Atopic Dermatitis Host and Environment Model: Revisiting Therapeutic Options

Atopic Dermatitis affects both children and adults and is a serious health concern in many countries. AD is a complex disease with host and environmental factors underlying its pathology. Its treatment is multidimensional reflecting the diverse nature of its triggers and includes emollients, topical steroids and calcineurin inhibitors among others. Immunological dysfunction can be addressed broadly with systemic immunosupressors and specifically with monoclonal antibodies. Dupilumab, which targets IL-4 and IL-13 was granted approval for treatment of moderate-to-severe AD. Biologics targeting IgE/Th2 pathways may have its role in patients with overlapping AD and asthma. Psychological distress can exacerbate symptoms and is associated with increased severity of AD. Environmental triggers, such as, allergens can be addressed in selected cases with allergic immunotherapy. In this paper, we discuss AD treatment and propose a new step-by-step approach aiming at maintaining disease control and improving quality of life.info:eu-repo/semantics/publishedVersio

Large time behavior for vortex evolution in the half-plane

In this article we study the long-time behavior of incompressible ideal flow in a half plane from the point of view of vortex scattering. Our main result is that certain asymptotic states for half-plane vortex dynamics decompose naturally into a nonlinear superposition of soliton-like states. Our approach is to combine techniques developed in the study of vortex confinement with weak convergence tools in order to study the asymptotic behavior of a self-similar rescaling of a solution of the incompressible 2D Euler equations on a half plane with compactly supported, nonnegative initial vorticity.Comment: 30 pages, no figure