Introduction

Peer reviewe

What's the future for heritage crime research?

Peer reviewe

Synergies of syntheses : a comparison of systematic review and scientific realist evaluation methods for crime prevention

This thesis makes two significant contributions to the advancement of knowledge within crime prevention. The first of these is to evaluate the success of repeat victimisation prevention interventions. Interventions across four crime types are assessed herein, and the context-mechanisms-outcome configurations examined. The second contribution of this thesis is to assess two techniques of meta-evaluation: systematic reviews and realist syntheses. Each of these techniques is used in turn to assess the repeat victimisation prevention interventions. The contribution of each technique to the knowledge pool is then discussed, and the question of whether they are complementary or contradictory approaches answered. The thesis is framed in the context of evolutionary epistemology, which is the philosophy underpinning both approaches to meta-evaluation addressed herein. The thesis starts, with an examination of: firstly, how the evaluation methods in question have evolved, and the background to their scientific worth; and secondly, how situational crime prevention measures have evolved over time. The thesis then examines the two competing approaches for their contribution to the evaluation ecosystem by using both to assess repeat victimisation prevention interventions. Finally, the last section poses the question of whether it is survival of the fittest, or whether co-existence or adaptation could be the key to survival for these two meta-evaluative methodologies. Repeat victimisation prevention is revealed as an effective way of reducing crime, with a need for further research to apply the principle across further crime types. A requirement is identified for a greater breadth and depth of information to be included in future crime prevention evaluations. The systematic review is shown to be a useful way of assessing the overall effectiveness of the interventions, whilst the realist synthesis fills in the detail of why some interventions work and others fail. It is concluded that both approaches to meta-evaluation have useful contributions to make, and that a third way incorporating the best elements from each method should be developed.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

‘The Rhino Horn on Display Has Been Replaced by a Replica’ : Museum Security in Finland and England

Museums are an integral part of the cultural life of societies. As well as having intangible value, many collections may also have considerable financial value and present a temptation to thieves. Furthermore, threats exist from accidents, natural disasters, and vandalism, among many other risks that have to be taken into account when building up museums security measures. In recent years, high-profile art thefts from museums and even, regrettably, acts of terror have drawn attention to the vulnerability of museum institutions as sites of crime and catastrophe. In particular, balancing visitor enjoyment and accessibility of the exhibits with security can be difficult for many. Despite awareness of these concerns, museums security remains to date under-represented in museological discourses, perhaps in part because of its perceived pragmatic nature. Another reason may be the difficulty of discussing in a meaningful way information that is often confidential and sensitive. In this paper, based on research carried out in Finland and England, we aim to analyse some of the key issues for museums security, which, whilst observed in northern European settings, also have relevance for museums globally. We set this discussion against the backdrop of ethical considerations and present our methodology for gathering the data and for discussing our results in a way which is both sensitive to confidentiality issues and still of use to the wider security, museums, and cultural heritage sectors.Peer reviewe

Belimumab : a technological advance for systemic lupus erythematosus patients? Report of a systematic review and meta-analysis

Objectives: To undertake a systematic review and meta-analysis to investigate clinical effectiveness of belimumab for patients with systemic lupus erythematosus (SLE) and antinuclear and/or anti-double-stranded DNA (dsDNA) autoantibodies. Methods: We searched eight electronic databases and reference lists for randomised controlled trials (RCTs) of belimumab against placebo or best supportive care. Quality assessment and random effects meta-analysis were undertaken. Design: A meta-analysis of RCTs. Participants: 2133 SLE patients. Primary and secondary outcome measures: SLE Responder Index (SRI) at week 52. Results: Three double-blind placebo-controlled RCTs (L02, BLISS-52 BLISS-76) investigated 2133 SLE patients. BLISS-52 and BLISS-76 trials recruited patients with antinuclear and/or anti-dsDNA autoantibodies and demonstrated belimumab effectiveness for the SRI at week 52. Ethnicity and geographical location of participants varied considerably between BLISS trials. Although tests for statistical heterogeneity were negative, BLISS-52 results were systematically more favourable for all measured outcomes. Meta-analysis of pooled 52-week SRI BLISS results showed benefit for belimumab (OR 1.63, 95% CI 1.27 to 2.09). By week 76, the primary SRI outcome in BLISS-76 was not statistically significant (OR 1.31, 95% CI 0.919 to 1.855)

Matched increases in cerebral artery shear stress, irrespective of stimulus, induce similar changes in extra-cranial arterial diameter in humans.

The mechanistic role of arterial shear stress in the regulation of cerebrovascular responses to physiological stimuli (exercise and hypercapnia) is poorly understood. We hypothesised that, if shear stress is a key regulator of arterial dilation, then matched increases in shear, induced by distinct physiological stimuli, would trigger similar dilation of the large extra-cranial arteries. Participants ( n = 10) participated in three 30-min experimental interventions, each separated by ≥48 h: (1) mild-hypercapnia (FICO2:∼0.045); (2) submaximal cycling (EX; 60%HRreserve); or (3) resting (time-matched control, CTRL). Blood flow, diameter, and shear rate were assessed (via Duplex ultrasound) in the internal carotid and vertebral arteries (ICA, VA) at baseline, during and following the interventions. Hypercapnia and EX produced similar elevations in blood flow and shear rate through the ICA and VA ( p < 0.001), which were both greater than CTRL. Vasodilation of ICA and VA diameter in response to hypercapnia (5.3 ± 0.8 and 4.4 ± 2.0%) and EX (4.7 ± 0.7 and 4.7 ± 2.2%) were similar, and greater than CTRL ( p < 0.001). Our findings indicate that matched levels of shear, irrespective of their driving stimulus, induce similar extra-cranial artery dilation. We demonstrate, for the first time in humans, an important mechanistic role for the endothelium in regulating cerebrovascular response to common physiological stimuli in vivo

The origins of nomadic pastoralism in the eastern Jordanian steppe: a combined stable isotope and chipped stone assessment

The circumstances in which domestic animals were first introduced to the arid regions of the southern Levant and the origins of nomadic pastoralism have been the subject of considerable debate. Nomadic pastoralism was a novel herd management practice with implications for the economic, social and cultural development of Neolithic communities inhabiting steppe and early village environs. Combining faunal stable isotope and chipped stone analyses from the eastern Jordanian Neolithic steppic sites of Wadi Jilat 13 and 25, and ‘Ain Ghazal in the Mediterranean agricultural zone of the Levantine Corridor, we provide a unique picture of the groups exploiting the arid areas