Calidad del servicio académico y satisfacción del apoderado en algunas instituciones educativas en el departamento de La Libertad - 2020

En un contexto donde la educación es relevante para el desarrollo del país, la calidad de enseñanza de las I.E. juega un papel preponderante, estas instituciones deben satisfacer holgadamente las necesidades y expectativas; es así que se presenta la investigación titulada “Calidad del servicio académico y satisfacción del apoderado de una Institución Educativa en el departamento de La Libertad - 2020, teniendo como objetivo determinar el nivel de relación entre la calidad del servicio académico y la satisfacción de los apoderados de una Institución Educativa en el departamento de La Libertad - 2020. Por ello, se realizó una investigación cuyo diseño fue descriptivo correlacional, con una muestra de 33 apoderados, utilizando como técnica la encuesta y como instrumento de investigación un cuestionario, para la confiabilidad de los instrumentos se usó el Alfa de Cronbach obteniéndose un valor de 0.853 y 0.853 respectivamente y para la validez se usó el juicio de expertos por contendido determinando la aplicabilidad. Al finalizar el estudio, se comprueba que existe relación significativa entre el nivel de calidad de servicio académico y la satisfacción del apoderado de una Institución Educativa en el departamento de La Libertad - 2020.In a context where education is relevant to the development of the country, the quality of teaching of the I.E. plays a preponderant role, these institutions must comfortably satisfy needs and expectations; Thus, the research entitled “Quality of academic service and satisfaction of the attorney-in-fact of an Educational Institution in the department of La Libertad - 2020 is presented, with the objective of determining the level of relationship between the quality of the academic service and the satisfaction of the attorneys-in-fact. of an Educational Institution in the department of La Libertad - 2020. Therefore, an investigation was carried out whose design was descriptive correlational, with a sample of 33 attorneys, using the survey as a technique and a questionnaire as a research instrument, for the reliability of For the instruments, Cronbach's Alpha was used, obtaining a value of 0.853 and 0.853 respectively, and for validity, the judgment of experts per content was used, determining the applicability. At the end of the study, it is verified that there is a significant relationship between the level of academic service quality and the satisfaction of the attorney-in-fact of an Educational Institution in the department of La Libertad - 2020

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

International audienc