SETTING THE NETS

I started this project thinking that it was going to be about service learning that I have experienced throughout the last couple of years. As I have been writing I realize that this piece is about joy, love, fellowship, and most importantly, people. The last couple of years has showed me my passion for people and relationships help us on our journey for discovery of self

Hidden water: Salt Lake County, UT drainages, a part of the Western Waters Digital Library

presentatio

From subject selectors to college and interdisciplinary teams

posterThe renovation of the J .Willard Marriott Library, coupled with the changing responsibilities of public services librarians and the decreases in financial support, has forced librarians to evaluate their strategic alignment. The new Knowledge Commons has become the center for in-person reference and technical assistance. An Online Services unit addresses email and chat reference services along with research guides. The Digital Scholarship Lab focuses on data management, research projects involving the use of audio and video studios, usability testing, and new technologies as they become available. The traditional tasks of collection development and outreach to the subject departments became the responsibility of College and Interdisciplinary Teams or CITs. Public services librarians, therefore, had two organizational structures under which to work: task-focused and subject-oriented structures

Steps toward a Utah geospatial index

presentationGISAC Presentation February 14, 2009

Geospatial initiatives at the J. Willard Marriott Library

presentationSlideshow presentation given May 9th, 2012 at the UGIC conference held at Ruby's Inn, Bryce Canyon National Park. Presentation includes information on: A clickable county map of our digital assets. Hidden Water unveils surface water systems on the east side of the Salt Lake Valley. A collaboration with Utah Geological Survey to digitize and provide access to Geology thesis maps. Western Soundscapes offers thousands of recordings of Western animal species and their environments An historical GIS project with a faculty member in the Geography Department

Topiramate: Safety and Efficacy of Its Use in the Prevention and Treatment of Migraine

Migraine headaches are typically episodic in nature and may affect nearly 10% of the population. In addition to treatment, prevention of subsequent episodes or progression to a chronic migraine state is an important therapeutic area. Topiramate is a centrally acting medication approved for both the prevention of seizures and migraine headache. At this time, the exact mechanism of how topiramate assists in migraine prevention is unknown. Several large randomized, controlled trials have aided in establishing topiramate\u27s role in migraine prevention. Despite a favorable pharmacokinetic and adverse effect profile established in clinical trials, several additional studies, case reports and toxicology reports have demonstrated topiramate as a cause of cognitive and behavioural changes. The use of topiramate in migraine prevention can improve a patient\u27s quality of life and is a cost-effective option for migraine prevention

The role of speculative trade in market efficiency: Evidence from a betting exchange

Does speculative trade reduce mispricing and help create efficient markets or does it drive prices further from fundamentals? We analyze betting exchange trading on 9,562 UK horse races in 2013 and 2014 to find out. Crucially, as each race is run, the fundamental value of bets is unambiguously revealed. We find that the volume of trade is predictive of fundamentals, suggesting that speculative trade is on average conducive to market efficiency. However, much of this effect is concentrated in the in-running period during races when, even without trade, asset fundamentals would be revealed seconds later

LMTK3 confers chemo-resistance in breast cancer

Lemur tyrosine kinase 3 (LMTK3) is an oncogenic kinase that is involved in different types of cancer (breast, lung, gastric, colorectal) and biological processes including proliferation, invasion, migration, chromatin remodeling as well as innate and acquired endocrine resistance. However, the role of LMTK3 in response to cytotoxic chemotherapy has not been investigated thus far. Using both 2D and 3D tissue culture models, we found that overexpression of LMTK3 decreased the sensitivity of breast cancer cell lines to cytotoxic (doxorubicin) treatment. In a mouse model we showed that ectopic overexpression of LMTK3 decreases the efficacy of doxorubicin in reducing tumor growth. Interestingly, breast cancer cells overexpressing LMTK3 delayed the generation of double strand breaks (DSBs) after exposure to doxorubicin, as measured by the formation of γH2AX foci. This effect was at least partly mediated by decreased activity of ataxia-telangiectasia mutated kinase (ATM) as indicated by its reduced phosphorylation levels. In addition, our RNA-seq analyses showed that doxorubicin differentially regulated the expression of over 700 genes depending on LMTK3 protein expression levels. Furthermore, these genes were found to promote DNA repair, cell viability and tumorigenesis processes / pathways in LMTK3-overexpressing MCF7 cells. In human cancers, immunohistochemistry staining of LMTK3 in pre- and postchemotherapy breast tumor pairs from four separate clinical cohorts revealed a significant increase of LMTK3 following both doxorubicin and docetaxel based chemotherapy. In aggregate, our findings show for the first time a contribution of LMTK3 in cytotoxic drug resistance in breast cancer