Trajectories of Anxiety and Depression Symptoms over Five Years since Breast Cancer Diagnosis: Results of the NEON-BC Prospective Study

Anxiety and depression symptoms are frequent among patients with breast cancer (BCa) and may last after initial treatments. We aimed to identify five-year trajectories of anxiety and depression symptoms among women with BCa. Neuro-oncological complications of BCa (NEON-BC) cohort included 506 patients admitted at the Portuguese Institute of Oncology of Porto in 2012, who were evaluated with the Hospital Anxiety and Depression Scale before cancer treatment and after one, three, and five years (7.9% attrition rate). Mixed-effect models were used to model anxiety and depression scores over time and model-based clustering to identify the different trajectories. Three trajectories of anxiety symptoms were identified: (1) high scores at baseline and increasing over time (21.7%); (2) consistently low scores over time (63.6%); (3) mid-range scores at baseline, decreasing over time (14.6%). Three trajectories were identified for depression symptoms: (1) high scores at baseline and increasing over time (21.1%); (2) mid-range scores at baseline, which decreased afterward (58.7%); (3) consistently low levels over time (20.2%). Age, education, baseline, and one-year anxiety/depression status predicted the worst five-year trajectories. These results show that assessing anxiety and depression symptoms before treatment and after one year may contribute to identifying the patients who could benefit the most from psychological support. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.This research was funded by the European Regional Development Funds (POCI-01-0145-FEDER016867) and Fundação para a Ciência e a Tecnologia (FCT), under the project “A five-year prospective cohort study on the neurological complications of breast cancer: frequency and impact in patient-reported outcomes” (PTDC/DTP-EPI/7183/2014), and by FCT under EPIUnit-Instituto de Saúde Pública da Universidade do Porto (UIDB/04750/2020) and Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (LA/P/0064/2020). NA receives funding from FCT under the project NeurodegCov19-Neurological Complications after COVID-19 (PTDC/SAU-EPI/6275/2020) and C.L., from FCT under the project NEON-PC: neuro-oncological complications of prostate cancer-longitudinal study of cognitive decline (POCI-01-0145-FEDER-032358, Ref. PTDC/SAU-EPI/32358/2017). Data management activities up to the first year of follow-up were supported by the Chair on Pain Medicine of the Faculty of Medicine, University of Porto, and the Grünenthal Foundation—Portugal

Pet ownership during the first 5 years after breast cancer diagnosis in the NEON-BC cohort

Background Although human-animal interactions (HAI) have been associated with health benefits, they have not been extensively studied among cancer patients nor which factors may influence HAI during cancer survivorship. Therefore, this study aims to describe pet ownership in a breast cancer cohort within 5 years post-diagnosis and to identify associated factors. Methods Four hundred sixty-six patients from the NEON-BC cohort were evaluated. Four groups of pet ownership over the 5 years were defined: 'never had', 'stopped having', 'started having' and 'always had'. Multinomial logistic regression was used to quantify the association between the patient characteristics and the groups defined (reference: 'never had'). Results 51.7% of patients had pets at diagnosis, which increased to 58.4% at 5 years; dogs and cats were the most common. Women presenting depressive symptoms and poor quality of life were more likely to stop having pets. Older and unpartnered women were less likely to start having pets. Those retired, living outside Porto, having diabetes or having owned animals during adulthood were more likely to start having pets. Women with higher education and unpartnered were less likely to always have pets. Those living in larger households, with other adults or having animals throughout life, were more likely to always have pets. Obese women had lower odds of stopping having dogs/cats. Women submitted to neoadjuvant chemotherapy and longer chemotherapy treatments were more likely to stop having dogs/cats. Conclusions Pet ownership changed over the 5 years and is influenced by sociodemographic, clinical and treatment characteristics, patient-reported outcomes and past pet ownership, reflecting the importance of HAI during cancer survivorship.This work was funded by FEDER through the Operational Programme Competitiveness and Internationalization and national funding from the Foundation for Science and Technology-FCT (Portuguese Ministry of Science, Technology and Higher Education) under the project 'A five-year prospective cohort study on the neurological complications of breast cancer: frequency and impact in patient-reported outcomes' (POCI-01-0145-FEDER016867, Ref. PTDC/DTP-EPI/7183/2014), and national funding from FCT under the Unidade de Investigacao em Epidemiologia-Instituto de Saude Publica da Universidade do Porto (EPIUnit) (UIDB/04750/2020). Individual grants attributed to NA (SFRH/BD/119390/2016) and FF (SFRH/BD/92630/2013) were funded by FCT and the 'Programa Operacional Capital Humano' (POCH/FSE). Data management activities up to the first year of follow-up were supported by the Chair on Pain Medicine of the Faculty of Medicine, University of Porto and by the Grunenthal Foundation-Portugal

Maternal sensitivity and mother-infant attachment are associated with antibiotic uptake in infancy

Attachment security has been associated with health status and symptom reporting. In this longitudinal study, we investigated the association between antibiotics uptake by infants at 9-months and mother-infant attachment at 12-months. Logistic regression analyses indicated that lower maternal sensitivity was associated with increased odds of antibiotic uptake. Furthermore, 89.7% of insecure-ambivalent infants consumed antibiotics, which contrasted with 32.5% of avoidant infants and 21.5% of secure infants. This study suggests that maternal behavior and mother-infant attachment impact on antibiotic consumption, which is worrying because antibiotics may lead to several health problems later in life and antibiotic-resistance.info:eu-repo/semantics/publishedVersio

IMPLEMENTAÇÃO DO AUTOCUIDADO APOIADO PARA PACIENTES COM DIABETES MELLITUS TIPO 2 ACOMPANHADOS EM UMA UNIDADE BÁSICA DE SAÚDE DA FAMILIA DO MUNICÍPIO DE LUZIÂNIA-GO

O diabetes mellitos tipo 2 é uma doença crônica, com impacto mundial, que pode apresentar muitas complicações caso não seja adequadamente controlada. Na Atenção Básica, principal porta de entrada aos problemas crônicos de saúde, algumas metodologias apresentam resultados importantes na luta contra as complicações das doenças crônicas, com atuação importante do enfermeiro, como o apoio ao autocuidado. O Autocuidado Apoiado visa capacitar o indivíduo para se tornar agente ativo no processo de controle da condição crônica, por meio da adesão as mudanças necessárias no seu estilo de vida, favorecida por essa ferramenta, com o auxílio e acompanhamento do enfermeiro

LATTES: a novel detector concept for a gamma-ray experiment in the Southern hemisphere

The Large Array Telescope for Tracking Energetic Sources (LATTES), is a novel concept for an array of hybrid EAS array detectors, composed of a Resistive Plate Counter array coupled to a Water Cherenkov Detector, planned to cover gamma rays from less than 100 GeV up to 100 TeVs. This experiment, to be installed at high altitude in South America, could cover the existing gap in sensitivity between satellite and ground arrays. The low energy threshold, large duty cycle and wide field of view of LATTES makes it a powerful tool to detect transient phenomena and perform long term observations of variable sources. Moreover, given its characteristics, it would be fully complementary to the planned Cherenkov Telescope Array (CTA) as it would be able to issue alerts. In this talk, a description of its main features and capabilities, as well as results on its expected performance, and sensitivity, will be presented.Comment: Proceedings of the 35th International Cosmic Ray Conference (ICRC2017), Busan, South Korea. Presented by R. Concei\c{c}\~{a}o. 8 pages; v2: correct affiliation + journal referenc

Avaliação da temperatura superficial de telhas por termografia.

Projeto: 11.11.11.111

Quality of life trajectories in breast cancer patients: an updated analysis 5 years after diagnosis

Letter to the editorThis work was funded by FEDER through the Operational Programme Competitiveness and Internationalization and national funding from the Foundation for Science and Technology—FCT (Portuguese Ministry of Science, Technology and Higher Education) under the project ‘A five-year prospective cohort study on the neurological complications of breast cancer: frequency and impact in patient-reported outcomes’ (POCI-01-0145-FEDER-016867, Ref. PTDC/DTP-EPI/7183/2014), and national funding from FCT under the Unidade de Investigação em Epidemiologia—Instituto de Saúde Pública da Universidade do Porto (EPIUnit) (POCI-01-0145-FEDER-016867, Ref. PTDC/DTP-EPI/7183/2014), and national funding from FCT under the Unidade de Investigação em Epidemiologia - Instituto de Saúde Pública da Universidade do Porto (EPIUnit) (info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/04750/2020/PT). LLC was funded under the scope of the project ‘NEON-PC—Neuro-oncological complications of prostate cancer: longitudinal study of cognitive decline’ (POCI01–0145-FEDER-032358; ref. PTDC/SAU-EPI/32358/2017). Individual grants attributed to NA (SFRH/BD/119390/2016) and FF (SFRH/BD/92630/2013) were funded by FCT and the ‘Programa Operacional Capital Humano’ (POCH/FSE). Data management activities up to the first year of follow-up were supported by the Chair on Pain Medicine of the Faculty of Medicine, University of Porto, and by the Grünenthal Foundation—Portugal

Avaliação multi-modal e problemas diagnósticos da trombose venosa cerebral

Comunicação apresentada no Congresso da Sociedade Portuguesa de Neuroradiologia, 5, Figueira da Foz, 29 e 30 de Maio de 200

Alterações do desenvolvimento do manto cortical e calcificações em ressonância magnética fetal

Poster apresentado no Congresso da Sociedade Portuguesa de Neuroradiologia, 5, Figueira da Foz, 29 e 30 de Maio de 200

Cancer-Related Neuropathic Pain, Chemotherapy-Induced Peripheral Neuropathy and Cognitive Decline in a 5-Year Prospective Study of Patients with Breast Cancer—NEON-BC

This study aims to estimate the prevalence and to identify the determinants of cancer-related neuropathic pain (CRNP), chemotherapy-induced peripheral neuropathy (CIPN) and cognitive decline among patients with breast cancer over five years after diagnosis. Women with an incident breast cancer (n = 462) and proposed for surgery were recruited at the Portuguese Institute of Oncology-Porto in 2012 and underwent systematic neurological examinations and evaluations with the Montreal Cognitive Assessment (MoCA) before treatment and after one, three, and five years. Multivariate logistic regression was used to assess the determinants of CRNP and CIPN, and multivariate linear regression for the variation in MoCA scores. Prevalence of CRNP and CIPN decreased from the first to the fifth year after diagnosis (CRNP: from 21.1% to 16.2%, p = 0.018; CIPN: from 22.0% to 16.0% among those undergoing chemotherapy, p = 0.007). Cognitive impairment was observed in at least one assessment in 17.7% of the women. Statistically significant associations were observed between: cancer stage III and both CRNP and CIPN; triple negative breast cancer, chemotherapy, axillary node dissection, older age, higher education, and being single and CRNP; taxanes and fruit and vegetable consumption and CIPN. Anxiety, depression and poor sleep quality at baseline were associated with decreases in MoCA values from pre- to post-treatment and with CRNP. Follow-up protocols should consider the persistence of CRNP, CIPN, and cognitive impairment for several years following diagnosis. © 2023 by the authors.Funding: Data management activities at baseline and one-year follow-up were supported by the Chair on Pain Medicine of the Faculty of Medicine, University of Porto and by the Grünenthal Foundation-Portugal. Three-and five-year evaluations were conducted within the research activities of the Unidade de Investigação em Epidemiologia—Instituto de Saúde Pública da Universidade do Porto (EPIUnit, UIDB/04750/2020) and Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR, LA/P/0064/2020) funded by national funding from the Foundation for Science and Technology—FCT (Portuguese Ministry of Science, Technology and Higher Education), and of the project ‘A five-year prospective cohort study on the neurological complications of breast cancer: frequency and impact in patient-reported outcomes’ (POCI-01-0145-FEDER-016867, Ref. PTDC/DTP-EPI/7183/2014) funded by ERDF through the Operational Programme Competitiveness and Internationalization and by FCT. L.L-C. and S.M. were also funded under the scope of the project “NEON-PC—Neuro-oncological complications of prostate cancer: longitudinal study of cognitive decline” (POCI-01-0145-FEDER-032358; ref. PTDC/SAU-EPI/32358/2017). Individual grants attributed to N.A. (SFRH/BD/119390/2016) and F.F. (SFRH/BD/92630/2013) were funded by FCT and the ‘Programa Operacional Capital Humano’ (POCH/FSE)