783 research outputs found
Ab initio calculation of the electromagnetic and neutral-weak response functions of 4He and 12C
Precise measurement of neutrino oscillations, and hence the determination of
their masses demands a quantitative understanding of neutrino-nucleus
interactions. To this aim, two-body meson-exchange currents have to be
accounted for along within realistic models of nuclear dynamics. We summarize
our progresses towards the construction of a consistent framework, based on
quantum Monte Carlo methods and on the spectral function approach, that can be
exploited to accurately describe neutrino interactions with atomic nuclei over
the broad kinematical region covered by neutrino experiments.Comment: 8 pages, 4 figure, Proceedings of the 21st International Conference
on Few-Body Problems in Physics, Chicago, Illinois, US
Local chiral interactions and magnetic structure of few-nucleon systems
The magnetic form factors of H, H, and He, deuteron
photodisintegration cross sections at low energies, and deuteron threshold
electrodisintegration cross sections at backward angles in a wide range of
momentum transfers, are calculated with the chiral two-nucleon (and
three-nucleon) interactions including intermediate states that have
recently been constructed in configuration space. The =3 wave
functions are obtained from hyperspherical-harmonics solutions of the
Schr\"odinger equation. The electromagnetic current includes one- and two-body
terms, the latter induced by one- and two-pion exchange (OPE and TPE,
respectively) mechanisms and contact interactions. The contributions associated
with intermediate states are only retained at the OPE level, and are
neglected in TPE loop (tree-level) corrections to two-body (three-body) current
operators. Expressions for these currents are derived and regularized in
configuration space for consistency with the interactions. The low-energy
constants that enter the contact few-nucleon systems. The predicted form
factors and deuteron electrodisintegration cross section are in excellent
agreement with experiment for momentum transfers up to 2--3 fm. However,
the experimental values for the deuteron photodisintegration cross section are
consistently underestimated by theory, unless use is made of the Siegert form
of the electric dipole transition operator. A complete analysis of the results
is provided, including the clarification of the origin of the aforementioned
discrepancy.Comment: 24 pages, 13 figure
Ab-initio Reaction Calculations for Carbon-12 (ESP Technical Report): ALCF-2 Early Science Program Technical Report
Report about the Ab-initio Reaction Calculations for Carbon-12 (ESP Technical Report): ALCF-2 Early Science Program Technical Repor
Rmcystatin3, a cysteine protease inhibitor from Rhipicephalus microplus hemocytes involved in immune response
The Rhipicephalus microplus tick is responsible for losses in the livestock production estimated in 2 billions USD. Despite its economical importance the knowledge in tick's physiology is sparse. in order to contribute to this scenario we describe the characterization of a cysteine proteinase inhibitor named Rmcystatin-3. Purified recombinant Rmcystatin-3 was able to inhibit cathepsin L (Ki = 2.5 nM), BmCl1 (Ki = 1.8 nM) and cathepsin B (Ki = 136 nM). Western blot and quantitative PCR analysis revealed the presence of Rmcystatin-3 in fat body, salivary gland but mainly in hemocytes. the mRNA levels of Rmcystatin-3 during bacterial challenge are drastically down-regulated. in order to define the Rmcystatin-3 possible role in tick immunity, the cystatin gene was knockdown by RNA interference with and without Escherichia coli infection. Our results showed that the Rmcystatin-3 silenced group was more immune competent to control bacterial infection than the group injected with non-related dsRNA. Taking together, our data strongly suggested an important role of Rmcystatin-3 in tick immunity. (C) 2014 Elsevier B.V. and Societe francaise de biochimie et biologie Moleculaire (SFBBM). All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento CientÃfico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de NÃvel Superior (CAPES)INCT-Entomologia Molecular, BrazilUniversidade Federal de São Paulo, Dept Biochem, Escola Paulista Med, BR-04044020 São Paulo, BrazilUniv Fed Rio Grande do Sul, Ctr Biotecnol Estado Rio Grande do Sul, Porto Alegre, RS, BrazilUniversidade Federal de São Paulo, Dept Biochem, Escola Paulista Med, BR-04044020 São Paulo, BrazilFAPESP: 05/03514-9FAPESP: 09/17589-1FAPESP: 12/03657-8Web of Scienc
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