Regulation of desmocollin transcription in mouse preimplantation embryos

The molecular mechanisms regulating the biogenesis of the first desmosomes to form during mouse embryogenesis have been studied. A sensitive modification of a reverse transcriptase-cDNA amplification procedure has been used to detect transcripts of the desmosomal adhesive cadherin, desmocollin. Sequencing of cDNA amplification products confirmed that two splice variants, a and b, of the DSC2 gene are transcribed coordinately. Transcripts were identified in unfertilized eggs and cumulus cells and in cleavage stages up to the early 8-cell stage, were never detected in compact 8-cell embryos, but were evident again either from the 16-cell morula or very early blastocyst (approx 32-cells) stages onwards. These two phases of transcript detection indicate DSC2 is encoded by maternal and embryonic genomes. Previously, we have shown that desmocollin protein synthesis is undetectable in eggs and cleavage stages but initiates at the early blastocyst stage when desmocollin localises at, and appears to regulate assembly of, nascent desmosomes that form in the trophectoderm but not in the inner cell mass (Fleming, T. P., Garrod, D. R. and Elsmore, A. J. (1991), Development 112, 527–539). Maternal DSC2 mRNA is therefore not translated and presumably is inherited by blastomeres before complete degradation. Our results suggest, however, that initiation of embryonic DSC2 transcription regulates desmocollin protein expression and thereby desmosome formation. Moreover, data from blastocyst single cell analyses suggest that embryonic DSC2 transcription is specific to the trophectoderm lineage. Inhibition of E-cadherin-mediated cell-cell adhesion did not influence the timing of DSC2 embryonic transcription and protein expression. However, isolation and culture of inner cell masses induced an increase in the amount of DSC2 mRNA and protein detected. Taken together, these results suggest that the presence of a contact-free cell surface activates DSC2 transcription in the mouse early embryo. <br/

Asymmetric neutrino emission due to neutrino-nucleon scatterings in supernova magnetic fields

We derive the cross section of neutrino-nucleon scatterings in supernova magnetic fields, including weak-magnetism and recoil corrections. Since the weak interaction violates the parity, the scattering cross section asymmetrically depends on the directions of the neutrino momenta to the magnetic field; the origin of pulsar kicks may be explained by the mechanism. An asymmetric neutrino emission (a drift flux) due to neutrino-nucleon scatterings is absent at the leading level of $\mathcal O(\mu_BB/T)$, where $\mu_B$ is the nucleon magneton, $B$ is the magnetic field strength, and $T$ is the matter temperature at a neutrinosphere. This is because at this level the drift flux of the neutrinos are exactly canceled by that of the antineutrinos. Hence, the relevant asymmetry in the neutrino emission is suppressed by much smaller coefficient of $\mathcal O(\mu_BB/m)$, where $m$ is the nucleon mass; detailed form of the relevant drift flux is also derived from the scattering cross section, using a simple diffusion approximation. It appears that the asymmetric neutrino emission is too small to induce the observed pulsar kicks. However, we note the fact that the drift flux is proportional to the deviation of the neutrino distribution function from the value of thermal equilibrium at neutrinosphere. Since the deviation can be large for non-electron neutrinos, it is expected that there occurs cancellation between the deviation and the small suppression factor of $\mathcal O(\mu_BB/m)$. Using a simple parameterization, we show that the drift flux due to neutrino-nucleon scatterings may be comparable to the leading term due to beta processes with nucleons, which has been estimated to give a relevant kick velocity when the magnetic field is sufficiently strong as $10^{15}$--$10^{16}$ G.Comment: 19 pages, 1 figure. Accepted by Physical Review

Source population synthesis and the Galactic diffuse gamma-ray emission

Population synthesis is used to study the contribution from undetected sources to the Galactic ridge emission measured by EGRET. Synthesized source counts are compared with the 3rd EGRET catalogue at low and high latitudes. For pulsar-like populations, 5-10% of the emission >100 MeV comes from sources below the EGRET threshold. A steeper luminosity function can increase this to 20% without violating EGRET source statistics. Less luminous populations can produce much higher values without being detected. Since the unresolved source spectrum is different from the interstellar spectrum, it could provide an explanation of the observed MeV and GeV excesses above the predictions, and we give an explicit example of how this could work.Comment: Astrophysics and Space Science, in press. (Proceedings of Conference 'The multi-messenger approach to high-energy gamma-ray sources', Barcelona, 2006). Minor changes for accepted version, updated reference

On Hoyle-Narlikar-Wheeler mechanism of vibration energy powered magneto-dipole emission of neutron stars

We revisit the well-known Hoyle-Narlikar-Wheeler proposition that neutron star emerging in the magnetic-flux-conserving process of core-collapse supernova can convert the stored energy of Alfven vibrations into power of magneto-dipole radiation. We show that the necessary requirement for the energy conversion is the decay of internal magnetic field. In this case the loss of vibration energy of the star causes its vibration period, equal to period of pulsating emission, to lengthen at a rate proportional to the rate of magnetic field decay. These prediction of the model of vibration powered neutron star are discussed in juxtaposition with data on pulsating emission of magnetars whose radiative activity is generally associated with the decay of ultra strong magnetic field.Comment: Accepted for publication in Astrophysics & Space Scienc

Radio precursors to neutron star binary mergings

We discuss a possible generation of radio bursts preceding final stages of binary neutron star mergings which can be accompanied by short gamma-ray bursts. Detection of such bursts appear to be advantageous in the low-frequency radio band due to a time delay of ten to several hundred seconds required for radio signal to propagate in the ionized intergalactic medium. This delay makes it possible to use short gamma-ray burst alerts to promptly monitor specific regions on the sky by low-frequency radio facilities, especially by LOFAR. To estimate the strength of the radio signal, we assume a power-law dependence of the radio luminosity on the total energy release in a magnetically dominated outflow, as found in millisecond pulsars. Based on the planned LOFAR sensitivity at 120 MHz, we estimate that the LOFAR detection rate of such radio transients could be about several events per month from redshifts up to $z\sim1.3$ in the most optimistic scenario. The LOFAR ability to detect such events would crucially depend on exact efficiency of low-frequency radio emission mechanism.Comment: 6 pages, 2 figures, Accepted for publication in Astrophysics & Space Science. Largely extended version of ArXiv:0912.521

The Magnetic Field of the Solar Corona from Pulsar Observations

We present a novel experiment with the capacity to independently measure both the electron density and the magnetic field of the solar corona. We achieve this through measurement of the excess Faraday rotation due to propagation of the polarised emission from a number of pulsars through the magnetic field of the solar corona. This method yields independent measures of the integrated electron density, via dispersion of the pulsed signal and the magnetic field, via the amount of Faraday rotation. In principle this allows the determination of the integrated magnetic field through the solar corona along many lines of sight without any assumptions regarding the electron density distribution. We present a detection of an increase in the rotation measure of the pulsar J1801$-$2304 of approximately 160 \rad at an elongation of 0.95$^\circ$ from the centre of the solar disk. This corresponds to a lower limit of the magnetic field strength along this line of sight of $> 393\mu\mathrm{G}$. The lack of precision in the integrated electron density measurement restricts this result to a limit, but application of coronal plasma models can further constrain this to approximately 20mG, along a path passing 2.5 solar radii from the solar limb. Which is consistent with predictions obtained using extensions to the Source Surface models published by Wilcox Solar ObservatoryComment: 16 pages, 4 figures (1 colour): Submitted to Solar Physic

Can forest management based on natural disturbances maintain ecological resilience?

Given the increasingly global stresses on forests, many ecologists argue that managers must maintain ecological resilience: the capacity of ecosystems to absorb disturbances without undergoing fundamental change. In this review we ask: Can the emerging paradigm of natural-disturbance-based management (NDBM) maintain ecological resilience in managed forests? Applying resilience theory requires careful articulation of the ecosystem state under consideration, the disturbances and stresses that affect the persistence of possible alternative states, and the spatial and temporal scales of management relevance. Implementing NDBM while maintaining resilience means recognizing that (i) biodiversity is important for long-term ecosystem persistence, (ii) natural disturbances play a critical role as a generator of structural and compositional heterogeneity at multiple scales, and (iii) traditional management tends to produce forests more homogeneous than those disturbed naturally and increases the likelihood of unexpected catastrophic change by constraining variation of key environmental processes. NDBM may maintain resilience if silvicultural strategies retain the structures and processes that perpetuate desired states while reducing those that enhance resilience of undesirable states. Such strategies require an understanding of harvesting impacts on slow ecosystem processes, such as seed-bank or nutrient dynamics, which in the long term can lead to ecological surprises by altering the forest's capacity to reorganize after disturbance