1,047 research outputs found
Null Deformed Domain Wall
We study null 1/4 BPS deformations of flat domain wall solutions (NDDW) in
N=2, d=5 gauged supergravity with hypermultiplets and vector multiplets
coupled. These are uncharged time-dependent configurations and contain as
special case, 1/2 supersymmetric flat domain walls (DW), as well as 1/2 BPS
null solutions of the ungauged supergravity. Combining our analysis with the
classification method initiated by Gauntlett et al., we prove that all the
possible deformations of the DW have origin in the hypermultiplet sector or/and
are null. Here, we classify all the null deformations: we show that they
naturally organize themselves into "gauging" (v-deformation) and "non gauging"
(u-deformation). They have different properties: only in presence of
v-deformation is the solution supported by a time-dependent scalar potential.
Furthermore we show that the number of possible deformations equals the number
of matter multiplets coupled. We discuss the general procedure for constructing
explicit solutions, stressing the crucial role taken by the integrability
conditions of the scalars as spacetime functions. Two analytical solutions are
presented. Finally, we comment on the holographic applications of the NDDW, in
relation to the recently proposed time-dependent AdS/CFT.Comment: 38 pages; minor changes, references added; text revised, minor
changes, final version published in JHE
5D Attractors with Higher Derivatives
We analyze higher derivative corrections to attractor geometries in five
dimensions. We find corrected AdS_3xS^2 geometries by solving the equations of
motion coming from a recently constructed four-derivative supergravity action
in five dimensions. The result allows us to explicitly verify a previous
anomaly based derivation of the AdS_3 central charges of this theory. Also, by
dimensional reduction we compare our results with those of the 4D higher
derivative attractor, and find complete agreement.Comment: 18 pages, harvma
Cosmological solutions from fake N=2 EYM supergravity
We characterise the (fake) supersymmetric solutions of Wick-rotated N=2 d=4
gauged supergravity coupled to non-Abelian vector multiplets. In the time-like
case we obtain generalisations of Kastor & Traschen's cosmological black holes:
they have a specific time-dependence and the base-space must be 3-dimensional
hyperCR/Gauduchon-Tod space. In the null-case, we find that the metric has a
holonomy contained in Sim(2), give a general characterisation of the solutions,
and give some examples. Finally, we point out that in some cases the solutions
we found are non-BPS solutions to N=2 d=4 supergravity coupled to vector
multiplets.Comment: 30 pages. Comments and references added, typos correcte
HOPX functions as a tumour suppressor in head and neck cancer.
Head and neck squamous cell carcinoma (HNSCC) is generalized term that encompasses a diverse group of cancers that includes tumours of the oral cavity (OSCC), oropharynx (OPSCC) and nasopharynx (NPC). Genetic alterations that are common to all HNSCC types are likely to be important for squamous carcinogenesis. In this study, we have investigated the role of the homeodomain-only homeobox gene, HOPX, in the pathogenesis of HNSCC. We show that HOPX mRNA levels are reduced in OSCC and NPC cell lines and tissues and there is a general reduction of HOPX protein expression in these tumours and OPSCCs. HOPX promoter methylation was observed in a subset of HNSCCs and was associated with a worse overall survival in HPV negative tumours. RNAseq analysis of OSCC cells transfected with HOPX revealed a widespread deregulation of the transcription of genes related to epithelial homeostasis and ectopic over-expression of HOPX in OSCC and NPC cells inhibited cell proliferation, plating efficiency and migration, and enhanced sensitivity to UVA-induced apoptosis. Our results demonstrate that HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis
LocalEnergy: Local Resources for Multifunctional Tetrahedrite-based Energy: Harvesting Applications
info:eu-repo/semantics/publishedVersio
Histological and ultrastructural feature and nitrite production of caprine preantral follicles in vitro cultured in the presence or absence of serum
Avaliou-se o efeito da adição de diferentes tipos e concentrações de soro sobre o desenvolvimento e a sobrevivência de folículos ovarianos pré-antrais (FOPA) caprinos in vitro. Além disso, verificou-se a relação entre as concentrações de nitrito presentes no meio de cultivo e a viabilidade folicular. Cada par ovariano foi dividido em 29 fragmentos, sendo um destinado ao controle. Os fragmentos foram cultivados por um ou sete dias em meio essencial mínimo suplementado (MEM+) ou MEM+ com diferentes concentrações (10 ou 20%) de soro fetal bovino (SFB), soro de cabra em estro (SCE) ou soro de cabra em diestro (SCD). Na análise morfológica após sete dias, apenas o tratamento com 10% de SFB apresentou percentual de FOPA normais similar ao MEM+ (P>0,05). A análise ultra-estrutural dos folículos cultivados por sete dias com MEM+ ou MEM+ com 10% de SFB mostrou danos oocitários, porém células da granulosa normais. A análise do meio de cultivo revelou correlação positiva entre a viabilidade folicular e a produção de nitrito. A suplementação com soro não melhorou a viabilidade de FOPA e a concentração de nitrito no meio de cultivo funcionou como um indicador da viabilidade das células da granulosa de FOPA caprinos cultivados in vitro. ______________________________________________________________________________________________________________ ABSTRACTThe effect of the addition of different types and concentrations of sera on the viability and development of caprine preantal follicles (PAF) in vitro cultured was analyzed. In addition, it was evaluated the correlation between nitrite concentrations in culture medium and folicular viability. Each ovarian pair was divided in 29 fragments and one was used as control. The fragments were cultured for one or seven days in minimal essential medium (MEM+) or MEM+ with different concentrations of (10 or 20%) bovine fetal serum (BFS), estrous goat serum (EGS), or diestrous goat serum (DGS). After seven days, the morphological analysis showed that only the treatment with 10% BFS maintained the percentage of normal PAF similar to MEM+ (P>0.05). The ultrastructural analysis of follicles cultured for seven days in MEM+ or MEM+ with 10% BFS showed some oocyte damage, although the granulosa cells were normal. Analysis of culture medium revealed a positive correlation between follicular viability and nitrite production. Supplementation with serum did not improve the viability of PAF and nitrite levels in culture medium served as an indicator of viability of granulose cells from caprine PAF in vitro cultured
Dipolar interactions and anisotropic magnetoresistance in metallic granular systems
We revisit the theory of magnetoresistance for a system of nanoscopic
magnetic granules in metallic matrix. Using a simple model for the spin
dependent perturbation potential of the granules, we solve Boltzmann equation
for the spin dependent components of the non equilibrium electronic
distribution function. For typical values of the geometric parameters in
granular systems, we find a peculiar structure of the distribution function of
conduction electrons, which is at variance with the two-current model of
conduction in inhomogeneous systems. Our treatment explicitly includes the
effects of dipolar correlations yielding a magnetoresistance ratio which
contains, in addition to the term proportional to the square of uniform
magnetization (), a weak anisotropic contribution
depending on the angle between electric and magnetic fields, and arising from
the anisotropic character of dipolar interactions.Comment: 9 pages, 2 figures, accepted in PR
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