Marine-derived n-3 fatty acids therapy for stroke

We thank the Cochrane Stroke Group, and in particular Hazel Fraser (Managing Editor) and Joshua Cheyne (Trials Search Coordinator and Information Specialist), for their support in the development of this protocol. CG Alvarez Campano is funded by the Mexican Council for Science and Technology (CONACyT) and the Institute of Innovation and Technology Transfer (I²T²) (grant number 457349).Peer reviewedPublisher PD

Regional variations in short stay urgent paediatric hospital admissions : a sequential mixed-methods approach exploring differences through data linkage and qualitative interviews

Acknowledgments We are grateful to Nobel Yuen and Michelle Chan for their help in calculating distance to hospital and to all the parents and NHS staff who participated Funding This work was supported by Chief Scientific Officer grant number HIPS 18-09Peer reviewedPublisher PD

Insights from and limitations of data linkage studies : analysis of short stay urgent admission referral source from routinely collected Scottish data

ACKNOWLEDGEMENTS The study was funded by the Chief Scientist Officer (HIPS/18/09). We are grateful for Dave Kelly at Albasoft for providing primary care data. We are grateful to Rebecca Fairnie at Electronic Data Research and Innovation Service for managing our access to all data.Peer reviewedPostprin

Identifying and prioritising future interventions with stakeholders to improve paediatric urgent care pathways in Scotland, UK : a mixed-methods study

Acknowledgments Amy Woodhouse of Children in Scotland registered charity critically reviewed and commented on drafts of this manuscript. We are grateful for Dave Kelly at Albasoft for providing primary care data. We are grateful to Rebecca Fairnie at Electronic Data Research and Innovation Service for managing our access to all data. The authors would like to extend our thanks to the parents and health professionals who participated in this study, and to the stakeholders who participated in both public and patient involvement activities and the engagement and prioritisation event. Funding :This work was supported by the Chief Scientist Office of the Scottish Government, grant number HIPS/18/09Peer reviewedPublisher PD

HIV infected adults do not have an excess of colonising bacteria in their large airways

BACKGROUND: HIV infected adults have increased susceptibility to bacterial pneumonia but the underlying immune defect is poorly understood. We tested the hypothesis that HIV infection might be associated with increased bacterial colonisation of distal airways by nasal flora, which would then predispose patients to bacterial pneumonia. METHODS: Healthy volunteer adults with normal chest radiographs were recruited. Bronchoscopy was carried out and uncontaminated mucosal samples were collected from proximal and distal sites in the large airways using a protected specimen brush. Samples were cultured to detect typical respiratory tract colonising organisms, and the proportion of samples found to contain colonising bacteria compared between HIV infected and uninfected subjects using non-parametric tests. RESULTS: Forty-nine subjects were studied of whom 27 were HIV infected. Colonising bacteria were identified in the nasopharynx of all subjects including Streptococcus pneumoniae in 6/49 subjects (5 HIV uninfected). Colonising bacteria were found in the distal airway of 6 subjects (3/27 HIV infected vs 3/22 HIV uninfected ; χ(2 )= 0.07, p = 0.8). Streptococcus pneumoniae was identified in the trachea of all subjects with nasal colonisation but in the distal airway of only 1 subject. CONCLUSIONS: There was no evidence to support a hypothesis of increased airway bacterial colonisation in healthy HIV infected subjects

Marine-derived n-3 fatty acids therapy for stroke

We thank the Cochrane Stroke Group, and in particular Hazel Fraser (Managing Editor) and Joshua Cheyne (Trials Search Coordinator and Information Specialist), for their support in the development of this protocol. CG Alvarez Campano is funded by the Mexican Council for Science and Technology (CONACyT) and the Institute of Innovation and Technology Transfer (I²T²) (grant number 457349).Peer reviewedPublisher PD

Adoption of e Infrastructure Services: inhibitors, enablers and opportunities

Based on more than 100 interviews with respondents from academic and IT services provider sides, we present findings from our study of inhibitors and enablers of adoption of e-Infrastructure services for research. We discuss issues raised and potential ways of addressing them