Pilot3 D7.1 - Dissemination, communication and exploitation plan

This document is the Communication, Dissemination and Exploitation Plan (D7.1) of the Clean Sky 2 Innovation Action Pilot3. The document defines the communication and dissemination actions to be performed during the project, and the potential exploitation of the project results. A complete strategy of communication is presented, as well as the items and content already prepared for it

Dispatcher3 D7.1 - Project communication, dissemination and exploitation plan

This document is the Communication, Dissemination and Exploitation Plan (D7.1) of the Clean Sky 2 Innovation Action Dispatcher3. The document defines the communication and dissemination actions to be performed during the project, and the potential exploitation of the project results. A complete strategy of communication is presented, as well as the items and content already prepared for it

Risk Classification of Bladder Cancer by Gene Expression and Molecular Subtype

This study evaluated a panel including the molecular taxonomy subtype and the expression of 27 genes as a diagnostic tool to stratify bladder cancer patients at risk of aggressive behavior, using a well-characterized series of non-muscle invasive bladder cancer (NMIBC) as well as muscle-invasive bladder cancer (MIBC). The study was conducted using the novel NanoString nCounter gene expression analysis. This technology allowed us to identify the molecular subtype and to analyze the gene expression of 27 bladder-cancer-related genes selected through a recent literature search. The differential gene expression was correlated with clinicopathological variables, such as the molecular subtypes (luminal, basal, null/double negative), histological subtype (conventional urothelial carcinoma, or carcinoma with variant histology), clinical subtype (NMIBC and MIBC), tumor stage category (Ta, T1, and T2–4), tumor grade, PD-L1 expression (high vs. low expression), and clinical risk categories (low, intermediate, high and very high). The multivariate analysis of the 19 genes significant for cancer-specific survival in our cohort study series identified TP53 (p = 0.0001), CCND1 (p = 0.0001), MKI67 (p < 0.0001), and molecular subtype (p = 0.005) as independent predictors. A scoring system based on the molecular subtype and the gene expression signature of TP53, CCND1, or MKI67 was used for risk assessment. A score ranging from 0 (best prognosis) to 7 (worst prognosis) was obtained and used to stratify our patients into two (low [score 0–2] vs. high [score 3–7], model A) or three (low [score 0–2] vs. intermediate [score 3–4] vs. high [score 5–7], model B) risk categories with different survival characteristics. Mean cancer-specific survival was longer (122 + 2.7 months) in low-risk than intermediate-risk (79.4 + 9.4 months) or high-risk (6.2 + 0.9 months) categories (p < 0.0001; model A); and was longer (122 + 2.7 months) in low-risk than high-risk (58 + 8.3 months) (p < 0.0001; model B). In conclusion, the molecular risk assessment model, as reported here, might be used better to select the appropriate management for patients with bladder cancer

Dependence on the Identification of the Scale Energy Parameter Q 2 in the Quark Distribution Functions for a DIS Production of Za

We discuss the Z-production in a DIS (Deep Inelastic Scattering) process e + p → e + Z + X using the Parton Model, within the context of the Standard Model. In contrast with deep inelastic eP-scattering (e + p → e + X), where the choice of Q2, as the transferred momentum squared, is unambiguous; whereas in the case of boson production , the transferred momentum squared, at quark level, depends on the reaction mechanism (where is the EW interaction taking place). We suggest a proposal based on kinematics of the process considered and the usual criterion for Q2 , which leads to a simple and practical prescription to calculate Z-production via ep-DIS. We also introduce different options in order o perform the convolution of the parton distribution functions (PDFs) and the scattering amplitude of he quark processes. Our aim in this work is to analyze and show how large could be the dependence of the total cross section rates on different possible prescriptions used for the identification of the scale energy parameter Q2 . We present results for the total cross section as a function of the total energy √s of the system ep, in the range 300 &lt;√s ≤ 1300 Ge

Incidence of zygomycosis in transplant recipients

AbstractRecently, a remarkable increase in the incidence of zygomycosis has been reported from institutions in the USA and Europe. The use of voriconazole for the treatment of aspergillosis and, less frequently, the use of echinocandins as empirical treatment for invasive fungal infections are thought to be responsible for the increase. In addition, an increased incidence of this infection has been observed in transplant recipients, including both haematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) patients. There are no global surveys on the prevalence or incidence of zygomycosis, but data from individual institutions and countries show that zygomycosis is an emerging infection. The increased incidence of zygomycosis most probably reflects a greater frequency of predisposing factors, such as higher numbers of patients undergoing HSCT and immunosuppressive chemotherapy. In addition, the emergence of rare pathogens as a result of the rise in the use of antifungal therapy against common species can be postulated. Further, the availability of antifungal agents with activity profiles that are more specific for selected fungi increases the necessity of identifying pathogenic fungi; the frequency of Zygomycetes infections may have been underestimated until now because therapeutic decisions did not depend on the precise identification of pathogenic fungi

Temporal patterns in coral reef, seagrass and mangrove communities from Chengue bay CARICOMP site (Colombia): 1993-2008

Few monitoring programs have simultaneously assessed the dynamics of linked marine ecosystems (coral reefs, seagrass beds and mangroves) to document their temporal and spatial variability. Based on CARICOMP protocol we evaluated permanent stations in coral reefs, seagrass beds and mangroves from 1993 to 2008 in Chengue Bay at the Tayrona Natural Park, Colombian Caribbean. Overall, the studied ecosystems showed a remarkable stability pattern over the monitoring period. While there were annual variations in coral reefs (coral cover) and mangroves (litterfall) caused by hurricane Lenny in 1999, particular trends in seagrass (leaf area index and leaf productivity) appear to reflect the natural variability in this ecosystem. We suggest that monitoring sites at the three marine ecosystems had in general a healthy development in the last 16 years. Our results are critical to locally improve the management strategies (Tayrona Natural Park) and to understand the long-term dynamics of closely associated marine ecosystems in the Caribbean. Copyright © 2011 Elsevier B.V. All rights reserved

The importance of standard operating procedures in physical fitness assessment: a brief review

Background: Physical fitness status is a key aspect of health and, consequently, it is important to create and adopt appropriate interventions to maintain or improve it, and assess it using valid measures. While in other testing contexts, standard operating procedures (SOPs) are commonly and widely adopted, in physical fitness testing, a variety of unstandardized testing protocols are proposed. Aims: The topic of this review was to evaluate the existing literature on SOPs in physical fitness assessment and to provide guidelines on how SOPs could be created and adopted. Method: The electronic databases PubMed, Web of Science and Scopus were screened and original, peer-reviewed studies that included SOPs, related to physical fitness, were recorded. Results: After the inclusion and exclusion criteria screening, a total of six studies were included and these were critically and narratively analyzed. Conclusions: Standard operating procedures are rarely adopted in the field of physical fitness and a step by step guide has been provided in this manuscript. In the future, it is suggested to follow protocols as a routine, because this is the only way to generalize and contextualize findings

Humanitarian organizations' information practices : procedures and privacy concerns for serving the undocumented

Many humanitarian organizations in the United States work with the information of undocumented migrants to help them secure services that might otherwise be unattainable to them. Information and communication technologies can help their work, but can also significantly exacerbate the risks that undocumented individuals are facing, and expose them to security breakages, leaks, hacks, inadvertent disclosure, and courts requests. This study aims to provide a preliminary understanding of the information practices and systems that US humanitarian organizations employ to protect the privacy of the undocumented individuals they serve. To do so, we conducted interviews and an analysis of organizations' working documents within humanitarian organizations on the US West Coast, including advocacy groups and organizations with ties to higher education. Our outcomes show gaps between current legal standards, technology best practices, and the day‐to‐day functioning of the organizations. We contend the necessity of support to humanitarian organizations in further developing standards and training for digital privacy

The LSM1-7 Complex Differentially Regulates Arabidopsis Tolerance to Abiotic Stress Conditions by Promoting Selective mRNA Decapping

This work was supported by Grants BIO2010-17545 and BIO2013-47788-R from MINECO to J.S., GA14-34792S from CSFtoO.N., andMCB-1022435 fromtheNationalScience Foundation to L.S. R.C. is supported by a JAE-DOCcontract fromtheCSIC, andC.C.-L. is a recipient of a FPI fellowship from MINECO.International audienceIn eukaryotes, the decapping machinery is highly conserved and plays an essential role in controlling mRNA stability, a key step in the regulation of gene expression. Yet, the role of mRNA decapping in shaping gene expression profiles in response to environmental cues and the operating molecular mechanisms are poorly understood. Here, we provide genetic and molecular evidence that a component of the decapping machinery, the LSM1-7 complex, plays a critical role in plant tolerance to abiotic stresses. Our results demonstrate that, depending on the stress, the complex from Arabidopsis thaliana interacts with different selected stress-inducible transcripts targeting them for decapping and subsequent degradation. This interaction ensures the correct turnover of the target transcripts and, consequently, the appropriate patterns of downstream stress-responsive gene expression that are required for plant adaptation. Remarkably, among the selected target transcripts of the LSM1-7 complex are those encoding NCED3 and NCED5, two key enzymes in abscisic acid (ABA) biosynthesis. We demonstrate that the complex modulates ABA levels in Arabidopsis exposed to cold and high salt by differentially controlling NCED3 and NCED5 mRNA turnover, which represents a new layer of regulation in ABA biosynthesis in response to abiotic stress. Our findings uncover an unanticipated functional plasticity of the mRNA decapping machinery to modulate the relationship between plants and their environment