2,509 research outputs found
The CAR‐HEMATOTOX score identifies patients at high risk for hematological toxicity, infectious complications, and poor treatment outcomes following brexucabtagene autoleucel for relapsed or refractory MCL
CD19-directed CAR T-cell therapy with brexucabtagene autoleucel (brexu-cel) has substantially improved treatment outcomes for patients with relapsed/refractory mantle cell lymphoma (r/r MCL). Prolonged cytopenias and infections represent common and clinically relevant side effects. In this multicenter observational study, we describe cytopenias and infections in 103 r/r MCL patients receiving brexu-cel. Furthermore, we report associations between the baseline CAR-HEMATOTOX (HT) score and toxicity events, non-relapse mortality (NRM), and progression-free/overall survival (PFS/OS). At lymphodepletion, 56 patients were HTlow (score 0–1) while 47 patients were HThigh (score ≥2). The HThigh cohort exhibited prolonged neutropenia (median 14 vs. 6 days, p < .001) and an increased rate of severe infections (30% vs. 5%, p = .001). Overall, 1-year NRM was 10.4%, primarily attributed to infections, and differed by baseline HT score (high vs. low: 17% vs. 4.6%, p = .04). HThigh patients experienced inferior 90-day complete response rate (68% vs. 93%, p = .002), PFS (median 9 months vs. not-reached, p < .0001), and OS (median 26 months vs. not-reached, p < .0001). Multivariable analyses showed that high HT scores were independently associated with severe hematotoxicity, infections, and poor PFS/OS. In conclusion, infections and hematotoxicity are common after brexu-cel and contribute to NRM. The baseline HT score identified patients at increased risk of poor treatment outcomes
Coastal upwelling in the Rias Bajas, NW Spain: Contrasting the benthic regimes of the Rias de Arosa and de Muros
Nutrient-rich North Atlantic water upwells off the NW coast of Spain and intermittently intrudes into the rias, coastal embayments, by displacement during periods of offshore winds. High primary production associated with the upwelling supports an intensive raft culture of the edible mussel, Mytilus edulis. This culture is most intensive (ca. 2000 rafts) in the Ria de Arosa, and results in one of the highest protein yields per unit area on earth...
COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey
Altres ajuts: British Society for Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT); UK NIHR Imperial College Biomedical Research Centre.This study reports on 382 COVID-19 patients having undergone allogeneic (n = 236) or autologous (n = 146) hematopoietic cell transplantation (HCT) reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH). The median age was 54.1 years (1.0-80.3) for allogeneic, and 60.6 years (7.7-81.6) for autologous HCT patients. The median time from HCT to COVID-19 was 15.8 months (0.2-292.7) in allogeneic and 24.6 months (−0.9 to 350.3) in autologous recipients. 83.5% developed lower respiratory tract disease and 22.5% were admitted to an ICU. Overall survival at 6 weeks from diagnosis was 77.9% and 72.1% in allogeneic and autologous recipients, respectively. Children had a survival of 93.4%. In multivariate analysis, older age (p = 0.02), need for ICU (p < 0.0001) and moderate/high immunodeficiency index (p = 0.04) increased the risk while better performance status (p = 0.001) decreased the risk for mortality. Other factors such as underlying diagnosis, time from HCT, GVHD, or ongoing immunosuppression did not significantly impact overall survival. We conclude that HCT patients are at high risk of developing LRTD, require admission to ICU, and have increased mortality in COVID-19
Disappearance of back-to-back high hadron correlations in central Au+Au collisions at = 200 GeV
Azimuthal correlations for large transverse momentum charged hadrons have
been measured over a wide pseudo-rapidity range and full azimuth in Au+Au and
p+p collisions at = 200 GeV. The small-angle correlations
observed in p+p collisions and at all centralities of Au+Au collisions are
characteristic of hard-scattering processes already observed in elementary
collisions. A strong back-to-back correlation exists for p+p and peripheral Au
+ Au. In contrast, the back-to-back correlations are reduced considerably in
the most central Au+Au collisions, indicating substantial interaction as the
hard-scattered partons or their fragmentation products traverse the medium.Comment: submitted to Phys. Rev. Let
Production of Pairs Accompanied by Nuclear Dissociation in Ultra-Peripheral Heavy Ion Collision
We present the first data on pair production accompanied by nuclear
breakup in ultra-peripheral gold-gold collisions at a center of mass energy of
200 GeV per nucleon pair. The nuclear breakup requirement selects events at
small impact parameters, where higher-order corrections to the pair production
cross section should be enhanced. We compare the pair kinematic distributions
with two calculations: one based on the equivalent photon approximation, and
the other using lowest-order quantum electrodynamics (QED); the latter includes
the photon virtuality. The cross section, pair mass, rapidity and angular
distributions are in good agreement with both calculations. The pair transverse
momentum, , spectrum agrees with the QED calculation, but not with the
equivalent photon approach. We set limits on higher-order contributions to the
cross section. The and spectra are similar, with no evidence
for interference effects due to higher-order diagrams.Comment: 6 pages with 3 figures Slightly modified version that will appear in
Phys. Rev.
Rapidity and centrality dependence of proton and antiproton production from 197Au + 197Au collisions at √SNN = 130 GeV
We report on the rapidity and centrality dependence of proton and antiproton transverse mass distributions from 197Au + 197Au collisions at sqrt[sNN ]=130 GeV as measured by the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). Our results are from the rapidity and transverse momentum range of |y| <0.5 and 0.35< pt <1.00 GeV/c . For both protons and antiprotons, transverse mass distributions become more convex from peripheral to central collisions demonstrating characteristics of collective expansion. The measured rapidity distributions and the mean transverse momenta versus rapidity are flat within |y| <0.5 . Comparisons of our data with results from model calculations indicate that in order to obtain a consistent picture of the proton (antiproton) yields and transverse mass distributions the possibility of prehadronic collective expansion may have to be taken into account
Evidence from d+Au measurements for final-state suppression of high hadrons in Au+Au collisions at RHIC
We report measurements of single-particle inclusive spectra and two-particle
azimuthal distributions of charged hadrons at high transverse momentum (high
) in minimum bias and central d+Au collisions at =200 GeV.
The inclusive yield is enhanced in d+Au collisions relative to binary-scaled
p+p collisions, while the two-particle azimuthal distributions are very similar
to those observed in p+p collisions. These results demonstrate that the strong
suppression of the inclusive yield and back-to-back correlations at high
previously observed in central Au+Au collisions are due to final-state
interactions with the dense medium generated in such collisions.Comment: Final journal version. Data tables for figures may be downloaded from
the STAR home page: http://www.star.bnl.gov --> Publications --> Access to
STAR published dat
Transverse momentum and collision energy dependence of high hadron suppression in Au+Au collisions at ultrarelativistic energies
We report high statistics measurements of inclusive charged hadron production
in Au+Au and p+p collisions at \sqrtsNN=200 GeV. A large, approximately
constant hadron suppression is observed in central Au+Au collisions for
5\lt\pT\lt12 GeV/c. The collision energy dependence of the yields and the
centrality and \pT dependence of the suppression provide stringent constraints
on theoretical models of suppression. Models incorporating initial-state gluon
saturation or partonic energy loss in dense matter are largely consistent with
observations. We observe no evidence of \pT-dependent suppression, which may be
expected from models incorporating jet attentuation in cold nuclear matter or
scattering of fragmentation hadrons.Comment: Final journal version. Data tables for figures may be downloaded from
the STAR home page: http://www.star.bnl.gov --> Publications --> Access to
STAR published dat
Azimuthally sensitive Hanbury Brown-Twiss interferometry in Au+Au collisions at sqrt(s_{NN}) = 200 GeV
We present the results of a systematic study of the shape of the pion
distribution in coordinate space at freeze-out in Au+Au collisions at RHIC
using two-pion Hanbury Brown-Twiss (HBT) interferometry. Oscillations of the
extracted HBT radii vs. emission angle indicate sources elongated perpendicular
to the reaction plane. The results indicate that the pressure and expansion
time of the collision system are not sufficient to completely quench its
initial shape.Comment: 6 pages, 4 figures, published versio
Particle-type dependence of azimuthal anisotropy and nuclear modification of particle production in Au+Au collisions at s(NN)**(1/2) = 200-GeV
We present STAR measurements of the azimuthal anisotropy parameter and
the binary-collision scaled centrality ratio for kaons and lambdas
() at mid-rapidity in Au+Au collisions at
GeV. In combination, the and
particle-type dependencies contradict expectations from partonic energy loss
followed by standard fragmentation in vacuum. We establish
GeV/c as the value where the centrality dependent baryon enhancement ends. The
and values are consistent with
expectations of constituent-quark-number scaling from models of hadron
fromation by parton coalescence or recombination.Comment: 6 pages, 4 figures, 1 table. As published in PRL on Feb. 2, 2004;
Significant revisions have been made to the text and color has been added to
plot
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