12 loops and triple wrapping in ABJM theory from integrability

Adapting a method recently proposed by C. Marboe and D. Volin for ${\cal N}$=4 super-Yang-Mills, we develop an algorithm for a systematic weak coupling expansion of the spectrum of anomalous dimensions in the $sl(2)$-like sector of planar $\mathcal{N}$=6 super-Chern-Simons. The method relies on the Quantum Spectral Curve formulation of the problem and the expansion is written in terms of the interpolating function $h(\lambda)$, with coefficients expressible as combinations of Euler-Zagier sums with alternating signs. We present explicit results up to 12 loops (six nontrivial orders) for various twist L=1 and L=2 operators, corresponding to triple and double wrapping terms, respectively, which are beyond the reach of the Asymptotic Bethe Ansatz as well as L\"uscher's corrections. The algorithm works for generic values of L and S and in principle can be used to compute arbitrary orders of the weak coupling expansion. For the simplest operator with L=1 and spin S=1, the Pad\'e extrapolation of the 12-loop result nicely agrees with the available Thermodynamic Bethe Ansatz data in a relatively wide range of values of the coupling. A Mathematica notebook with a selection of results is attached.Comment: 31 pages, 1 figure. A Mathematica notebook with a selection of results is attached (please download the compressed file "Results.nb" listed under "Other formats"). v2: typos corrected; more precise checks of the results; an earlier incorrect version of the figure was replaced. Published in JHE

Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer

Small-cell lung cancer is the most aggressive type of lung cancer, characterized by a remarkable response to chemotherapy followed by development of resistance. Here, we describe SCLC subtypes in Mycl- and Nfib-driven GEMM that include CDH1-high peripheral primary tumor lesions and CDH1-negative, aggressive intrapulmonary metastases. Cisplatin treatment preferentially eliminates the latter, thus revealing a striking differential response. Using a combined transcriptomic and proteomic approach, we find a marked reduction in proliferation and metabolic rewiring following cisplatin treatment and present evidence for a distinctive metabolic and structural profile defining intrinsically resistant populations. This offers perspectives for effective combination therapies that might also hold promise for treating human SCLC, given the very similar response of both mouse and human SCLC to cisplatin

CopywriteR: DNA copy number detection from off-target sequence data.

Current methods for detection of copy number variants (CNV) and aberrations (CNA) from targeted sequencing data are based on the depth of coverage of captured exons. Accurate CNA determination is complicated by uneven genomic distribution and non-uniform capture efficiency of targeted exons. Here we present CopywriteR, which eludes these problems by exploiting 'off-target' sequence reads. CopywriteR allows for extracting uniformly distributed copy number information, can be used without reference, and can be applied to sequencing data obtained from various techniques including chromatin immunoprecipitation and target enrichment on small gene panels. CopywriteR outperforms existing methods and constitutes a widely applicable alternative to available tools

Exact Bremsstrahlung functions in ABJM theory

In this paper we study the Bremsstrahlung functions for the 1/6 BPS and the 1/2 BPS Wilson lines in ABJM theory. First we use a superconformal defect approach to prove a conjectured relation between the Bremsstrahlung functions associated to the geometric ($B^{\varphi}_{1/6}$) and R-symmetry ($B^{\theta}_{1/6}$) deformations of the 1/6 BPS Wilson line. This result, non-trivially following from a defect supersymmetric Ward identity, provides an exact expression for $B^{\theta}_{1/6}$ based on a known result for $B^{\varphi}_{1/6}$. Subsequently, we explore the consequences of this relation for the 1/2 BPS Wilson line and, using the localization result for the multiply wound Wilson loop, we provide an exact closed form for the corresponding Bremsstrahlung function. Interestingly, for the comparison with integrability, this expression appears particularly natural in terms of the conjectured interpolating function $h(\lambda)$. During the derivation of these results we analyze the protected defect supermultiplets associated to the broken symmetries, including their two- and three-point correlators.Comment: 43 pages, 3 figures. Minor changes. Published versio

Wilson lines as superconformal defects in ABJM theory: a formula for the emitted radiation

Abstract We study operator insertions into 1/2 BPS Wilson loops in N $$\mathcal{N}$$ = 6 ABJM theory and investigate their two-point correlators. In this framework, the energy emitted by a heavy moving probe can be exactly obtained from some two-point coefficients of bosonic and fermionic insertions. This allows us to confirm an early proposal [1] for computing the Bremsstrahlung function in terms of certain supersymmetric circular Wilson loops, whose value might be accessible to localization techniques. In the derivation of this result we also elucidate the structure of protected multiplets in the relevant superconformal defect theory and perform an explicit two-loop calculation