Muon capture in nuclei: an ab initio approach based on quantum Monte Carlo methods

An ab initio quantum Monte Carlo method is introduced for calculating total rates of muon weak capture in light nuclei with mass number $A \leq 12$. As a first application of the method, we perform a calculation of the rate in $^4$He in a dynamical framework based on realistic two- and three-nucleon interactions and realistic nuclear charge-changing weak currents. The currents include one- and two-body terms induced by $\pi$- and $\rho$-meson exchange, and $N$-to-$\Delta$ excitation, and are constrained to reproduce the empirical value of the Gamow-Teller matrix element in tritium. We investigate the sensitivity of theoretical predictions to current parametrizations of the nucleon axial and induced pseudoscalar form factors as well as to two-body contributions in the weak currents. The large uncertainties in the measured values obtained from bubble-chamber experiments (carried out over 50 years ago) prevent us from drawing any definite conclusions.Comment: 6 pages, 1 figur

Muon Capture in Nuclei: An \u3ci\u3eab initio\u3c/i\u3e Approach Based on Green\u27s Function Monte Carlo Methods

An ab initio Green’s function Monte Carlo (GFMC) method is introduced for calculating total rates of muon weak capture in light nuclei with mass number A ≤ 12. As a first application of the method, we perform a calculation of the rate in 3H and 4He in a dynamical framework based on realistic two- and three-nucleon interactions and realistic nuclear charge-changing weak currents. The currents include one- and two-body terms induced by π-and ρ-meson exchange, and N-to-Δ excitation, and are constrained to reproduce the empirical value of the Gamow-Teller matrix element in tritium. We investigate the sensitivity of theoretical predictions to current parametrizations of the nucleon axial and induced pseudoscalar form factors as well as to two-body contributions in the weak currents. The large uncertainties in the measured 4He rates obtained from bubble-chamber experiments (carried out over 50 years ago) prevent us from drawing any definite conclusions. No data exist for 3H, but results are compared to those of a recent Faddeev calculation as a validation of the present GFMC method

Ab initio calculation of the electromagnetic and neutral-weak response functions of 4He and 12C

Precise measurement of neutrino oscillations, and hence the determination of their masses demands a quantitative understanding of neutrino-nucleus interactions. To this aim, two-body meson-exchange currents have to be accounted for along within realistic models of nuclear dynamics. We summarize our progresses towards the construction of a consistent framework, based on quantum Monte Carlo methods and on the spectral function approach, that can be exploited to accurately describe neutrino interactions with atomic nuclei over the broad kinematical region covered by neutrino experiments.Comment: 8 pages, 4 figure, Proceedings of the 21st International Conference on Few-Body Problems in Physics, Chicago, Illinois, US

Neutrino-nucleus cross section within the extended factorization scheme

The factorization scheme, based on the impulse approximation and the spectral function formalism, has been recently generalized to allow the description of electromagnetic nuclear interactions driven by two-nucleon currents. We have extended this framework to the case of weakly charged and neutral currents, and carried out calculations of the double-differential neutrino-carbon and neutrino-oxygen cross sections using two different models of the target spectral functions. The results, showing a moderate dependence on the input spectral function, confirm that our approach provides a consistent treatment of all reaction mechanisms contributing to the signals detected by accelerator-based neutrino experiments

Bimodal release ondansetron for acute gastroenteritis among adolescents and adults: A randomized clinical trial

Importance: Vomiting resulting from acute gastroenteritis is commonly treated with intravenous antiemetics in acute care settings. If oral treatment were beneficial, patients might not need intravenous administered hydration or medication. Furthermore, a long-acting treatment could provide sustained relief from nausea and vomiting. Objective: To determine whether an experimental long-acting bimodal release ondansetron tablet decreases gastroenteritis-related vomiting and eliminates the need for intravenous therapy for 24 hours after administration. Design, Setting, and Participants: This placebo-controlled, double-blind, randomized clinical trial included patients from 19 emergency departments and 2 urgent care centers in the United States from December 8, 2014, to February 17, 2017. Patients 12 years and older with at least 2 vomiting episodes from presumed gastroenteritis in the previous 4 hours and symptoms with less than 36 hours\u27 duration were randomized using a 3:2 active to placebo ratio. Analyses were performed on an intent-to-treat basis and conducted from June 1, 2017, to November 1, 2017. Intervention: Bimodal release ondansetron tablet containing 6 mg of immediate release ondansetron and 18 mg of a 24-hour release matrix for a total of 24 mg of ondansetron. Main Outcomes and Measures: Treatment success was defined as no further vomiting, no need for rescue medication, and no intravenous hydration for 24 hours after bimodal release ondansetron administration. Results: Analysis included 321 patients (mean [SD] age, 29.0 [11.1] years; 195 [60.7%] women), with 192 patients in the bimodal release ondansetron group and 129 patients in the placebo group. Treatment successes were observed in 126 patients in the bimodal release ondansetron group (65.6%) compared with 70 patients in the placebo group (54.3%), with an 11.4% (95% CI, 0.3%-22.4%) absolute probability difference. The proportion of treatment success was 21% higher among patients who received bimodal release ondansetron compared with those who received a placebo (relative risk, 1.21; 95% CI, 1.00-1.46; P = .04). In an analysis including only patients with a discharge diagnosis of acute gastroenteritis and no major protocol violations, there were 123 treatment successes (69.5%) in the bimodal release ondansetron group compared with 67 treatment successes (54.9%) in the placebo group (relative risk, 1.27; 95% CI, 1.05-1.53; P = .01). Adverse effects were infrequent and similar to the known safety profile of ondansetron. Conclusions and Relevance: This randomized clinical trial found that a long-acting bimodal release oral ondansetron tablet was an effective antiemetic among adolescents and adults with moderate to severe vomiting from acute gastroenteritis. The drug benefits extended to 24 hours after administration. Bimodal release ondansetron may decrease the need for intravenous access and emergency department care to manage acute gastroenteritis. Trial Registration: ClinicalTrials.gov identifier: NCT02246439

Ab Initio Calculation of the Electromagnetic and Neutral Weak Response Functions of \u3csup\u3e4\u3c/sup\u3eHe and \u3csup\u3e12\u3c/sup\u3eC

Precise measurement of neutrino oscillations, and hence the determination of their masses demands a quantitative understanding of neutrino-nucleus interactions. To this aim, two-body meson-exchange currents have to be accounted for along within realistic models of nuclear dynamics. We summarize our progresses towards the construction of a consistent framework, based on quantum Monte Carlo methods and on the spectral function approach, that can be exploited to accurately describe neutrino interactions with atomic nuclei over the broad kinematical region covered by neutrino experiments

Ocorrência e caracterização de bactérias isoladas de nódulos de amendoinzeiro (Arachis hypogaea L.) em solos paranaenses, Brasil.

RESUMO: O objetivo deste trabalho foi avaliar a ocorrência e caracterizar morfofisiologicamente e geneticamente bactérias isoladas de nódulos de amendoinzeiro (Arachis hypogaea L.), em solos paranaenses, Brasil. Em amostras de 36 municípios representativos do estado Paraná foi observada nodulação do amendoim em 84,4%, independente se em áreas cultivadas, ou em florestas. Nos testes de caracterização morfofisiológica de 44 estirpes autenticadas, 75% das estirpes apresentaram taxa de crescimento rápido em meio de cultura com manitol; 25 acidificaram o meio, cinco alcalinizaram e 14 não resultaram em modificação do pH. A capacidade de produzir sideróforos foi observada em 43% das estirpes e 16% foram capazes de solubilizar fosfato de cálcio em meio de cultura. O sequenciamento do gene 16S rRNA mostrou a formação de três principais grupos, correspondentes a três filos: Alfaproteobacteria, Betaproteobacteria e Firmicutes. O gênero com maior ocorrência foi o Bacillus