growth occurs have largely been suggested from the results of studies which have looked at isolated traumatic events. The current paper has two aims: first, to explore whether looking for growth only in pre-determined domains limits opportunities to identify other changes that may occur; and second, to describe growth processes and outcomes in survivors of multiple, rather than single, traumatic events. Twenty-six semi-structured interviews analyzed with thematic analysis revealed two themes (outcomes of trauma and processing trauma) and seven subthemes (managing subsequent stressors, identity changes, co-existing positive and negative changes, trauma-related thoughts, control perceptions, spiritual challenges and social support and disclosure). Of these themes, the ability to handle subsequent stressors, identity changes and control perceptions, have not been previously reported in qualitative studies. More flexible conceptualizations of growth are needed to understand the nuances of positive change among survivors of multiple trauma types

Biomechanics of predator–prey arms race in lion, zebra, cheetah and impala

The fastest and most manoeuvrable terrestrial animals are found in savannah habitats, where predators chase and capture running prey. Hunt outcome and success rate are critical to survival, so both predator and prey should evolve to be faster and/or more manoeuvrable. Here we compare locomotor characteristics in two pursuit predator–prey pairs, lion–zebra and cheetah–impala, in their natural savannah habitat in Botswana. We show that although cheetahs and impalas were universally more athletic than lions and zebras in terms of speed, acceleration and turning, within each predator–prey pair, the predators had 20% higher muscle fibre power than prey, 37% greater acceleration and 72% greater deceleration capacity than their prey. We simulated hunt dynamics with these data and showed that hunts at lower speeds enable prey to use their maximum manoeuvring capacity and favour prey survival, and that the predator needs to be more athletic than its prey to sustain a viable success rate