MicroRNA expression profiling showed that the retina of mice carrying a rhodopsin mutation that leads to retinitis pigmentosa have notably different microRNA profiles from wildtype mice; further in silico analyses identified potential retinal targets for differentially regulated microRNAs

Farrar, G Jane

Hokamp, Karsten

Humphries, Peter

Ivens, Alasdair C

Kenna, Paul F

Loscher, Carol J

Palfi, Arpad

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Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa

Arora

Arpad Palfi

Bartel

Care

Carol J. Loscher

Chan

Chang

G. Jane Farrar

Humphries

John

John H. Wilson

Karali

Karsten Hokamp

Kloosterman

Krek

Loscher

McNally

Palfi

Peter Humphries

Ryan

Sanyal

Tiansen Li

A common microRNA signature in mouse models of retinal degeneration

Copyright information:Taken from "Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa"http://genomebiology.com/2007/8/11/R248Genome Biology 2007;8(11):R248-R248.Published online 22 Nov 2007PMCID:PMC2258196. Bars represent deviations from mean expression levels for each microRNA (miR) on a logscale in c57 retina (dark blue), c57 brain (light blue), and mouse platform (magenta). Relative expression of some known retinal miRs. Relative expression of miRs with novel retinal specificity. Panels a and b display data from miR microarray experiments. Quantitative real-time reverse transcription polymerase chain reaction (qPCR) validation of expression of selected miRs. Note that columns are in descending order of difference between retinal and platform expression; y-axes are to different scales; and bars for miR-181a in brain and miR-204 in mouse platform are missing in panel a because of incomplete data

Alasdair C Ivens (42212)

Arpad Palfi (42214)

Carol J Loscher (42209)

G Jane Farrar (42215)

Karsten Hokamp (42210)

Paul F Kenna (42211)

Peter Humphries (42213)

The Francis Crick Institute

Comparative expression of selected miRs in the retina, brain, and mouse platform