63 research outputs found
A reference relative time-scale as an alternative to chronological age for cohorts with long follow-up
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Background: Epidemiologists have debated the appropriate time-scale for cohort survival studies; chronological age or time-on-study being two such time-scales. Importantly, assessment of risk factors may depend on the choice of time-scale. Recently, chronological or attained age has gained support but a case can be made for a ‘reference relative time-scale’ as an alternative which circumvents difficulties that arise with this and other scales. The reference relative time of an individual participant is the integral of a reference population hazard function between time of entry and time of exit of the individual. The objective here is to describe the reference relative time-scale, illustrate its use, make comparison with attained age by simulation and explain its relationship to modern and traditional epidemiologic methods.
Results: A comparison was made between two models; a stratified Cox model with age as the time-scale versus an un-stratified Cox model using the reference relative time-scale. The illustrative comparison used a UK cohort of cotton workers, with differing ages at entry to the study, with accrual over a time period and with long follow-up. Additionally, exponential and Weibull models were fitted since the reference relative time-scale analysis need not be restricted to the Cox model. A simulation study showed that analysis using the reference relative time-scale and analysis using chronological age had very similar power to detect a significant risk factor and both were equally unbiased. Further, the analysis using the reference relative time-scale supported fully-parametric survival modelling and allowed percentile predictions and mortality curves to be constructed.
Conclusions: The reference relative time-scale was a viable alternative to chronological age, led to simplification of the modelling process and possessed the defined features of a good time-scale as defined in reliability theory. The reference relative time-scale has several interpretations and provides a unifying concept that links contemporary approaches in survival and reliability analysis to the traditional epidemiologic methods of Poisson regression and standardised mortality ratios. The community of practitioners has not previously made this connection
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- Author
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- Abdallah J
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- Trochimczuk M
- Trocme B
- Trocsanyi Z
- Troncon C
- Tsur E
- Tuchming B
- Tully C
- Tung KL
- Turluer ML
- Turner-Watson MF
- Tyapkin IA
- Tyapkin P
- Tzamarias S
- Uchida Y
- Ueda I
- Ujvari B
- Ulbricht J
- Uvarov V
- Vachon B
- Valassi A
- Valente E
- Valenti G
- Vallage B
- van Dalen JA
- Van Dam P
- van de Walle RT
- van Dierendonck D
- Van Eldik J
- van Gulik R
- Van Lysebetten A
- van Remortel N
- Van Vulpen I
- Vannerem P
- Vayaki A
- Vegni G
- Veillet JJ
- Veloso F
- Venturi A
- Venus W
- Verbeure F
- Verdier P
- Verdini PG
- Verzi V
- Verzocchi M
- Veszpremi V
- Vesztergombi G
- Vetlitsky I
- Vicinanza D
- Videau H
- Videau I
- Viertel G
- Vilanova D
- Villa S
- Vitale L
- Vivargent M
- Vlachos S
- Vodopianov I
- Vogel H
- Vogt H
- Vollmer CF
- von Krogh J
- von Wimmersperg-Toeller JH
- Vorobiev I
- Vorobyov AA
- Voss H
- Vossebeld J
- Vrba V
- Waananen A
- Wachsmuth H
- Wadhwa M
- Wahlen H
- Waller D
- Wallraff W
- Wang M
- Wang T
- Wang XL
- Wang ZM
- Ward CP
- Ward DR
- Ward JJ
- Washbrook AJ
- Wasserbacch S
- Watkins PM
- Watson AT
- Watson NK
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- Weiser C
- Well PS
- Wengler T
- Wermes N
- Werner S
- Wetterling D
- White R
- Wicke D
- Wickens J
- Wiedenmann W
- Wienemann P
- Wilkens H
- Wilkinson G
- Wilson GW
- Wilson JA
- Winter M
- Witek M
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- Wolf G
- Wu J
- Wu SL
- Wu SX
- Wu X
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- Wyatt TR
- Wynhoff S
- Xia L
- Xie Y
- Xu R
- Xu ZZ
- Xue S
- Yamamoto J
- Yamashita S
- Yang BZ
- Yang CG
- Yang HJ
- Yang M
- Yeh SC
- Yuan C
- Yushchenko O
- Zachariadou K
- Zalewska A
- Zalewski P
- Zalite A
- Zalite Y
- Zavrtanik D
- Zeitnitz C
- Zer-Zion D
- Zhang J
- Zhang L
- Zhang ZP
- Zhao J
- Zhao W
- Zhu GY
- Zhu RY
- Zhuang HL
- Zhuravlov V
- Zichichi A
- Ziegler T
- Zilizi G
- Zimin NI
- Zimmermann B
- Zintchenko A
- Zito G
- Zivkovic L
- Zobernig G
- Zoller M
- Zupan M
- Publication venue
- ELSEVIER SCIENCE BV
- Publication date
- 17/07/2003
- Field of study
Tactual perception: a review of experimental variables and procedures
- Author
- A Abramowicz
- A Bigelow
- A Cruz
- A Gallace
- A Gallace
- A Gallace
- A Kaas
- A Kilgour
- A Postma
- A Streri
- AFJ Sanders
- Alexandra M. Fernandes
- AML Kappers
- AT Woods
- AT Woods
- B Guclu
- B Röder
- BJ Horst van der
- BL Richardson
- C Cinel
- C Cornoldi
- C Ho
- C Simões-Franklin
- C Spence
- CE Sherrick
- CP Garbin
- D Catherwood
- D Corbetta
- D Freides
- D Homa
- D Picard
- D Picard
- D Sanabria
- D Sanabria
- EW Bushnell
- F Alary
- F Alary
- F Willis
- FN Newell
- G Geffen
- G Geffen
- GH Doorn Van
- H Cohen
- H Gillmeister
- I Bülthoff
- J Bardwick
- J Bliss
- J Bresciani
- J Craig
- J Delwiche
- J Gibson
- J Stevens
- J Trojan
- J Zimler
- J-P Bresciani
- JF Norman
- JHF Bult
- JJ Goodnow
- JM Loomis
- K Hötting
- K Sathian
- L Hagander
- LM Stadtlander
- M Auvray
- M Auvray
- M Auvray
- M Craddock
- M Craddock
- M Heller
- M Heller
- M Lhote
- M Turvey
- M Zampini
- MA Heller
- MA Plaisier
- MJ Kiphart
- MJ Kiphart
- ML Demattè
- MO Ernst
- N Kanwisher
- N Sadato
- NA Giudice
- P Bach-y-Rita
- P Bruns
- Pedro B. Albuquerque
- R Easton
- R Easton
- R Lawson
- R Lawson
- RL Klatzky
- RL Klatzky
- RL Klatzky
- RL Klatzky
- RL Klatzky
- RL Klatzky
- RT Verrillo
- RT Verrillo
- S Ballesteros
- S Lacey
- S Lacey
- S Lacey
- S Louw
- S Zuidhoek
- SJ Casey
- SJ Casey
- SJ Lederman
- SJ Lederman
- SJ Lederman
- SJ Lederman
- SJ Lederman
- SJ Lederman
- T Bancroft
- TA Whitaker
- TW James
- V Bruce
- V Cronin
- V Occelli
- WMB Bergmann-Tiest
- Y Hatwell
- Z Cattaneo
- Z Cattaneo
- Z Cattaneo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
This paper reviews literature on tactual perception. Throughout this review we will highlight some of the most relevant variables in touch literature: interaction between touch and other senses; type of stimuli, from abstract stimuli such as vibrations, to two- and three-dimensional stimuli, also considering concrete stimuli such as the relation between familiar and unfamiliar stimuli or the haptic perception of faces; type of participants, separating studies with blind participants, studies with children and adults, and an analysis of sex differences in performance; and finally, type of tactile exploration, considering conditions of active and passive touch, the relevance of movement in touch and the relation between exploration and time. This review intends to present an organised overview of the main variables in touch experiments, attending to the main findings described in literature, to guide the design of future works on tactual perception and memory.This work was funded by the Portuguese “Foundation for Science and Technology” through PhD scholarship SFRH/BD/35918/2007
Purinergic signalling and immune cells
- Author
- A Ben Addi
- A Ben Addi
- A Buenestado
- A Cuschieri
- A Filippini
- A Fortin
- A Grenz
- A Harish
- A Kaufmann
- A Kawano
- A Kawano
- A Leoutsakos
- A McRae
- A McRae
- A Ohta
- A Piccini
- A Rey del
- A Sala la
- A Sala la
- A Schmidt
- A Serafeim
- A Shin
- A Tokunaga
- A Vergani
- A Vergani
- A Yang
- AA Chimote
- AA Link
- AA Santos Jr
- AC Newby
- AG Orr
- AJ Sharp
- AL Horenstein
- AL Schwartz
- AM Forsyth
- AN Shemon
- AW Ford-Hutchinson
- AY Warren
- B Brône
- B Csóka
- B Csóka
- B Csóka
- B Diamant
- B Gu
- B Newson
- B Sperlágh
- BA Walker
- BA Walker
- BB Fredholm
- BB Fredholm
- BC Chen
- BC Chen
- BC Suh
- BD Freedman
- BD Humphreys
- BD Humphreys
- BG Campos
- BH Lee
- BJ Gu
- BJ Gu
- BJ Gu
- BM Saunders
- BN Cronstein
- BN Cronstein
- BN Cronstein
- BN Cronstein
- BP Ramakers
- BP Ramakers
- C Cappelli
- C Cekic
- C el-Moatassim
- C el-Moatassim
- C Feng
- C Furlan-Freguia
- C Lecut
- C Lecut
- C Mutini
- C Pizzirani
- C Ponti De
- C Seror
- CB Grahames
- CD McWhinney
- CE Gargett
- CI Ezeamuzie
- CI Ezeamuzie
- CK Ayata
- CM Cruz
- CM Lappas
- CM Lappas
- CM Wang
- CP Nielson
- CP Sevigny
- CS Soledade
- D Bald
- D Barbieri
- D Biswas
- D Brough
- D Brough
- D Eschke
- D Ferrari
- D Ferrari
- D Ferrari
- D Ferrari
- D Ferrari
- D Ferrari
- D Ferrari
- D Ferrari
- D Hoeven van der
- D Hoeven van der
- D Knight
- D Lappin
- D Lappin
- D Myrtek
- D Myrtek
- D Perregaux
- DA Lammas
- DB Kuhns
- DC Altieri
- DJ Kusner
- DJ Kusner
- DJ Schrier
- DK Blanchard
- DL Marquardt
- DL Marquardt
- DL Marquardt
- DS Burt
- DW Riches
- E Adinolfi
- E Asgari
- E Bulanova
- E Bulanova
- E Bulanova
- E Chelmicka-Schorr
- E Crivellato
- E Krump
- E Panther
- E Panther
- E Panther
- E Velot
- ER Lazarowski
- F Aeffner
- F Alkayed
- F Anselmi
- F Aswad
- F Aswad
- F Ben Yebdri
- F Bretschneider
- F Ghaemi Oskouie
- F Grassi
- F Haag
- F Jacob
- F Jeffe
- F Laghi Pasini
- F Laghi Pasini
- F Markwardt
- F Marteau
- F Marteau
- F Rassendren
- F Scheuplein
- F Tuluc
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Virgilio Di
- F Wilkin
- F Wilkin
- FB Chekeni
- FC Weber
- FE Parkinson
- FM Konrad
- FR Rose
- G Beldi
- G Borsellino
- G Burnstock
- G Burnstock
- G Burnstock
- G Burnstock
- G Burnstock
- G Burnstock
- G Corrêa
- G Elson
- G Giannattasio
- G Gomez
- G Haskó
- G Haskó
- G Haskó
- G Haskó
- G Krüger
- G Lin
- G Marone
- G Marone
- G Marone
- G Marone
- G Marone
- G Martel-Gallegos
- G Petrovski
- G Vanderstocken
- G Vanderstocken
- G Wolberg
- G Wolberg
- GA Weisman
- GE Hardart
- Geoffrey Burnstock
- GJ Hallak
- GK Akbar
- GL Silva da
- GP Jamieson
- GP Smith
- GP Smith
- GR Dubyak
- GR Somers
- GW Sullivan
- H Asako
- H Bessler
- H Chen
- H Kawamura
- H Kawamura
- H Kettenmann
- H Moon
- H Saito
- H Sakaki
- H Zhong
- HK Eltzschig
- HK Eltzschig
- HK Eltzschig
- HK Takahashi
- HK Takahashi
- HM Costa-Junior
- HM Costa-Junior
- HP Buisman
- HP Langston
- HW Young
- I Bar
- I Drygiannakis
- I Ernens
- I Feoktistov
- I Garcia-Castro
- I Jalilian
- I Kaufmann
- I Lemaire
- I Lemaire
- I Marriott
- I Nagaoka
- I Pechán
- ID Mascanfroni
- IJ Elenkov
- IP Fairbairn
- J Barankiewicz
- J Barankiewicz
- J Bienenstock
- J Bienenstock
- J Challier
- J Dornand
- J Lin
- J Linden
- J Pfeilschifter
- J Reutershan
- J Xaus
- JA Auchampach
- JA Burgers
- JA Kiernan
- JA Kiernan
- JA Sommer
- JD Levine
- JE Hazleton
- JE Kim
- JE Salmon
- JE Salmon
- Jean-Marie Boeynaems
- JG Foster
- JG Kilian
- JG Mohanty
- JG Zhang
- JH Wilkinson
- JI Elliott
- JI Sesma
- JJ Field
- JJ Kobie
- JK Murphy
- JM Armstrong
- JM Langosch
- JM Sanz
- JM Wilson
- JM Wilson
- JR Fozard
- JS Cadieux
- JS Wiley
- JS Wiley
- JS Wiley
- JT Keller
- JT Merrill
- JW DePierre
- JW Goding
- K Atarashi
- K Barczyk
- K Christenson
- K Delmich
- K Färber
- K Heiss
- K Inoue
- K Inoue
- K McCallion
- K Niemi
- K Ohsawa
- K Ohsawa
- K Sugiyama
- K Varani
- K Varani
- K Varani
- K Varani
- K Wareham
- K Wilhelm
- K Yasui
- KE Barletta
- KL Han
- KL Wallace
- KM Dwyer
- KM Dwyer
- KR Vaughan
- KS Madden
- L Antonioli
- L Antonioli
- L Antonioli
- L Bazzichi
- L Chen
- L Genton
- L Himer
- L Homolya
- L Mircevová
- L Skelton
- L Stokes
- L Vitiello
- L Wang
- L Yip
- LA Schultz
- LC Denlinger
- LJ Murphree
- LM Hill
- LM Kreckler
- LM Zheng
- LY Lenertz
- M Aga
- M Baroni
- M Butler
- M Frascoli
- M Horckmans
- M Idzko
- M Idzko
- M Idzko
- M Idzko
- M Idzko
- M Idzko
- M Idzko
- M Idzko
- M Koshiba
- M Koshiba
- M Koshiba
- M Kronlage
- M Kuroki
- M Lucattelli
- M Mandapathil
- M Manohar
- M Mirabet
- M Murgia
- M Murgia
- M Nakanishi
- M Nakanishi
- M Nakano
- M Nikolova
- M Nikolova
- M Nowak
- M Nowak-Machen
- M Perez-Aso
- M Pospísil
- M Sakowicz-Burkiewicz
- M Salmi
- M Schnurr
- M Schnurr
- M Schnurr
- M Scrivens
- M Scrivens
- M Seman
- M Sitkovsky
- M Subramanian
- M Takedachi
- M Thiel
- M Tonetti
- M Tonetti
- M Tsuda
- M Tsukimoto
- M Tsukimoto
- M Warny
- MA Ventura
- MD Desrosiers
- MD Wewers
- MG Bouma
- MJ Lohse
- MK Church
- MK Church
- MK Church
- MM Chaves
- MO Barrett
- MP Lees
- MR Elliott
- MS Alam
- MV Sitkovsky
- MV Sitkovsky
- N Arizono
- N Bles
- N Bles
- N Grosman
- N Li
- N McNamara
- N Mizumoto
- N Thibault
- O Leavy
- OK Nihei
- OR Baricordi
- OR Baricordi
- P Chiozzi
- P Pelegrin
- P Schubert
- P Schubert
- PA Beavis
- PA Beavis
- PA Lang
- PA Ward
- PA Ward
- PB Ernst
- PE Ross
- PE Tatham
- PE Zarek
- PJ Hanley
- PJ Hughes
- PJ Hughes
- PT Peachell
- PT Smith
- PV Nagy
- QH Liu
- R Corriden
- R Corriden
- R Coutinho-Silva
- R Coutinho-Silva
- R Coutinho-Silva
- R Coutinho-Silva
- R Coutinho-Silva
- R Dahlquist
- R Hamano
- R Keller
- R Krishnaraj
- R Krishnaraj
- R Mandler
- R Placido
- R Rizzo
- R Seifert
- R Sluyter
- R Sluyter
- R Suzuki
- R Zeiser
- RA Axtell
- RB Banati
- RD Salter
- RF Fishman
- RF Kefford
- RF Zanin
- RH Straub
- RI Ludowyke
- RJ Griffiths
- RM Williams
- RR Aksamit
- S Adriouch
- S Arandjelovic
- S Armstrong
- S Berchtold
- S Cicko
- S Cockcroft
- S Cockcroft
- S Cockcroft
- S Colli
- S Deaglio
- S Deaglio
- S Dichmann
- S Falzoni
- S Franco-Martínez
- S Gardella
- S Gessi
- S Gessi
- S Gessi
- S Gorini
- S Greenberg
- S Huang
- S Hubert
- S Ikehara
- S Koizumi
- S Koizumi
- S Lépine
- S Padeh
- S Ring
- S Ryzhov
- S Sengstake
- S Trabanelli
- S Tsuruta
- S Tsutsui
- SD Skaper
- SD Skaper
- SE Haynes
- SE Hickman
- SF Häusler
- SF Moore
- SG Apasov
- SG Apasov
- SH Gregory
- SJ Leibovich
- SL Fernando
- SL Tilley
- SL Tilley
- SM O'Grady
- SP Chaves
- SQ Yao
- SR McColl
- SS Sung
- SV Novitskiy
- SY Eun
- T Henriksson
- T Johansen
- T Kobayashi
- T Kusu
- T Müller
- T Priebe
- T Raskovalova
- T Watanabe
- T Woehrle
- T Woehrle
- T Yamada
- T Yu
- TH Steinberg
- TH Steinberg
- TL Whiteside
- TM Chused
- TP Gottwald
- U Schenk
- U Schenk
- V Dimitriadou
- V Dimitriadou
- V Kumar
- V Ramkumar
- V Vraux Le
- VB Mehta
- VS Muniz
- W Nörenberg
- W Walz
- W Wei
- WC Sun
- WG Junger
- WG Junger
- WH Loomis
- WM Hon
- X Duhant
- X Hua
- X Hua
- X Zhong
- Y Bao
- Y Chen
- Y Chen
- Y Hu
- Y Inoue
- Y Inoue
- Y Kohno
- Y Kurashima
- Y Qu
- Y Qu
- Y Qu
- Y Zhang
- YG Chen
- YJ Chen
- YX Qian
- Z Saze
- Z Yang
- Z Yang
- Z Zhang
- Z Zídek
- ZA Pfeiffer
- ZG Gao
- ZG Gao
- ZH Németh
- ZH Németh
- ZH Németh
- ZQ Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
This review article provides a historical perspective on the role of purinergic signalling in the regulation of various subsets of immune cells from early discoveries to current understanding. It is now recognised that adenosine 5'-triphosphate (ATP) and other nucleotides are released from cells following stress or injury. They can act on virtually all subsets of immune cells through a spectrum of P2X ligand-gated ion channels and G protein-coupled P2Y receptors. Furthermore, ATP is rapidly degraded into adenosine by ectonucleotidases such as CD39 and CD73, and adenosine exerts additional regulatory effects through its own receptors. The resulting effect ranges from stimulation to tolerance depending on the amount and time courses of nucleotides released, and the balance between ATP and adenosine. This review identifies the various receptors involved in the different subsets of immune cells and their effects on the function of these cells
Lawson criterion for ignition exceeded in an inertial fusion experiment
- Author
- Abu-Shawareb H
- Acree R
- Adams J
- Adams P
- Addis B
- Aden R
- Adrian P
- Afeyan BB
- Aggleton M
- Aghaian L
- Aguirre A
- Aikens D
- Akre J
- Albert F
- Albrecht M
- Albright BJ
- Albritton J
- Alcala J
- Alday C
- Alessi DA
- Alexander N
- Alfonso J
- Alfonso N
- Alger E
- Ali SJ
- Ali ZA
- Alley WE
- Amala P
- Amendt PA
- Amick P
- Ammula S
- Amorin C
- Ampleford DJ
- Anderson RW
- Anklam T
- Antipa N
- Appelbe B
- Aracne-Ruddle C
- Araya E
- Arend M
- Arnold P
- Arnold T
- Asay J
- Atherton LJ
- Atkinson D
- Atkinson R
- Auerbach JM
- Austin B
- Auyang L
- Awwal AS
- Ayers J
- Ayers S
- Ayers T
- Azevedo S
- Bachmann B
- Back CA
- Bae J
- Bailey DS
- Bailey J
- Baisden T
- Baker KL
- Baldis H
- Barber D
- Barberis M
- Barker D
- Barnes A
- Barnes CW
- Barrios MA
- Barty C
- Bass I
- Batha SH
- Baxamusa SH
- Bazan G
- Beagle JK
- Beale R
- Beck BR
- Beck JB
- Bedzyk M
- Beeler RG
- Beeler RG
- Behrendt W
- Belk L
- Bell P
- Belyaev M
- Benage JF
- Benedetti LR
- Benedict LX
- Bennett G
- Berger R
- Bernat T
- Bernstein LA
- Berry B
- Bertolini L
- Berzak Hopkins L
- Besenbruch G
- Betcher J
- Bettenhausen R
- Betti R
- Bezzerides B
- Bhandarkar SD
- Bickel R
- Biener J
- Biesiada T
- Bigelow K
- Bigelow-Granillo J
- Bigman V
- Bionta RM
- Birge NW
- Bitter M
- Black AC
- Bleile R
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- Bliss E
- Bliss E
- Blue B
- Boehly T
- Boehm K
- Boley CD
- Bonanno R
- Bond EJ
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- Bourgade J-L
- Bousquet J
- Bowers J
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- Boyd R
- Bozek A
- Bradley DK
- Bradley KS
- Bradley L
- Bradley PA
- Brannon L
- Brantley PS
- Braun D
- Braun T
- Brienza-Larsen K
- Briggs TM
- Britten J
- Brooks ED
- Browning D
- Bruhn MW
- Brunner TA
- Bruns H
- Brunton G
- Bryant B
- Buczek T
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- Burkhart S
- Burmark J
- Burnham A
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- Butlin B
- Cabeltis R
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- Cagadas B
- Caggiano J
- Cahayag R
- Caldwell SE
- Calkins S
- Callahan DA
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- Castillo A
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- Chen H
- Chen H
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- Chen L-Y
- Cheng B
- Chittenden J
- Choate C
- Chou J
- Chrien RE
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- Chung M
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- Cross D
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- Czechowicz D
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- Di Nicola J-MG
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- Dimonte G
- Dittrich TR
- Divol L
- Dixit SN
- Dixon J
- Dodd ES
- Dolan D
- Donovan A
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- Dreifuerst G
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- Zimmerman GB
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- Zuegel JD
- Zylstra AB
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 06/07/2022
- Field of study
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
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- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
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- T Amit
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
- TJ Gibson
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- U Buescher
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- U Heinz
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- U Schönbeck
- UN Das
- V Adam-Vizi
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- V Irazusta
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- VA Kostyuk
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- X Chen
- X Chen
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- X Huang
- X Huang
- X Huang
- X Li
- X Zhang
- X Zhu
- X Zhu
- XD Huang
- XJ Li
- XM Yuan
- XM Yuan
- XP Huang
- Y Almog
- Y Avramovich-Tirosh
- Y Bao
- Y Bdolah
- Y Chen
- Y Christen
- Y Curin
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- Y Deugnier
- Y Engin-Üstün
- Y Ge
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- Y Haruna
- Y Honda
- Y Hua
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- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
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- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Fungal G-protein-coupled receptors::mediators of pathogenesis and targets for disease control
- Author
- A Forche
- A Gehrke
- A Jermy
- A Lafon
- A Manglik
- A Selmecki
- A Tag
- AM Calvo
- B Liu
- BB Magee
- BL Roth
- C Boone
- C Cugini
- C Fu
- CA Johnston
- CM Grice
- CM Hull
- CM Hull
- CP Semighini
- CP Semighini
- CW Yun
- CY Xue
- CY Xue
- D Dignard
- D Turra
- D Wacker
- DA Hogan
- DE Siekhaus
- DI Tsitsigiannis
- DI Tsitsigiannis
- DJ Yun
- DP Bebber
- DP Staus
- DS Perlin
- E Leberer
- E Szewczyk
- EF Kong
- ER Ballou
- FF Severin
- GB Burow
- GD Brown
- GH Huang
- H Chen
- H Fones
- H Lu
- HG Dohlman
- HJ Cools
- HS Ma
- IE Cabrera
- IP Oswald
- IV Ene
- J Carlsson
- J Cremer
- J Garcia-Martinez
- J Heitman
- J Heitman
- J Heitman
- J Morschhauser
- J Serneels
- J Steyaert
- JA Alspaugh
- JA Fraser
- JA Seo
- JG Chen
- JH Yu
- JM Thevelein
- K Ansari
- K Claes
- K Kochman
- K Lemaire
- K Machida
- K Machida
- K Palczewski
- KH Han
- KJ Affeldt
- KJ Daniels
- KS Chung
- L Li
- L Vachova
- LA Kelley
- LE Kilpatrick
- LF Thatcher
- LH Okagaki
- M Brodhagen
- M Conrad
- M Savoldi
- M Versele
- M Wheatley
- MA Coca
- MC Fisher
- MC Lorenz
- MG Jung
- MM Maidan
- MM Maidan
- NA Brown
- NA Brown
- NA Brown
- NA Brown
- P Albuquerque
- P Albuquerque
- P Dijck Van
- P Kolb
- P Moussatche
- PA Vidi
- PE Verweij
- PJ Cullen
- R Ahmad
- R Grisshammer
- R Ramanujam
- R Velagapudi
- RA Wilson
- RB Roberto Di
- RD Kulkarni
- RJ Bennett
- RJ Ward
- RM Eglen
- RM Welton
- S Abe
- S Ghosh
- S Spikes
- SE Kidd
- SH Brown
- SH Martin
- SS Phadke
- SY Chung
- T Harashima
- T Harashima
- T McDonald
- T Miwa
- TM DeZwaan
- WF Loomis
- WL Bryden
- Y Lee
- YC Chang
- YC Chang
- YJ Kou
- YP Hsueh
- YT Tang
- YY Cao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
G-protein signalling pathways are involved in sensing the environment, enabling fungi to coordinate cell function, metabolism and development with their surroundings, thereby promoting their survival, propagation and virulence. G-protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in fungi. Despite the apparent importance of GPCR signalling to fungal biology and virulence, relatively few GPCR–G-protein interactions, and even fewer receptor-binding ligands, have been identified. Approximately 40% of current pharmaceuticals target human GPCRs, due to their cell surface location and central role in cell signalling. Fungal GPCRs do not belong to any of the mammalian receptor classes, making them druggable targets for antifungal development. This Review Article evaluates developments in our understanding of fungal GPCR-mediated signalling, while substantiating the rationale for considering these receptors as potential antifungal targets. The need for insights into the structure–function relationship of receptor–ligand interactions is highlighted, which could facilitate the development of receptor-interfering compounds that could be used in disease control
Prime Focus Spectrograph (PFS) for the Subaru telescope: Ongoing integration and future plans
- Author
- Aghazarian H
- Arnouts S
- Balard P
- Barette R
- Barkhouser RH
- Belhadi M
- Burnham JA
- Caplar N
- Carr MA
- Chabaud PY
- Chang YC
- Chen HY
- Chou CY
- Chu YH
- Cohen JG
- De Almeida RP
- De Oliveira AC
- De Oliveira LS
- Dekany RG
- Dohlen K
- Dos Santos JB
- Dos Santos LH
- Ellis RS
- Fabricius M
- Ferreira D
- Furusawa H
- Garcia-Carpio J
- Golebiowski M
- Gross J
- Gunn JE
- Hammond R
- Harding A
- Hart M
- Heckman TM
- Ho PTP
- Hope SC
- Hover DJ
- Hsu SF
- Hu YS
- Huang PJ
- Ishizuka Y
- Jamal S
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- Reiley DJ
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- Publication venue
- 'Instytut Dermatologii Radoslaw Spiewak'
- Publication date
- 01/01/2018
- Field of study
PFS (Prime Focus Spectrograph), a next generation facility instrument on the 8.2-meter Subaru Telescope, is a very wide-field, massively multiplexed, optical and near-infrared spectrograph. Exploiting the Subaru prime focus, 2394 reconfigurable fibers will be distributed over the 1.3 deg field of view. The spectrograph has been designed with 3 arms of blue, red, and near-infrared cameras to simultaneously observe spectra from 380nm to 1260nm in one exposure at a resolution of ∼ 1.6-2.7Å. An international collaboration is developing this instrument under the initiative of Kavli IPMU. The project recently started undertaking the commissioning process of a subsystem at the Subaru Telescope side, with the integration and test processes of the other subsystems ongoing in parallel. We are aiming to start engineering night-sky operations in 2019, and observations for scientific use in 2021. This article gives an overview of the instrument, current project status and future paths forward
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Development of the Canadian Physiotherapy Assessment of Clinical Performance: A New Tool to Assess Physiotherapy Students' Performance in Clinical Education
- Author
- Publication venue
- 'University of Toronto Press Inc. (UTPress)'
- Publication date
- Field of study
- …