Potential harms of long-term acne treatment with oral antibiotics

Clinical Inquiries question: What are the potential harms of long-term acne treatment with oral antibiotics? Evidence-based answer: Specific evidence attributing adverse effects to long-term acne treatment with oral antibiotics is lacking. However, nausea, vomiting, or diarrhea are seen in 7% of patients taking tetracyclines, 4% taking macrolides, and 2% taking clindamycin. Tetracyclines also cause dizziness, headache, and photosensitivity in 2% of patients (strength of recommendation [SOR] A: based on meta-analyses of randomized controlled trials [RCTs]). In addition, tetracyclines are associated with rare hypersensitivity reactions (pneumonitis, eosinophilic nephritis, serum sickness) and intracranial hypertension (SOR C: based on case reports). Minocycline might increase the risk of systemic lupus erythematosus (SLE), autoimmune hepatitis, and polyarteritis nodosa, generally after 1 year of use (SOR B: based on retrospective cohort and case-control studies). Macrolides are associated with cardiac conduction abnormalities and, rarely, hepatotoxicity. Clindamycin is associated with pseudomembranous colitis (SOR C: based on case reports).Minh Dao, DO; Gary Kelsberg, MD; Diana Louden, MLibDr Dao is a resident family physician at the Valley Family Medicine Clinic in Renton, Wash. Dr Kelsberg is Deputy Editor of FPIN’s Clinical Inquiries and is part of the faculty at the Valley Family Medicine Clinic. Ms Louden is Life Sciences Librarian at the University of Washington in Seattle, Wash.Includes bibliographical reference

Transit Signatures of Inhomogeneous Clouds on Hot Jupiters: Insights From Microphysical Cloud Modeling

We determine the observability in transmission of inhomogeneous cloud cover on the limbs of hot Jupiters through post processing a general circulation model to include cloud distributions computed using a cloud microphysics model. We find that both the east and west limb often form clouds, but that the different properties of these clouds enhances the limb to limb differences compared to the clear case. Using JWST it should be possible to detect the presence of cloud inhomogeneities by comparing the shape of the transit lightcurve at multiple wavelengths because inhomogeneous clouds impart a characteristic, wavelength dependent signature. This method is statistically robust even with limited wavelength coverage, uncertainty on limb darkening coefficients, and imprecise transit times. We predict that the short wavelength slope varies strongly with temperature. The hot limb of the hottest planets form higher altitude clouds composed of smaller particles leading to a strong rayleigh slope. The near infrared spectral features of clouds are almost always detectable, even when no spectral slope is visible in the optical. In some of our models a spectral window between 5 and 9 microns can be used to probe through the clouds and detect chemical spectral features. Our cloud particle size distributions are not log-normal and differ from species to species. Using the area or mass weighted particle size significantly alters the relative strength of the cloud spectral features compared to using the predicted size distribution. Finally, the cloud content of a given planet is sensitive to a species' desorption energy and contact angle, two parameters that could be constrained experimentally in the future.Comment: 21 pages, 17 figures, submitted to ApJ, revised following comments from refere

MedGen: NCBI’s Portal to Information on Medical Conditions with a Genetic Component

MedGen serves as a portal to information on genetic aspects of human health and disease. Created and maintained by the National Center for Biotechnology Information (NCBI), it aggregates clinically-relevant content from both NCBI and non-NCBI databases. MedGen summaries and curated links are designed to be particularly useful to health care professionals considering genetic aspects of patient care

Rates of mother-to-child HIV transmission with new first-line antiretroviral therapies and associated viral suppression: updated systematic review and meta-regression

Search strategies for a systematic review; shared in conjunction with a PROSPERO protocol registration. Michelle Bulterys, Mike Barry, Maggie Walters, Diana Louden, Hmwe Kyu, Lynne Mofenson, Mary Mahy, Caitlin Dugdale, Kathleen Powis, Jeff Imai-Eaton. Rates of mother-to-child transmission of HIV with new first-line antiretroviral therapies and associated viral suppression: a protocol for the updated systematic review and meta-regression. PROSPERO 2024 CRD42024511011 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202451101

An Invitation for Informationists: Joining a Data Harmonization Research Project Already in Progress

Poster presented at Medical Libraries Association 2017Through an Administrative Supplement awarded by the National Institute on Aging, two librarians joined an Alzheimer’s disease research team to make the products of their data harmonization research more accessible and useful to the scientific community. Joining this team gave the librarians the opportunity to find practical ways to implement abstract principles like transparency, discoverability, and reproducibility. Here we make our data sharing framework more tangible by comparing research products to meals: If research is like cooking, sharing is like taking it to a potluckNational Institute on Agin

An Exploratory Classification Scheme of Health Sciences Disciplines: For use in bibliometric analyses of scholarly output

Classification Scheme of Health Sciences Discipline

Inclusion of Older Adults in Pharmacologic Randomized Controlled Clinical Trials of Autoimmune Rheumatic Diseases: A Systematic Review and Meta-analysis

Search strategies for a systematic review; shared in conjunction with a PROSPERO protocol registration. Sebastian E. Sattui, Namrata Singh, Jiha Lee, Sarah B. Lieber, Diana Louden, Didem Saygin, Rachael Stovall, Manuel Carpio-Tumba, Raisa Lomanto Silva, Lily Sung, Sneha Gupta, Laura C. Pedraza-Arévalo, Jeenah Gwak. Inclusion of Older Adults in Pharmacologic Randomized Controlled Clinical Trials of Autoimmune Rheumatic Diseases: A Systematic Review and Meta-analysis. PROSPERO 2023 CRD42023457996 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202345799

Quantifying Cross-Disciplinary Research in the Health Sciences: A Bibliometric Analysis Using Author Affiliations

Poster presentation from the FORCE 11 Conference in 2016Develop a bibliometric method to quantify cross-disciplinary research activity

Climate Justice for All: Climate Solutions Through an Equity Lens

POSTERS & CURATORS: Introduction - Climate Justice for All: Climate Solutions Through an Equity Lens [Kari Anderson] -- UN Climate Change Conference: COP at 26 [Kari Anderson] -- Climate Change and Indigenous Communities [Lynly Beard] -- Hot Cities: Climate Impacts on Communities of Color [Theresa Mudrock] -- Sikuvut Nunguliqtuq: Our Ice is Vanishing [Theresa Mudrock] -- “Nature’s Laboratory for Disaster” [Theresa Mudrock] -- Climate Change: Impact on Health [Carolyn Martin] -- Air Quality, Climate Change & Health: Identifying & Addressing Disparities [Diana Louden] -- Climate Grief: The Rising Tide of Eco-Anxiety [Kari Anderson] -- Climate Migration: In Search of a Habitable Home [Kari Anderson] -- Denial & Disinformation: How the Oil Industry Ignored the Science [Jessica Albano] -- Climate Coverage: How Norms & Bias Impact News [Jessica Albano] -- Editorial Cartoons: Perspectives on Climate Change [Calum Bryant] -- Beyond the Lorax: Children’s Books on the Environment [Theresa Mudrock] -- The Way Forward: Social & Political Solutions [Kari Anderson] -- The Way Forward: Science & Technology Solutions [Kari Anderson] -- Driven by Tribal Water Values: Strengthening Access to Sustainable Water in Partnership with the Akiak Native Community [Lynly Beard] -- Environmental Justice Programs: UWB/CC Community Reads [Hannah Mendro] -- Climate Justice & Sustainability: Student Groups at UW [Calum Bryant] -- What Will You Do to Reduce Your Carbon Footprint? [Jessica Albano]Climate Justice for All: Climate Solutions Through an Equity Lens was a poster exhibit held in the lobby of Allen Library North from 22 November 2021 to 31 January 2022. The exhibit explored many aspects of the climate change issue, with a focus on how it relates to equity and social justice