Lobotomia pré-frontal. Resultados clínicos em hospital privado

Escola Paulista de Medicina Instituto Paulista Serviço de PsiquiatriaHospital de JuqueriSecção de Higiene Mental Escolar Serviço de Neuro-Psiquiatria do Instituto PaulistaUNIFESP, EPM, Instituto Paulista Serviço de PsiquiatriaSciEL

Résultats électroencéphalographiques dans 33 cas de tumeurs intracraniennes chirurgicalement vérififes

Escola Paulista de MedicinaUniv. de São Paulo Fac. Med.Instituto de Electrencefalografia (São Paulo)Escola Paulista de Medicina Serviço de NeurologiaUNIFESP, EPM, Serviço de NeurologiaSciEL

Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study

Objectives. Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations.Methods. SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses.Results. The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP.AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001].Conclusion. Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Psicoses tóxicas consequentes a administração de quinacrina

Lembrando os benéficos efeitos dos medicamentos à base de quinacrina (Metoquina, Atebrina) cuja descoberta veio reforçar de maneira eficiente o combate à malária, os autores salientam a possibilidade do aparecimento de complicações mentais em pequena percentagem de doentes tratados com esses medicamentos. É necessário reconhecer a possibilidade de certas pessoas serem provàvelmente sensíveis ao medicamento e que, mesmo com doses normais ou inferiores às usadas no tratamento convencional, apresentam reações mentais anômalas. A presente comunicação tem por fim apenas chamar a atenção para esta eventualidade, exemplificando-a com o relato de dois casos observados em um hospital psiquiátrico