134 research outputs found
Crestwood Lumber Company v. Citizens Savings & Loan Association: The Ursury Law and Liquidated Damages in the Sale of Goods Transactions
Crestwood Lumber Company v. Citizens Savings & Loan Association: The Ursury Law and Liquidated Damages in the Sale of Goods Transactions
There Is Something in the Air: The Legal Implications of Podcasting and User Generated Context
Recommended from our members
Fall 1967
Massachusetts Turf and Lawn Grass CouncilBetter Turf Through Research and Educatio
Reliability Of Benefit Value Transfers From Contingent Valuation Data With Forest-Specific Attributes
Prime Focus Spectrograph (PFS) for the Subaru Telescope: Overview, recent progress, and future perspectives
PFS (Prime Focus Spectrograph), a next generation facility instrument on the
8.2-meter Subaru Telescope, is a very wide-field, massively multiplexed,
optical and near-infrared spectrograph. Exploiting the Subaru prime focus, 2394
reconfigurable fibers will be distributed over the 1.3 deg field of view. The
spectrograph has been designed with 3 arms of blue, red, and near-infrared
cameras to simultaneously observe spectra from 380nm to 1260nm in one exposure
at a resolution of ~1.6-2.7A. An international collaboration is developing this
instrument under the initiative of Kavli IPMU. The project is now going into
the construction phase aiming at undertaking system integration in 2017-2018
and subsequently carrying out engineering operations in 2018-2019. This article
gives an overview of the instrument, current project status and future paths
forward.Comment: 17 pages, 10 figures. Proceeding of SPIE Astronomical Telescopes and
Instrumentation 201
Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes
PURPOSE: Invasive mucinous adenocarcinoma (IMA) is a unique subtype of lung adenocarcinoma, characterized genomically by frequent KRAS mutations or specific gene fusions, most commonly involving NRG1. Comprehensive analysis of a large series of IMAs using broad DNA- and RNA-sequencing methods is still lacking, and it remains unclear whether molecular subtypes of IMA differ clinicopathologically.
EXPERIMENTAL DESIGN: A total of 200 IMAs were analyzed by 410-gene DNA next-generation sequencing (MSK-IMPACT; n = 136) or hotspot 8-oncogene genotyping (n = 64). Driver-negative cases were further analyzed by 62-gene RNA sequencing (MSK-Fusion) and those lacking fusions were further tested by whole-exome sequencing and whole-transcriptome sequencing (WTS).
RESULTS: Combined MSK-IMPACT and MSK-Fusion testing identified mutually exclusive driver alterations in 96% of IMAs, including KRAS mutations (76%), NRG1 fusions (7%), ERBB2 alterations (6%), and other less common events. In addition, WTS identified a novel NRG2 fusion (F11R-NRG2). Overall, targetable gene fusions were identified in 51% of KRAS wild-type IMAs, leading to durable responses to targeted therapy in some patients. Compared with KRAS-mutant IMAs, NRG1-rearranged tumors exhibited several more aggressive characteristics, including worse recurrence-free survival (P \u3c 0.0001).
CONCLUSIONS: This is the largest molecular study of IMAs to date, where we demonstrate the presence of a major oncogenic driver in nearly all cases. This study is the first to document more aggressive characteristics of NRG1-rearranged IMAs, ERBB2 as the third most common alteration, and a novel NRG2 fusion in these tumors. Comprehensive molecular testing of KRAS wild-type IMAs that includes fusion testing is essential, given the high prevalence of alterations with established and investigational targeted therapies in this subset
The ALMA Interferometric Pipeline Heuristics
We describe the calibration and imaging heuristics developed and deployed in
the ALMA interferometric data processing pipeline, as of ALMA Cycle 9. The
pipeline software framework is written in Python, with each data reduction
stage layered on top of tasks and toolkit functions provided by the Common
Astronomy Software Applications package. This framework supports a variety of
tasks for observatory operations, including science data quality assurance,
observing mode commissioning, and user reprocessing. It supports ALMA and VLA
interferometric data along with ALMA and NRO45m single dish data, via different
stages and heuristics. In addition to producing calibration tables, calibrated
measurement sets, and cleaned images, the pipeline creates a WebLog which
serves as the primary interface for verifying the data quality assurance by the
observatory and for examining the contents of the data by the user. Following
the adoption of the pipeline by ALMA Operations in 2014, the heuristics have
been refined through annual development cycles, culminating in a new pipeline
release aligned with the start of each ALMA Cycle of observations. Initial
development focused on basic calibration and flagging heuristics (Cycles 2-3),
followed by imaging heuristics (Cycles 4-5), refinement of the flagging and
imaging heuristics with parallel processing (Cycles 6-7), addition of the
moment difference analysis to improve continuum channel identification (2020
release), addition of a spectral renormalization stage (Cycle 8), and
improvement in low SNR calibration heuristics (Cycle 9). In the two most recent
Cycles, 97% of ALMA datasets were calibrated and imaged with the pipeline,
ensuring long-term automated reproducibility. We conclude with a brief
description of plans for future additions, including self-calibration,
multi-configuration imaging, and calibration and imaging of full polarization
data.Comment: accepted for publication by Publications of the Astronomical Society
of the Pacific, 65 pages, 20 figures, 10 tables, 2 appendice
- …