Predicting Consumer Decisions to Adopt Mobile Commerce in Saudi Arabia

Developments in the field of wireless communications have enhanced the amount of people using mobile devices, which has also meant there has been significant growth in the mobile commerce arena. This research is centred on examining the variables that can estimate consumer intention to adopt m-commerce within the context of Saudi Arabia. The research develops and expands on the TAM (Technology Acceptance Model), and makes reference to a number of critical areas, namely financial cost, individual differences and trust, with information gathered from 574 individual smartphone users located in the Kingdom of Saudi Arabia (K.S.A.). The findings from this research are considered valuable for the fields of m-commerce, particularly when such organisations seek to devise and implement marketing strategies

Teachers’ Perceptions of Culturally Responsive Pedagogy’s Influence on Instructional Strategies

Urban high school literacy teachers are concerned with being prepared to teach incoming, culturally diverse ninth-grade students. More specifically, teachers have difficulty with implementing culturally responsive instructional strategies (CRIS) in urban high school literacy classrooms. The purpose of this qualitative case study was to explore the challenges of using CRIS in urban high school literacy classrooms. Vygotsky’s social constructivist theory was the conceptual framework that informed this study, suggesting that students learn, and teachers instruct based on social experiences in thinking and interpreting the world. The guiding research question was concerning how high school teachers apply CRIS to address the unique needs and challenges of urban high school literacy learners. The data collection involved a purposeful sample of 10 literacy teachers, observations, and semi-structured interviews. Data analysis included thematic color-coding to identify patterns and themes to answer the research questions. The findings revealed challenges in culturally specific vocabulary and dialect. The findings also revealed challenges in time constraints due to content matter scheduling and multiple learning styles in the classroom. The recommendation is to provide a three-day professional development workshop on implementing CRIS through the creation of an online manual and explanatory videos. This study promotes positive social change through teachers implementing instructional strategies that incorporate cultural sensitivity aimed at improving student success

Requirements for Point of Care Devices using Use Case Maps

Point of Care (PoC) testing (diagnosis) is a method for bringing medical laboratories to a patient’s home to conduct diagnostic tests so that the patient does not need to go to the doctor or laboratory in person. PoC testing reduces the burden on expensive laboratory setups and provides management of patient care in cost effective manner. The design and development of the PoC device and the associated infrastructure must be done with extreme rigor, as the PoC system meets the definition of a mission critical or safety critical system. Requirements creation and management are the key processes for ensuring that a highly reliable and low defect PoC system is developed since accurate PoC testing-based diagnosis is an essential process improvement for remote patient care management. It is important that the requirements be specified accurately, completely and without any ambiguity so that the PoC device can be designed and developed with minimal errors. This provides physicians a vehicle to diagnose patients with drastically increased reliability. This paper explains how Use Case Maps (UCM), a modeling technique, can help to sufficiently model requirement specifications for a PoC system development. It illustrates PoC functional requirements and security requirements in terms of the UCM representation. DOI: 10.17762/ijritcc2321-8169.150616

Next-generation sequencing using microfluidic PCR enrichment for molecular autopsy.

BACKGROUND: We aimed to determine the mutation yield and clinical applicability of "molecular autopsy" following sudden arrhythmic death syndrome (SADS) by validating and utilizing low-cost high-throughput technologies: Fluidigm Access Array PCR-enrichment with Illumina HiSeq 2000 next generation sequencing (NGS). METHODS: We validated and optimized the NGS platform with a subset of 46 patients by comparison with Sanger sequencing of coding exons of major arrhythmia risk-genes (KCNQ1, KCNH2, SCN5A, KCNE1, KCNE2, RYR2). A combined large multi-ethnic international SADS cohort was sequenced utilizing the NGS platform to determine overall molecular yield; rare variants identified by NGS were subsequently reconfirmed by Sanger sequencing. RESULTS: The NGS platform demonstrated 100% sensitivity for pathogenic variants as well as 87.20% sensitivity and 99.99% specificity for all substitutions (optimization subset, n = 46). The positive predictive value (PPV) for NGS for rare substitutions was 16.0% (27 confirmed rare variants of 169 positive NGS calls in 151 additional cases). The overall molecular yield in 197 multi-ethnic SADS cases (mean age 22.6 ± 14.4 years, 68% male) was 5.1% (95% confidence interval 2.0-8.1%), representing 10 cases carrying pathogenic or likely pathogenic risk-mutations. CONCLUSIONS: Molecular autopsy with Fluidigm Access Array and Illumina HiSeq NGS utilizing a selected panel of LQTS/BrS and CPVT risk-genes offers moderate diagnostic yield, albeit requiring confirmatory Sanger-sequencing of mutational variants

The emerging structure of the Extended Evolutionary Synthesis: where does Evo-Devo fit in?

The Extended Evolutionary Synthesis (EES) debate is gaining ground in contemporary evolutionary biology. In parallel, a number of philosophical standpoints have emerged in an attempt to clarify what exactly is represented by the EES. For Massimo Pigliucci, we are in the wake of the newest instantiation of a persisting Kuhnian paradigm; in contrast, Telmo Pievani has contended that the transition to an EES could be best represented as a progressive reformation of a prior Lakatosian scientific research program, with the extension of its Neo-Darwinian core and the addition of a brand-new protective belt of assumptions and auxiliary hypotheses. Here, we argue that those philosophical vantage points are not the only ways to interpret what current proposals to ‘extend’ the Modern Synthesis-derived ‘standard evolutionary theory’ (SET) entail in terms of theoretical change in evolutionary biology. We specifically propose the image of the emergent EES as a vast network of models and interweaved representations that, instantiated in diverse practices, are connected and related in multiple ways. Under that assumption, the EES could be articulated around a paraconsistent network of evolutionary theories (including some elements of the SET), as well as models, practices and representation systems of contemporary evolutionary biology, with edges and nodes that change their position and centrality as a consequence of the co-construction and stabilization of facts and historical discussions revolving around the epistemic goals of this area of the life sciences. We then critically examine the purported structure of the EES—published by Laland and collaborators in 2015—in light of our own network-based proposal. Finally, we consider which epistemic units of Evo-Devo are present or still missing from the EES, in preparation for further analyses of the topic of explanatory integration in this conceptual framework

Survival Analysis Part I: Basic concepts and first analyses

Survival analysis is a collection of statistical procedures for data analysis where the outcome variable of interest is time until an event occurs. Because of censoring - the nonobservation of the event of interest after a period of follow-up - a proportion of the survival times of interest will often be unknown. It is assumed that those patients who are censored have the same survival prospects as those who continue to be followed, that is, the censoring is uninformative. Survival data are generally described and modelled in terms of two related functions, the survivor function and the hazard function. The survivor function represents the probability that an individual survives from the time of origin to some time beyond time t. It directly describes the survival experience of a study cohort, and is usually estimated by the KM method. The logrank test may be used to test for differences between survival curves for groups, such as treatment arms. The hazard function gives the instantaneous potential of having an event at a time, given survival up to that time. It is used primarily as a diagnostic tool or for specifying a mathematical model for survival analysis. In comparing treatments or prognostic groups in terms of survival, it is often necessary to adjust for patient-related factors that could potentially affect the survival time of a patient. Failure to adjust for confounders may result in spurious effects. Multivariate survival analysis, a form of multiple regression, provides a way of doing this adjustment, and is the subject the next paper in this series

Hierarchy Theory of Evolution and the Extended Evolutionary Synthesis: Some Epistemic Bridges, Some Conceptual Rifts

Contemporary evolutionary biology comprises a plural landscape of multiple co-existent conceptual frameworks and strenuous voices that disagree on the nature and scope of evolutionary theory. Since the mid-eighties, some of these conceptual frameworks have denounced the ontologies of the Modern Synthesis and of the updated Standard Theory of Evolution as unfinished or even flawed. In this paper, we analyze and compare two of those conceptual frameworks, namely Niles Eldredge’s Hierarchy Theory of Evolution (with its extended ontology of evolutionary entities) and the Extended Evolutionary Synthesis (with its proposal of an extended ontology of evolutionary processes), in an attempt to map some epistemic bridges (e.g. compatible views of causation; niche construction) and some conceptual rifts (e.g. extra-genetic inheritance; different perspectives on macroevolution; contrasting standpoints held in the “externalism–internalism” debate) that exist between them. This paper seeks to encourage theoretical, philosophical and historiographical discussions about pluralism or the possible unification of contemporary evolutionary biology