A fatal case of autumn crocus (Colchicum autumnale) poisoning in a heifer: confirmation by mass-spectrometric colchicine detection

A heifer developed severe signs of acute gastrointestinal irritation 48 hr after ingesting fresh leaves of Colchicum autumnale growing on a damp meadow. Confirmation of the suspected toxicosis was obtained by detecting colchicine in serum and urine using liquid chromatography coupled with tandem mass spectrometry using atmospheric pressure chemical ionization. Although the serum colchicine concentration had declined to an apparently nontoxic level of 2.4 ng/ml, a more prominent concentration (640 ng/ml) indicative of colchicine poisoning was detected in the urine. This finding is consistent with the known toxicokinetic properties of colchicine, whereby a large volume of distribution results in low circulating blood concentrations and prolonged urinary excretion

INTOXICATION OF DOMESTIC AND WILD ANIMALS BY ANTICOAGULANT RODENTICIDES — A SYNTHESIS OF DATA FROM THE FRENCH NATIONAL VETERINARY ANTIPOISON CENTER

During the period from 1980 to 1985 the laboratory of toxicological analysis associated with the National Veterinary Antipoison Center received 1,343 samples for research of anticoagulant rodenticide (e.g., 14.1% of total samples): 79% concerned animals, 31% baits. Six compounds marketed in France were investigated (warfarin, chlorophacinone, bromadiolone, difenacoum, coumachlore, coumatetralyl). In two-thirds of the samples, none of these substances could be found. Warfarin was by far the most incriminated rodenticide (23.1%), and dogs represented the most affected species (65.7%). However, its occurrence decreases regularly. The other compounds were found with a very low frequency (1 to 3%). In 70% of the cases, baits were prepared with criminal intention of killing animals other than rodents

INTOXICATIONS PAR LA CHLOROPHACINONE (ETUDE EPIDEMIOLOGIQUE ET CLINIQUE D'APRES LES DONNEES DU C.N.I.T.V. LYON ET DU LABORATOIRE DE TOXICOLOGIE DE L'E.N.V.L. DE 1991 A 1996)

MARCY L'ETOILE-Ec.Nat.Vétéri (691272301) / SudocSudocFranceF

Les Intoxications des animaux domestiques (bilan du C.N.I.T.V. 1999)

LYON1-BU Santé (693882101) / SudocSudocFranceF

INTOXICATIONS DES CARNIVORES DOMESTIQUES PAR LES AINS A USAGE HUMAIN (ETUDE BIBLIOGRAPHIQUE ET EPIDEMIOLOGIQUE D'APRES LES DONNEES DU CNITV DE LYON ENTRE 1991 ET 1998)

MARCY L'ETOILE-Ec.Nat.Vétéri (691272301) / SudocSudocFranceF

INTOXICATIONS DES ANIMAUX DOMESTIQUES PAR LES PLANTES DE LA FAMILLE DES SOLANACEES

MARCY L'ETOILE-Ec.Nat.Vétéri (691272301) / SudocSudocFranceF

Les Intoxications des carnivores domestiques par les produits déclenchant l'assuétude

LYON1-BU Santé (693882101) / SudocSudocFranceF

Toxicite secondaire , en laboratoire, d'un rodenticide anticoagulant (bromadiolone) pour des predateurs de rongeurs champetres : buse variable (Buteo buteo) et hermine (Mustela erminea)

National audienc